The invention provides a wheel-set flaw detection driving device which comprises two driving parts and a driving motor. Each driving part comprises a support part, a support plate, a rotating wheel mounting base, a driving wheel and a driven wheel; each rotating wheel mounting base comprises a first bottom plate, a first flank and a second flank, wherein the first flank and the second flank each comprises a first through hole used for installing the corresponding driving wheel, a first slot hole used for installing the corresponding driven wheel and a groove used for clamping a wheel shaft, each support part is installed at the bottom of the corresponding support plate, and the driving motor is connected with a central shaft of each driving wheel. According to the wheel-set flaw detection driving device, by means of the support parts, treads of support wheel sets get away from the ground, the driving motor drives the driving wheels to rotate and drive the wheel shafts of the wheel sets to rotate, abrasion caused by contact between the treads of the wheel sets and the ground is reduced, stable rotation of the wheel sets can be guaranteed, and therefore the flaw detection device can conduct accurate flaw detection on the wheel sets.