38 results about "Glaucoma surgery" patented technology

Methods and systems are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Some embodiments described apparatus and methods useful in photoablation of tissues. In some embodiments, a photoablation apparatus is used to perforate a tissue, forming an aperture into a space behind the tissue. Gases formed during a photoablation process can be used to pressurize the space behind the tissue to enhance patency of the space. In some embodiments the tissue is the trabecular meshwork of the eye and a wall of Schlemm's canal, and the space behind the tissue is a portion of the lumen of Schlemm's canal. In some embodiments, the method is useful in the treatment of glaucoma by improving outflow from the anterior chamber of the eye into Schlemm's canal, reducing intraocular pressure.

A small gauge mechanical tissue cutter / aspirator probe useful for removing the trabecular meshwork of a human eye has a generally cylindrical outer cannula, an inner cannula that reciprocates in the outer cannula, a port located near or at the distal end of the outer cannula on a side or tip of the outer cannula, and a guide with a distal surface located on the distal end of the outer cannula. A distance between the distal surface of the guide and the port is approximately equal to the distance between the back wall of Schlemm's canal and the trabecular meshwork.

An intraocular light probe has a mask or shield affixed at its distal end thereof which forms a directed light beam for intraocular illumination of target tissues or intraocular application of therapeutic light. The mask or shield serves to more fully focus, intensify and direct the beam toward the target tissues. The mask or shield also helps direct light away from other tissues and away from the eyes of the surgeon. This lessens unwanted glare. By placing a light probe beneath a surgical instrument such as a phacoemulsifier or vitrector, laser, cutting instrument (e.g., scissors or knife), forceps or probe / manipulator, whether as part of or separate from an infusion sleeve, a mask or shield effect is created. This has the same benefits of directing the beam toward target tissues, away from other tissues and away from the eyes of the surgeon. The mask or shield is opaque or semi-opaque and made of a soft, semi-rigid or rigid material. The shield can be rigid enough to serve as the shaft of an instrument with a probe or manipulator at its distal tip. It may also be reflective on the side adjacent to the fiber bundle to help direct, magnify, and intensify the beam of light. The shape of the shield can be flat, curved or circular with an opening along one side. The mask / shield can be removed from the fiberoptic light for sterilization. The device of the invention is preferably introduced into the eye via the primary or side-port incision to provide intraocular cross-lighting of tissues during surgical procedures such as cataract surgery, corneal surgery, vitrectomy, intraocular lens implantation, refractive surgery, glaucoma surgery and vitreo / retinal surgery.

Methods and systems are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Some embodiments described apparatus and methods useful in photoablation of tissues. In some embodiments, a photoablation apparatus is used to perforate a tissue, forming an aperture into a space behind the tissue. Gases formed during a photoablation process can be used to pressurize the space behind the tissue to enhance patency of the space. In some embodiments the tissue is the trabecular meshwork of the eye and a wall of Schlemm's canal, and the space behind the tissue is a portion of the lumen of Schlemm's canal. In some embodiments, the method is useful in the treatment of glaucoma by improving outflow from the anterior chamber of the eye into Schlemm's canal, reducing intraocular pressure.

A small gauge pulsed electric field / aspirator probe. The probe has a generally cylindrical cannula with a generally smooth distal end. A port is located near a distal end of the cannula on a side of the cannula. A pair of electrodes is located at the port. An electric pulse generator is coupled to the pair of electrodes. A distance between the distal end of the cannula and the port is approximately equal to the distance between a back wall of Schlemm's canal and a trabecular meshwork in a human eye. The electric pulse generator applies a pulsed electric field to the pair of electrodes sufficient to dissociate protein bonds that hold the trabecular meshwork together.

An ablation probe for use in glaucoma surgery has a shaft, a heating element, and a pair of electrical connectors located on a distal end of the shaft. The pair of electrical connectors holds the heating element to the shaft. The heating element is sized and shaped to ablate a trabecular meshwork in a human eye. The ablation probe is advanced through a corneal incision until the heating element contacts the trabecular meshwork. An electrical current is passed through the heating element to ablate the trabecular meshwork.

A small gauge mechanical tissue cutter / aspirator probe useful for removing the trabecular meshwork of a human eye has a generally cylindrical outer cannula, an inner cannula that reciprocates in the outer cannula, a port located near or at the distal end of the outer cannula on a side or tip of the outer cannula, and a guide with a distal surface located on the distal end of the outer cannula. A distance between the distal surface of the guide and the port is approximately equal to the distance between the back wall of Schlemm's canal and the trabecular meshwork.

Methods and apparatus for measurement of IOP following glaucoma surgery comprise an implant device having a pressure sensitive capacitor and coil sized for placement along the tissue drainage path, to monitor the success of the surgery and measure IOP directly. The implantable sensor device may comprise a MEMS based capacitive pressure sensor and coil. A complaint material is disposed over the pressure sensitive capacitor and coil to conform with tissue to further decrease invasiveness and such that the implant can measure pressure from at least a first side and a second side when positioned along the drainage path. The implant can work well with trabeculectomies and trabeculotomies, and can be positioned on the sclera at a location corresponding to the bleb, such that the effectiveness of the surgery and medication can be determined postoperatively to detect pressure changes and elevations.

A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.

The invention discloses a composite biological matrix for glaucoma surgery and a preparation method thereof. The composite biological matrix has a double-layer composite structure formed by aging and freeze-drying a compact base material layer and a loose layer coated on the compact base material layer, wherein the compact base material layer is a cross-linked denuded amniotic membrane or animal tissue membrane, and the loose layer is a porous membrane prepared from a biological macromolecular material. The composite biological matrix is prepared by multiple times of cross-linking modification, so that the retention time of the composite biological matrix in vivo is significantly prolonged, the effect of stably preventing scarring for a long term is achieved, and the long-term treatment effect after filtering surgery can be effectively improved.

The invention relates to a device for use in glaucoma surgery intended for implantation in the eye. The device comprises a flat head region (8), a probe (6) which adjoins the head region (8), and a relief channel (7) which extends through the head region (8) and the probe (6) and is open at both sides. The design and dimensions of the head region (8) and of the probe (6) are such that the probe (6) can be inserted by its free end through the sclera (4) into the posterior chamber (10) of the eye in order to reduce an excessive intraocular pressure when the conjunctiva (3) is open, and such that, in the inserted position, the lower side of the head region (8) comes into abutment with the sclera (4), and the upper side of the head region (8) can be covered by closing the conjunctiva (3) such that drainage can be performed from the posterior chamber (10) into a gap (11) between the conjunctiva (3) and the sclera (4).

Provided are manufacturing of a glaucoma internal drainage replacement bionic support and an application method thereof. Through proper placing and fixation, aqueous fluid smoothly flows into a Schlemm tube through a pipe orifice supported by the bionic support, through filling of aqueous fluid, the collapse Schlemm tube is expanded again, and the aqueous fluid is drained to a collecting tube and an aqueous vein, to achieve an objective of reducing intraocular tension and treating glaucoma. A new glaucoma internal drainage replacement bionic support implantation greatly reduces operation cost and reduces operation cost for a patient while maintaining advantages of a nonpenetrating glaucoma surgery. Combined with a trabeculectomy, adaptation diseases of the glaucoma internal drainage replacement bionic support are expanded, and new thinking and suggestion are provided for treatment of glaucoma.

Methods and devices for the application of beta radiation treatment following trabeculectomy for helping to prevent post-trabeculectomy wound reversion. The devices may feature a handle and a beta radiation source. The beta radiation source may include strontium-90, yttrium-90, potassium-32, or any other appropriate radiation source or combination thereof. The device may be used to expose a trabeculectomy wound to the radiation source following the surgical procedure. In some embodiments, a drug such as 5-fluorouracil or mitomycin c is used in combination.

Eye diseases such as glaucoma can be treated using a composition containing cross-linked hyaluronic acid or a cross-linked salt of hyaluronic acid such as sodium hyalurate. The composition can be a monophasic gel. The composition can include a cross-linking agent such as 1,4-butanediol diglycidylether. The composition can contains about 2.25% (w / w) of the salt of hyaluronic acid. The composition can have a cross-linking rate of about 0.5 to 50%.

An ophthalmic irrigating solution containing hyaluronidase and an antioxidant is provided. The solution prevents a post-operative intraocular pressure rise when used during an ophthalmic surgical procedure, and also protects corneal endothelial cells. A method for preventing post-operative intraocular pressure increases in an eye during ophthalmic surgery involves irrigating an anterior chamber of the eye with an ophthalmic-solution containing hyaluronidase and an antioxidant. Kits containing hyaluronidase and base medium solutions are also provided. The kits are designed such that the hyaluronidase and base medium solution are combined and administered together to an eye of a patient during or following an ophthalmic surgical procedure, such as cataract surgery, intraocular lens surgery, corneal transplant surgery, or glaucoma surgery. Administration of the components of the kit prevents an increase in post-operative intraocular pressure and also protects corneal endothelial cells.

The invention relates to a tool to be implanted during glaucoma filtration surgery. The tool can bear and slowly release, in trace quantity, various anti-postoperative-scarring drugs and allows drugsto be supplementarily injected after complete drug consumption; the tool can also automatically promote and maintain the formation of functional filtering blebs for a patient through physical action.The tool mainly comprises three parts: shell 1, drug slow-release bag 2 and drug 3. The tool also has a simplified version, comprising an integration of shell 1 and drug slow-release bag 2. The shellis structurally simplified to slight degree, with size, shape and other parameters and mounting and application methods basically unchanged. The tool (or its simplified version) has the advantages that the aqueous humor filtering function for glaucoma filtration surgery lasts longer through medication action, physical action and other means, long-term effectiveness of the glaucoma filtration surgery is significantly improved, surgical recurrence rate is reduced, and the tool is particularly suitable for surgical treatment of various types of 'refractory' glaucoma.

The invention provides application of a collagen implant in preparing a glaucoma surgery auxiliary recovery substance, and belongs to the field of biomedical materials. The collagen is a cowhide purified collagen, and the recovery substance is a sponge-shaped collagen-chitosan matrix with a three-dimensional pore structure and the pore size distribution of 150-450 microns and serves as a surgery auxiliary recovery substance for glaucoma trabeculectomy. The recovery substance can promote the penetration of cells or aqueous humor or the discrete proliferation in the cells or aqueous humor to maintain low intraocular pressure and reduce the expression quantities of basic fibroblast growth factors, transforming growth factors and fibrous connective tissue growth factors to reduce the scarringdegree of a filtering tract; a preparation method of the recovery substance has the advantages that glutaraldehyde is not adopted as a cross-linking agent, the number of exposed amino groups in the chitosan structure can be reduced, the problem that the anti-scarring effect is not obvious due to the adhesion of excessive amino groups and the tissue is solved, the protective hydration function of chitosan chains is destroyed, pore channels in the matrix are smaller and compact, and the water absorption performance is improved.

The invention discloses a group of device for glaucoma operation, and provides a postoperative sclera flap adhesion preventive device for anti-glaucoma operation. The postoperative sclera flap adhesion preventive device comprises an abiological material, a graft and an accessory. The graft is cast in the abiological material and comprises a magnetic substance support component, and the accessory comprises an electromagnetic coil with adjustable current intensity and rhythm. The postoperative sclera flap adhesion preventive device has the advantages that glaucomatous postoperative sclera flap adhesion can be reduced by the aid of the postoperative sclera flap adhesion preventive device, an eyeball massaging effect can be realized after the operation, the intraocular pressure of a patient can be regulated after the operation, a long-term effect of the operation can be improved, and a failure rate of trabeculectomy can be reduced.

A valve device for use in glaucoma surgery comprises at least one aqueous humor feeding duct (2) having a first end (2a) designed to fit into the anterior chamber of the eyeball, a balancing chamber (3) communicating with a second end (2b) of the feeding duct (2) and having an inner volume ranging from 2 mm3 to 6 mm3, and designed to be introduced into a surgical groove in the sclera, a retainer member (6) placed within the feeding duct (2) to allow fluid transfer from the first end (2a) toward the second end (2b) of the feeding duct (2) and to inhibit fluid transfer in the opposite direction. A plurality of aqueous humor outflow ducts (5) extend from the balancing chamber (3) to allow outflow of aqueous humor from the balancing chamber (3) to an outside space.

The invention discloses the use of a collagen implant in the preparation of glaucoma surgery auxiliary restoration, wherein the collagen implant is composed of dried and dehydrated bovine hide purified collagen, and has 20- 200 microns of three-dimensional voids.

A method for integrated eye surgery can include determining a cataract-target region in a lens of the eye; applying cataract-laser pulses to photodisrupt a portion of the determined cataract-target region; determining a glaucoma-target region or an astigmatism-target region in a peripheral region of the eye; and applying surgical laser pulses to create one or more incisions in the glaucoma- or astigmatism-target region by photodisruption; wherein the steps of the method are performed within an integrated surgical procedure. The laser pulses can be applied before making an incision on a cornea of the eye. The integrated surgical procedure may involve using the same pulsed laser source for three functions: for photodisrupting the target region, for making an incision on the capsule of the lens and for making an incision on the cornea of the eye.

The invention belongs to the field of medical equipment, and specifically provides a portable eye intensifier, including a pressurized arc with a pressure rod, a pressure rod sleeve, a spring, a fine-tuning bolt and a shell; the upper and lower ends of the shell are respectively provided with first gaps and the second notch, and the second notch is provided with a flange extending into the shell, and the flange is provided with threads; the pressure rod is sleeved in the shell to form a cavity with the shell, and A baffle is provided between the cavity and the first notch; the spring is arranged in the cavity, and the pressing rod passes through the first notch to connect the press arc with the pressing rod sleeve; The fine-tuning bolt is arranged under the spring and is threadedly connected with the folded edge. The present invention can replace springs, adjust fine-tuning bolts as required, select different pressurized pressures, and can quantitatively control the pressure; at the same time, it has the characteristics of simple structure, convenient carrying and adjustment, easy control, stable work, suitable for assembly line production, etc., especially suitable for Massage of the filtering bleb after glaucoma surgery.

The invention discloses a depth knife is used for a glaucoma surgery and comprises a knife handle and a knife body; the knife handle comprises a cylindrical main body part and a conical holding part connected to one end of the main body part, the main body part and the holding part are integrally formed, a notch is formed in one end, away from the holding part, of the main body part, the notch is used for preventing rolling of an incision cutter or jamming of packaging during surgery, the cutter body comprises a connecting part and a cutting edge part, the connecting part is connected with one end, away from the main body part, of the holding part, a center line of the connecting part coincides with a center line of the cutter handle, a cutting edge part comprises a cutting edge main body and a cutting edge, a lower end of the cutting edge main body is provided with a flat face with a reference positioning function, the cutting edge extends downwards from a front end of the cutting edge main body and is used for cutting conjunctiva, and a height difference between a cutting part of the cutting edge and the flat face is 0.3 mm-0.5mm. The depth cutter has a fixed and accurate cutting depth.

The invention discloses a chamber angle observation mirror. The chamber angle observation mirror comprises a mirror frame and a lens installed on the mirror frame, wherein the mirror frame comprises ahandle, a floating support and a stabilization piece, and the handle, the floating support and the stabilization piece form the suspension mirror frame, so that the lens stably floats and is installed above the eyeball; the handle is used for installing the installation end of the lens and is hinged to the floating support which can rotate within a certain range, and one end of the floating support is hinged to the lens which can rotate within the certain range; the stabilization piece is in direct contact with the eyeball and limits the relative position between the lens and the eyeball; theend, facing the eyeball, of the lens is a concave surface, and the end, away from the eyeball, is a convex surface with a non-spherical surface; the optical axis of the concave surface and the optical axis of the convex surface are not coaxial, that is, the lens is of an off-axis lens optical framework. The observation mirror is very convenient to use in glaucoma surgeries, and the smooth and quick surgeries are guaranteed.

A medical device for glaucoma surgery includes a tubular body provided with a through cavity extending from a proximal end to a distal end. The tubular body has a first proximal positioning means at the proximal end, and a second distal positioning means at the distal end. The tubular body has at least one proximal filtration hole, located on the side of the proximal end, and at least one distal filtration hole, located on the side of the distal end, the proximal and distal holes being fluidically connected to each other by the through cavity. The proximal and distal filtration holes are at least partially or completely occluded by a membrane made of resorbable material at least partially removable by selective action, so as to allow selective variation of the amount of aqueous humor flow removable via the through cavity.

This application disclosed a composition and method that use Nidanbu to improve the success rate of glaucoma filtration surgery.Nidyb can be used alone or in the eye or implanted eye preparations or combined with anti -metabolic drugs.