The invention discloses a hypertension blood circulation simulation device which comprises a liquid storage tank, a constant pressure tank, a flow generator, a pre-pressing device, a flow sensor, a pressure sensor, a plurality of throttle valves and a simulation blood vessel, the flow sensor comprises a front flow sensor and a rear flow sensor, and the liquid storage tank comprises a one-way waterpump and working liquid; the liquid storage tank is sequentially connected with a constant-pressure tank, a flow generator, a pre-pressing device, a front flow sensor, a pressure sensor, a pluralityof throttle valves and a rear flow sensor through simulated blood vessels. The pre-pressing device is used for applying pressure to the interior of the simulated blood vessel in a hydraulic pressure increasing mode. The pressure drop generated when the working fluid flows is calculated according to the pre-pressing device and the pressure sensor; the device can be used for further research after the flow sensors are arranged in front of and behind the device, a speed relation is obtained through analysis of the front flow sensor and the rear flow sensor, fluid pressure is adjusted through thepre-pressing device and the throttle valve, fluid speed is adjusted through the flow generator, and relevant parameters of hypertension patients are consistent.