51 results about "Vascular flow" patented technology

Computer aided visualization and diagnosis by volume analysis of optical coherence tomography (OCT) angiographic data. In one embodiment, such analysis comprises acquiring an OCT dataset using a processor in conjunction with an imaging system; evaluating the dataset, with the processor, for flow information using amplitude or phase information; generating a matrix of voxel values, with the processor, representing flow occurring in vessels in the volume of tissue; performing volume rendering of these values, the volume rendering comprising deriving three dimensional position and vector information of the vessels with the processor; displaying the volume rendering information on a computer monitor; and assessing the vascularity, vascular density, and vascular flow parameters as derived from the volume rendered images.

A system and method for estimating vascular flow using CT imaging include a computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to acquire a first set of data comprising anatomical information of an imaging subject, the anatomical information comprises information of at least one vessel. The instructions further cause the computer to process the anatomical information to generate an image volume comprising the at least one vessel, generate hemodynamic information based on the image volume, and acquire a second set of data of the imaging subject. The computer is also caused to generate an image comprising the hemodynamic information in combination with a visualization based on the second set of data.

Real time, high-speed image stabilization with a retinal tracking scanning laser ophthalmoscope (TSLO) enables new approaches to established diagnostics. Large frequency range (DC to 19 kHz), wide-field (40-deg) stabilized Doppler flowmetry imaging is described for human subjects. The fundus imaging method is a quasi-confocal line-scanning laser ophthalmoscope (LSLO). The retinal tracking system uses a confocal reflectometer with a closed loop optical servo system to lock onto features in the ocular fundus and automatically re-lock after blinks. By performing a slow scan with the laser line imager, frequency-resolved retinal perfusion and vascular flow images can be obtained free of eye motion artifacts.

An automatic portable ambulant miniaturized system for applying pneumatic pressure to a body limb including a portable ambulant hand-held fluid source unit, a conduit for delivering fluid generated by the unit, and a pressure sleeve coupled to the conduit and adapted to envelop a body limb. The pressure sleeve contains individually inflatable cells, each cell being subdivided into longitudinally extending confluent intra-cell compartments along the axis of the body limb. The intra-cell compartments are inflated and deflated essentially simultaneously by the portable fluid source unit. To increase the pick venous velocity generated by any kind of external compressive force on a limb with any kind of tempo-spatial regime, the venous phasic flow is monitored to determine so that the venous flow generated by the external compressive force can be synchronized with the in-phasic natural venous flow.

An automatic portable ambulant miniaturized system for applying pneumatic pressure to a body limb including a portable ambulant hand-held fluid source unit, a conduit for delivering fluid generated by the unit, and a pressure sleeve coupled to the conduit and adapted to envelop a body limb. The pressure sleeve contains individually inflatable cells, each cell being subdivided into longitudinally extending confluent intra-cell compartments along the axis of the body limb. The intra-cell compartments are inflated and deflated essentially simultaneously by the portable fluid source unit. To increase the peak venous velocity generated by any kind of external compressive force on a limb with any kind of tempo-spatial regime, the venous phasic flow is monitored to determine so that the venous flow generated by the external compressive force can be synchronized with the in-phasic natural venous flow.

Real time, high-speed image stabilization with a retinal tracking scanning laser ophthalmoscope (TSLO) enables new approaches to established diagnostics. Large frequency range (DC to 19 kHz), wide-field (40-deg) stabilized Doppler flowmetry imaging is described for human subjects. The fundus imaging method is a quasi-confocal line-scanning laser ophthalmoscope (LSLO). The retinal tracking system uses a confocal reflectometer with a closed loop optical servo system to lock onto features in the ocular fundus and automatically re-lock after blinks. By performing a slow scan with the laser line imager, frequency-resolved retinal perfusion and vascular flow images can be obtained free of eye motion artifacts.

Systems and methods for overcoming or preventing vascular flow restrictions which involve: (1) providing at least one structural element within or about a vessel having a vascular flow restriction; and (2) equipping the structural element with bio-lining such that it restores blood flow and minimizes, if not eliminates, the interface between blood and non-biological materials to thereby prevent stenosis and / or restenosis.

Computer aided visualization and diagnosis by volume analysis of optical coherence tomography (OCT) angiographic data. In one embodiment, such analysis comprises acquiring an OCT dataset using a processor in conjunction with an imaging system; evaluating the dataset, with the processor, for flow information using amplitude or phase information; generating a matrix of voxel values, with the processor, representing flow occurring in vessels in the volume of tissue; performing volume rendering of these values, the volume rendering comprising deriving three dimensional position and vector information of the vessels with the processor; displaying the volume rendering information on a computer monitor; and assessing the vascularity, vascular density, and vascular flow parameters as derived from the volume rendered images.

Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration of PEM, leading to widespread shutdown of vascular flow, hemorrhage, and necrosis. PEM constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. Such properties induce selective NME of tumors after extravasation, and will likely enhance the effect of VEGFR TKIs and / or mTOR inhibitors.

The present invention relates to a system for measuring a micro-vascular flow distribution of a tissue portion of a mammal comprising means (101) for measuring a first indicator (MTT) for the blood flow through a capillary bed, means (102) for measuring a second indicator (CTTH) of heterogeneity of the blood flow in said capillary bed, and a first processor (110) arranged for using the first and the second indicator to estimate an extraction capacity (EC) of a substance from the blood in said capillary bed.

Disclosed is a filter assembly, comprising: a radially expandable vascular flow-increasing device, and a filter including an expandable proximal opening having an operative connection with the radially expandable vascular flow-increasing device, the proximal opening configured to expand in conjunction with expansion of the device, such that when the opening is in an expanded configuration, the filter is configured to filter debris from a fluid stream in which the filter is disposed.

A method (100) of computing and displaying flow information of vascular blood flow patterns, especially in the form of quantitative data plots.

Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration of PEM as a result of the nitric oxide sequestration by PEM. Nitric oxide sequestration may cause a reduction in available extracellular nitric oxide in the tumor endothelium, which may prompt a widespread shutdown of vascular flow, hemorrhage, and necrosis. In particular, shutdown of vascular flow may trigger changes in nitric oxide production as well as trigger an acute inflammatory response, which may create reactive nitrogen species that are particularly destructive to the microvasculature. PEM constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. Such properties induce selective NME of tumors after extravasation, and will likely enhance the effect of VEGFR TKIs and / or mTOR inhibitors.

Drainage of body fluid from a first area of the body to a target area of the body can be accomplished by interconnecting an artificial non-blood fluid conduit with the venous and / or lymphatic system of the body. For example, an artificial non-blood fluid conduit can be inserted into the eye to fluidly interconnect the anterior chamber with a venous structure, such as an anterior ciliary vein, or lymphatic in a target location of the eye. The outflow end of the conduit can be positioned adjacent to and / or cannulated within the venous structure or lymphatic. Further, the conduit can optionally have an angiogenic material for stimulating growth of new blood vessels in the target location to fluidly interconnect the venous structure or lymphatic with the anterior chamber using the non-blood fluid conduit.

A method (100) of computing and displaying flow information of vascular blood flow patterns, especially in the form of quantitative data plots.

A non-invasive apparatus for detecting turbulent flow in a cerebrovascular system of a patient without use of software, includes a planar, circular head adapted to be placed against an eye socket of the patient. A microphone in the head detects an acoustic signal from the cerebrovascular system and converts the acoustic signal to an electrical signal. A filter passes only a portion of the electrical signal having a frequency in a range between 350 Hz and 1,800 Hz as a filtered electrical signal, so as to eliminate extraneous signals due to other than vascular flow. A headset has at least one ear piece with a speaker therein for converting the filtered electrical signal to an audio signal in order to detect the turbulent flow in the cerebrovascular system of the patient.

Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration of PEM, leading to widespread shutdown of vascular flow, hemorrhage, and necrosis. PEM constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. Such properties induce selective NME of tumors after extravasation, and will likely enhance the effect of VEGFR TKIs and / or mTOR inhibitors.

Computer aided visualization and diagnosis by volume analysis of optical coherence tomography (OCT) angiographic data. In one embodiment, such analysis comprises acquiring an OCT dataset using a processor in conjunction with an imaging system; evaluating the dataset, with the processor, for flow information using amplitude or phase information; generating a matrix of voxel values, with the processor, representing flow occurring in vessels in the volume of tissue; performing volume rendering of these values, the volume rendering comprising deriving three dimensional position and vector information of the vessels with the processor; displaying the volume rendering information on a computer monitor; and assessing the vascularity, vascular density, and vascular flow parameters as derived from the volume rendered images.

An ultrasound-detectable marker, ultrasound system, and methods for monitoring vascular flow and patency are disclosed. The ultrasound-detectable marker comprises one or more resorbable polymers, one or more non-resorbable polymers, one or more non-polymeric materials, or any combinations thereof. The ultrasound-detectable marker is adapted for placement underneath, adjacent to, or above one or more vessels at a postoperative site, such as a vascular anastomosis site. Further, the ultrasound imaging system includes certain user guiding software and / or health analysis software for use with the ultrasound-detectable marker.

A method and system for creating shear stress and endothelial mechanotransduction through neuromuscular stimulation of the muscle pump. Chronic application a minimum of 30 days triggers the autocrine and paracrine processes which elevates production of vasoactive substances including nitric oxide, prostacyclin, superoxide dismutase, thrombomodulin, glutathion, Krupple-like factor 2 and many others. Chronic application also promotes angiogenesis and development of collateral circulation. This is a cost-effective, non-invasive, drug-free therapy to treat vascular dysfunction and ameliorate or reverse its effects on cardiovascular health.

The present invention relates to the medical use of nitrites, such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, compositions, or prodrugs thereof, in the treatment of conditions that benefit from increased cerebral vascular flow. The pharmaceutical compositions used in these methods, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−).

An abdominal aortic stent includes a first sub-stent and a second sub-stent, each having a front end and the circumference of the front end of each sub-stent is half of the circumference of the abdominal aorta, and when the circumference is gradually reduced to a rear end of each sub-stent, it has entered one side of the bilateral femoral arteries, wherein the rear ends of the sub-stents with full circumference of the cross-sectional area of the femoral artery are included therein; the first and second sub-stents are coated with external removable membrane to compress the sub-stents to generate smaller circumferences, and when the membrane has been removed, the sub-stents are fully extended to reconstruct the vascular flow path.

Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration of PEM as a result of the nitric oxide sequestration by PEM. Nitric oxide sequestration may cause a reduction in available extracellular nitric oxide in the tumor endothelium, which may prompt a widespread shutdown of vascular flow, hemorrhage, and necrosis. In particular, shutdown of vascular flow may trigger changes in nitric oxide production as well as trigger an acute inflammatory response, which may create reactive nitrogen species that are particularly destructive to the microvasculature. PEM constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. Such properties induce selective NME of tumors after extravasation, and will likely enhance the effect of VEGFR TKIs and / or mTOR inhibitors.

A blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair of blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Flow measurement device which determines at least one blood flow parameter reflecting an average flow in relation to the blood treatment unit during a well-defined period of operation of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter is determined based on a difference between (i) a first amount of fresh blood treatment fluid received into the blood treatment unit, and (ii) a second amount of used blood treatment fluid emitted from the blood treatment unit during another well-defined period.

Apparatus and methods of use are provided for complex flow imaging and analysis that is non-invasive, accurate, and time-resolved. It is particularly useful in imaging of vascular flow with spatiotemporal fluctuations. This apparatus is an ultrasound-based framework called vector projectile imaging (VPI) that can dynamically render complex flow patterns over an imaging view at millisecond time resolution. The VPI apparatus and methods comprise: (i) high-frame-rate broad-view data acquisition (based on steered plane wave firings); (ii) flow vector estimation derived from multi-angle Doppler analysis (coupled with data regularization and least-squares fitting); and (iii) dynamic visualization of color-encoded vector projectiles (with flow speckles displayed as adjunct).

The invention discloses a hypertension blood circulation simulation device which comprises a liquid storage tank, a constant pressure tank, a flow generator, a pre-pressing device, a flow sensor, a pressure sensor, a plurality of throttle valves and a simulation blood vessel, the flow sensor comprises a front flow sensor and a rear flow sensor, and the liquid storage tank comprises a one-way waterpump and working liquid; the liquid storage tank is sequentially connected with a constant-pressure tank, a flow generator, a pre-pressing device, a front flow sensor, a pressure sensor, a pluralityof throttle valves and a rear flow sensor through simulated blood vessels. The pre-pressing device is used for applying pressure to the interior of the simulated blood vessel in a hydraulic pressure increasing mode. The pressure drop generated when the working fluid flows is calculated according to the pre-pressing device and the pressure sensor; the device can be used for further research after the flow sensors are arranged in front of and behind the device, a speed relation is obtained through analysis of the front flow sensor and the rear flow sensor, fluid pressure is adjusted through thepre-pressing device and the throttle valve, fluid speed is adjusted through the flow generator, and relevant parameters of hypertension patients are consistent.

The present invention discloses devices that can be delivered into a vascular system to divert flow. According to some embodiments, devices are provided for treating aneurysms by diverting flow. An expandable device can comprise, for example, a plurality of connector sections and a plurality of bridge sections. Each of the connector sections may extend circumferentially about the expandable deviceand include a plurality of connector struts. Each of the plurality of bridge sections may be attached to and extend between two of the connector sections and comprise a plurality of parallel, non-branching, helical bridge members.

A method and system for creating shear stress and endothelial mechanotransduction through neuromuscular stimulation of the muscle pump. Chronic application a minimum of 30 days triggers the autocrine and paracrine processes which elevates production of vasoactive substances including nitric oxide, prostacyclin, superoxide dismutase, thrombomodulin, glutathion, Krupple-like factor 2 and many others. Chronic application also promotes angiogenesis and development of collateral circulation. This is a cost-effective, non-invasive, drug-free therapy to treat vascular dysfunction and ameliorate or reverse its effects on cardiovascular health.

The invention discloses a pair of high-heeled shoes having a weight-losing function. One high-heeled shoe comprises a high-heeled shoe body, on which a vamp is arranged. The bottom end at the front part of the high-heeled shoe body is provided with a water-proof platform. The bottom end at the back part of the high-heeled shoe body is provided with a heel. One end, away from the high-heeled shoe body, of the heel is provided with a fourth groove, in which an anti-skidding block is arranged. The outer side wall of the fourth groove is provided with a fixing device. The anti-skidding block is fixed into the fourth groove via the fixing device. One end, close to the high-heeled shoe body, of the heel is provided with a first groove. The first groove is provided with a first buffer block via a first spring. The first spring is fixed into the bottom of the first groove. The pair of high-heeled shoes having the weight-losing function has following beneficial effects: acupoints of feet of a human body, highly-efficient fat-burning magnetic waves and near infrared rays are utilized for improving micro-vascular flow such that the pair of functional high-heeled shoes is designed; human channels area adjusted via a physical method in order to balance internal secretion and fat metabolism; and the weight-losing purpose is fulfilled.