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33 results about "Targeted disruption" patented technology

JNK3 modulators and methods of use

The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
Owner:UNIV OF MASSACHUSETTS +1

Rounded Projectiles for Target Disruption

ActiveUS20210389107A1No reasonable riskLack of propulsionAmmunition projectilesBarrelsTrajectory of a projectileTargeted disruption
Provided are methods and related devices for disrupting an explosive device using a propellant driven disrupter (PDD) that propels a rounded projectile (RP) toward an explosive device. The RP travels along a linear trajectory and impacts the target, including a barrier portion of the explosive device. The impacting between the RP and barrier forms a composite projectile via a solid state weld between a portion of the barrier and the RP distal end, thereby minimizing or avoiding spall and fragment generation into the explosive device. The projectile traverses a penetration distance along the linear trajectory, or a defined-angle relative thereto, to disrupt the explosive device without unwanted explosive detonation.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE FEDERAL BUREAU OF INVESTIGATION DEPT OF JUSTICE

Saspase knockout animal

Knockout animals in which a gene encoding a SASPase has been deleted (hereinafter, referred to as SASPase KO animals) are provided. The SASPase KO animals deficient in expression of functional SASPase were produced by deleting a gene encoding a stratified epithelium-specific protease, SASPase, through targeted disruption. The SASPase KO animals showed a significant increase in wrinkles on the sides of the body and so on. The SASPase KO animals find utility as animal models of wrinkles.
Owner:EISIA R&D MANAGEMENT CO LTD

Targeted disruption of t cell and/or HLA receptors

Disclosed herein are methods and compositions for inactivating TCR and / or HLA genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domainin conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and / orcells comprising nucleases are also provided.
Owner:SANGAMO BIOSCIENCES INC
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