The present invention relates to a cytoprotective, neuroprotective and retinal protective composition. In one embodiment of the invention, the composition comprises (i) ramipril or ramipril and (ii) folic acid. The compositions of the invention can be used, in particular, for the prevention of vision loss and even for the improvement of vision and visual field in normal individuals, as well as for the treatment of ophthalmic diseases, in particular glaucoma, diabetic retinopathy, age-related macular degeneration, hereditary retinal diseases Malnutrition, uveitis, refractive errors (myopia, presbyopia). This combination of active ingredients can also be used in the treatment of general pathologies of general diseases (cancer...).