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The Folic Acid-Ramipril Combination: A Cytoprotective, Neuroprotective and Retinoprotective Ophthalmic Composition

A technology for retinopathy and folic acid, which is applied in the field of cell protection, maintenance or improvement of visual function, neuroprotection and retinal protection composition, and can solve problems such as physiological vision loss and retinal dystrophy

Inactive Publication Date: 2017-12-12
拉乌夫·雷基克
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 4. Hereditary retinal dystrophies (including pigmentary retinopathy and Stargardt (Stargardt) macular degeneration);
[0016] 11. Physiological vision loss

Method used

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  • The Folic Acid-Ramipril Combination: A Cytoprotective, Neuroprotective and Retinoprotective Ophthalmic Composition
  • The Folic Acid-Ramipril Combination: A Cytoprotective, Neuroprotective and Retinoprotective Ophthalmic Composition
  • The Folic Acid-Ramipril Combination: A Cytoprotective, Neuroprotective and Retinoprotective Ophthalmic Composition

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0212] Point 1. A method of maintaining or improving the vision and / or field of vision of a patient in need of such treatment. The method comprises the steps of: administering a pharmaceutical composition comprising ramipril (an angiotensin converting enzyme inhibitor) and folic acid. This medicine can maintain or improve vision and field of vision.

[0213] Point 2. The method according to point 1, wherein the drug is a cytoprotective, neuroprotective and / or retinal protective agent.

[0214] Point 2a. Method according to point 1, wherein said drug is combined with one or several compounds selected from: L-arginine, H4b, vitamin B6, vitamin B12, vitamin C, omega-3 fatty acids , magnesium, potassium, glucose, NSAIDs, steroidal anti-inflammatory agents, and amino acids such as leucine (especially acetyl-leucine), beta-blockers, epinephrine, norepinephrine hormones, alpha-adrenoceptor agonists, and anti-VEGF agents.

[0215] Point 3. The method according to point 1, wherein t...

Embodiment

[0231] Embodiment: clinical observation

[0232] In the clinical case disclosed below, the active ingredients, in particular ramipril and folic acid, were administered continuously (i.e. at least once a day), 1.25 mg of ramipril was administered orally per day and topically 5mg folic acid.

[0233] The clinical observations disclosed below are of course provided by way of example only and do not limit the invention in any way. Of note, the same observations were made in "normal" patients (particularly elderly patients over 60 years of age) without any ophthalmic pathology who were administered the drug; these patients noted their visual acuity Improvement, in particular, that older people regain the average sensitivity they had when they were very young.

[0234] Glaucoma and glaucomatous neuropathy: Combination administration of ramipril and folic acid, either in oral or topical form, caused improvement in visual function (vision or field of view) and reduction in intraocu...

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Abstract

The present invention relates to a cytoprotective, neuroprotective and retinal protective composition. In one embodiment of the invention, the composition comprises (i) ramipril or ramipril and (ii) folic acid. The compositions of the invention can be used, in particular, for the prevention of vision loss and even for the improvement of vision and visual field in normal individuals, as well as for the treatment of ophthalmic diseases, in particular glaucoma, diabetic retinopathy, age-related macular degeneration, hereditary retinal diseases Malnutrition, uveitis, refractive errors (myopia, presbyopia). This combination of active ingredients can also be used in the treatment of general pathologies of general diseases (cancer...).

Description

technical field [0001] The present invention relates to a composition, in particular, a cytoprotective, neuroprotective and retinal protective composition, which is particularly suitable for maintaining or improving visual function (sight or visual field). In an embodiment of the present invention, the composition comprises (i) Ramipril or Ramipril and (ii) folic acid. Background technique [0002] The invention also relates to the use of said composition for the prophylaxis or treatment of different types of diseases or disorders, in particular cancers or ophthalmic diseases or disorders involving the chorioretinal and / or optic nerve, which lead to progressive loss of vision (vision and / or visual field ). [0003] Effects on vision have been observed, especially in glaucoma, macular degeneration, hereditary retinal diseases, myopia, presbyopia, uveitis and diabetic retinopathy. [0004] In an embodiment of the present invention, angiotensin-converting enzyme inhibitor (su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/00A61K31/198A61K31/20A61K31/375A61K31/403A61K31/505A61K31/519A61K31/70A61K31/714A61K33/06A61K33/14
CPCA61K9/0048A61K31/198A61K31/20A61K31/375A61K31/403A61K31/4415A61K31/505A61K31/519A61K31/70A61K31/7004A61K31/714A61K33/06A61K33/14A61K45/06A61K31/405A61K31/4985A61P25/00A61P25/16A61P25/28A61P27/02A61P27/04A61P27/06A61P27/10A61P27/14A61P29/00A61P31/04A61P31/12A61P31/18A61P33/00A61P35/00A61P3/06A61P37/02A61P9/10A61P9/12A61P3/10A61K2300/00
Inventor 拉乌夫·雷基克
Owner 拉乌夫·雷基克
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