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33 results about "Targeted disruption" patented technology

Targeted disruption of t cell and/or HLA receptors

Disclosed herein are methods and compositions for inactivating TCR and / or HLA genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domainin conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and / orcells comprising nucleases are also provided.
Owner:SANGAMO BIOSCIENCES INC
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