An imaging and display
system for guiding medical interventions includes a wearable display, such as a goggle display, for viewing by a user. The display presents a composite, or combined image that includes pre-operative surgical navigation images, intraoperative images, and in-vivo
microscopy images or
sensing data. The pre-operative images are acquired from scanners, such as MRI and
CT scanners, while the intra-operative images are acquired in real-time from a camera
system carried by the goggle display for imaging the patient being treated so as to acquire intraoperative images, such as
fluorescence images. A probe, such as a
microscopy probe or a sensing probe, is used to acquire in-vivo imaging /
sensing data from the patient. Additionally, the intra-operative and in-vivo images are acquired using tracking and registration techniques to align them with the pre-operative image and the patient to form a composite image for display by the goggle display.