The invention provides a solid high-temperature aerobic fermentation reaction system and method. The system comprises a solid high-temperature aerobic fermentation system, a furnace system, an odor and flue gas treatment system, a detection system and a control system; the solid high-temperature aerobic fermentation system comprises 1-X solid high-temperature aerobic fermentation reactors, and each solid high-temperature aerobic fermentation reactor comprises an oblique horizontally drum, a feed side, a closed labyrinth sealing device arranged on a discharge side, a power supporting wheel set, a stirring anti-sticking device and an integrated base, wherein the horizontal drum is sleeved with a water sleeve, the stirring anti-sticking device is located in the horizontal drum, and the horizontal drum is arranged on the power supporting wheel set; the furnace system comprises a hot water furnace, a circulating water pump, a three-way electric adjusting valve and an electromagnetic valve, and effluent of the furnace system is connected and communicated with clamping sleeves of the solid high-temperature aerobic fermentation reactors; the odor and flue gas treatment system comprises an odor heat exchange condenser, a flue gas heat exchange condenser, a biological deodorizing filter tower, an induced draft fan and an electromagenetic valve; the detection control system is set in the mode that all system sensors output detection signals to be connected with a controller, and the controller controls all the systems to work coordinately. The system conducts reductive, harmless and resourceful treatment on pollutants, is small in occupied area, high in fermentation efficiency and good in environment-friendly effect and is not influenced by environmental factors and a low-temperature condition.