31 results about "Elevated ph" patented technology

A stannous methanesulfonate solution for tin electroplating applications and a method of forming the same are disclosed. The solution has an elevated pH. The solution also has a sufficient tin concentration for electroplating applications.

A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active form, with the native structure, are shown in Table I. The method has two key steps to unfold and then refold the proteins expressed in the inclusion bodies. The first step is to raise the pH of the protein solution in the presence of denaturing agents to pH greater than 9, preferably 10. The protein solution may be maintained at the elevated pH for a period of up to about 24 hours, or the pH immediately decreased slowly, in increments of about 0.2 pH units / 24 hours, until the solution reaches a pH of about 8.0, or both steps used. In the preferred embodiment, purified inclusion bodies are dissolved in 8 M urea, 0.1 M Tris, 1 mM glycine, 1 mM EDTA, 10 mM beta-mercaptoethanol, 10 mM dithiothreitol (DTT), 1 mM reduced glutathione (GSH), 0.1 mM oxidized glutathione (GSSG), pH 10. The absorbance at 280 nm (OD280) of the protein solution is 5.0. This solution is rapidly diluted into 20 volumes of 20 mM Tris base. The resulting solution is adjusted to pH 9.0 with 1 M HCl and is kept at 4° C. for 24 hr. The pH is adjusted to pH 8.8 and the solution is kept at 4° C. for another 24 hrs. This process is repeated until the pH is adjusted to 8.0. After 24 hr at pH 8.0, the refolded proteins can be concentrated by ultrafiltration and applied to a gel filtration column for purification.

An economical method for recovering phosphate or phosphate and nitrogen from liquid streams. A liquid containing phosphate is introduced into a culture of autotrophic microorganisms in the presence of natural or artificial light, thereby producing a liquid effluent with elevated pH and reduced alkalinity. The alkalinity is reduced through the consumption of bicarbonate / carbonate by the autotrophic microorganisms. The effluent is then chemically treated with low-cost chemicals to provide Ca++ or Mg++ ions necessary to form a phosphate precipitate such as calcium phosphate or magnesium-ammonium-phosphate (MAP). The autotrophic microorganisms can be cultivated in ponds, lagoons, or photobioreactors. The pH of the culture is adjustable within a preferred range of 7.5 to 10.5 by adjusting the photobioreactor operation. The process includes an economical flotation separator for solid, liquid, gas separation and a means of concentrating ammonia nitrogen that may also be removed during the process of phosphate reclamation.

There is provided a process for recovery of lignin from a black liquor that contains either soluble or dispersed lignin, generating a “liquid lignin” at high yield. Soluble lignin at elevated pH is precipitated by reducing the pH of the black liquor stream by countercurrent reaction with carbon dioxide, at elevated temperature and pressure, creating two bulk fluid phases: a heavy lignin-rich phase and a light lignin-depleted phase. The heavy lignin-rich phase is separated and washed countercurrently with a strong acid to displace metal cations from the lignin, creating a low-salt lignin, which is then formed into a low-dust high-bulk-density lignin fuel pellet. If needed, especially for lignin recovered from kraft papermaking black-liquor streams, an oxidation step is included to eliminate negative odor for high-value green-chemistry applications.

Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (RPE) cells of the eye of the patient. Further, this method is achieved by modulating the action of the P2X7 and / or P2Y12 receptors of the RPE cells, specifically decreasing the acidity (pHL) of the RPE lysosomes by administering selected receptor antagonists affecting the action of the P2X7 and / or P2Y12 receptors of the RPE. Methods for selecting and quantifying the effectiveness of drugs to restore pHL and determine outer segment clearance rates is also provided using a high through-put screening protocol.

Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (RPE) cells of the eye of the patient. Further, this method is achieved by modulating the action of the P2X7 and / or P2Y12 receptors of the RPE cells, specifically decreasing the acidity (pHL) of the RPE lysosomes by administering selected receptor antagonists affecting the action of the P2X7 and / or P2Y12 receptors of the RPE. Methods for selecting and quantifying the effectiveness of drugs to restore pHL and determine outer segment clearance rates is also provided using a high through-put screening protocol.

A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

A synergistic composition and method is provided for controlling odor from waste products. The composition comprises a combination of magnesium hydroxide and a sulfide-consuming compound. The method includes adding a sufficient amount of the composition to a waste stream to provide sufficient sulfide-consuming compound to effect immediate removal of sulfide. The composition incorporates a pH elevating and buffering compound, which both increases and buffers the pH. The increased pH serves to reduce both the volatile sulfide species and the volatile fatty acid (VFAs) species. The elevated pH also promotes the growth of naturally occurring bacteria which metabolize the sulfide to an innocuous form. Finally, addition of the composition drives the pH into a range where the growth of sulfide producing bacteria is inhibited. The mixture has surprisingly been found to be synergistic with respect to both control of chemical species that produce odors and corrosion of metals commonly found in sludge dewatering equipment.

Various embodiments relate to methods and systems for removing phosphorus and / or nitrogen from water. A method of removing phosphorus and nitrogen from water includes passing starting material water including nitrogen and phosphorus through an elevated pH phosphorus removal stage. The method includes passing the water through an electrolytic nitrogen removal stage. The method includes passing the water through a galvanic phosphorus removal stage. The water produced by the method has a lower phosphorus concentration and a lower nitrogen concentration than the starting material water.

Provided herein is a disclosure that blending a dicarboxylic acid with a ketonic acid, used as a preservative in a end-use formulation, such as a personal care product, can mitigate the discoloration of the end-use formulation which is caused by an elevated pH in the end-use formulation or in end-use formulations which have been exposed to elevated temperature.

A method of treating biofilm disease using a pH adjusted therapeutic rinse that comprises two parts that are separated and in amounts that upon mixing provide a single dose. The two parts together and then rinsing a patient's mouth with the single dose and expectorating.

A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.

A security element for securing value documents comprises a first polymer containing a feature substance, which is at least partially surrounded by a second polymer, wherein the first polymer is a hydrophobic, water-insoluble polymer which, at an elevated pH value and at elevated ambient temperature at a treatment duration of less than 60 minutes can be converted into a hydrophilic, water-soluble polymer. The security elements also contains a second polymer, which is a hydrophilic, water-soluble polymer, wherein the elevated pH value is greater than 12 and the elevated ambient temperature is greater than 90° C.

There is provided a process for recovery of lignin from black liquor that contains either soluble or dispersed lignin, generating a “liquid-lignin” at high yield. Lignin at elevated pH is precipitated by reducing the pH of the black liquor stream with carbon dioxide, at elevated temperature and pressure, creating two bulk fluid phases: a dense liquid-lignin phase and a light lignin-depleted phase. The dense liquid-lignin phase is separated and washed with a strong acid to displace metal cations from the lignin, creating a low-salt, randomly shaped lignin. If needed, especially for lignin recovered from kraft papermaking black-liquor streams, an oxidation step is included to eliminate negative odor for high value green chemistry applications.

The application of an environmentally friendly enzyme in the prevention and control of algal blooms in lakes. Wherein, the environmental protection enzyme has the effect of inhibiting the abnormal increase of TN caused by algae proliferation; or, the environmental protection enzyme has the effect of inhibiting the abnormal increase of pH caused by algae proliferation; or, the environmental protection enzyme has Improve the water quality of the water environment. And an application of an environment-friendly enzyme in the preparation of an algal bloom inhibitor, wherein the environment-friendly enzyme is prepared by putting fruits and / or vegetables, water, and carbohydrates in proportion to fermentation in a closed container. The algae are Microcystis aeruginosa, Scenedesmus tetracerus and / or Navicula rhinocephalum. The present invention finds that the environmentally friendly enzyme is used for the first time to prevent and control the harm of algal blooms in lakes, and has a significant effect on inhibiting the growth of algae; in addition, the preparation method of the environmentally friendly enzyme / algal bloom inhibitor is simple, low in cost, easy to industrialized operation, and can also avoid the occurrence of Secondary pollution.

A security element for securing value documents comprises a first polymer containing a feature substance, which is at least partially surrounded by a second polymer, wherein the first polymer is a hydrophobic, water-insoluble polymer which, at an elevated pH value and at elevated ambient temperature at a treatment duration of less than 60 minutes can be converted into a hydrophilic, water-soluble polymer. The security elements also contains a second polymer, which is a hydrophilic, water-soluble polymer, wherein the elevated pH value is greater than 12 and the elevated ambient temperature is greater than 90° C.

A stannous methanesulfonate solution for tin electroplating applications and a method of forming the same are disclosed. The solution has an elevated pH. The solution also has a sufficient tin concentration for electroplating applications.

A pharmaceutical composition comprising proton pump inhibitors and prebiotics is proposed for the treatment of gastric and duodenal ulcer, this allowing effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum antibiotics. The comprehensive treatment of ulcer disease associated with a helicobaterial infection using a pharmaceutical composition of a PPI and a prebiotic makes it possible, in conditions of an elevated pH of the stomach contents, actively to stimulate the growth of lactobacilli in the upper sections of the gastrointestinal tract, including the duodenum, and substantially to increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment. The high clinical effectiveness and safety resulting from the synergistic action of the proton pump inhibitor and the prebiotic in the upper sections of the gastrointestinal tract, the absence of side effects and recurrences, and also the level of compliance to the combined treatment provided by the claimed pharmaceutical composition indicate that the proposed formulation is a promising new means for the treatment of gastric and duodenal ulcer. Use of the claimed composition dramatically reduces the number of recurrences of the illness.

Disclosed is an antimicrobial composition containing an active halogen-containing component having a source of an active halogen and having an elevated pH, which is mixed with an acidic component. An acidic component is added in an amount to the active halogen-containing component to reduce the pH of the antimicrobial composition. When the pH of the active halogen-containing composition is reduced, the resulting composition has been discovered to be effective as a disinfectant and, particularly, as a sporicide. Application methods for applying the composition are also described.

Disclosed is an antimicrobial composition containing an active halogen-containing component having a source of an active halogen and having an elevated pH, which is mixed with an acidic component. An acidic component is added in an amount to the active halogen-containing component to reduce the pH of the antimicrobial composition. When the pH of the active halogen-containing composition is reduced, the resulting composition has been discovered to be effective as a disinfectant and, particularly, as a sporicide. Application methods for applying the composition are also described.

A method of treating biofilm disease using a pH adjusted therapeutic rinse that comprises two parts that are separated and in amounts that upon mixing provide a single dose. The two parts together and then rinsing a patient's mouth with the single dose and expectorating.