The invention relates to a method and a system for realizing multimedia interaction during a telephone call. By applying the system, when a user makes a telephone call, the multimedia interaction information customized by the other party is displayed / played on the telephones of the two parties; the multimedia interaction information supports formatted texts, sound, pictures, video, motion pictures, games, lantern slides, webpages, website links, a combination thereof, and the like; the system comprises an application server, a file server, a database server and a telephone client software; theclient software is used, the user uploads the local arbitrarily supported file and the information to the server, and the file and the information are customized into multimedia interaction information; when a telephone call is made, the telephones of the two parties for communication are used for querying and downloading the content of the multimedia interaction information of the other party respectively from the server, then the content is stored to the local call and displayed / played to the user; and the user can perform response interactive operation respectively to the multimedia interaction information, such as viewing, WEB browsing, editing, preservation, commenting, and the like.