30 results about "Carotid internal artery" patented technology

Interventional procedures on the carotid arteries are performed through a transcervical access while retrograde blood flow is established from the internal carotid artery to a venous or external location. A system for use in accessing and treating a carotid artery includes an arterial access device, a shunt fluidly connected to the arterial access device, and a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. The flow control assembly includes one or more components that interact with the blood flow through the shunt.

The invention provides a preparation method for a mouse thrombotic stroke model. The method comprises the following steps: after anesthetizing a mouse, making a slipknot on a common carotid artery byusing a suture line, and separating and permanently ligating an external carotid artery and a pterygopalatine artery; separating the initial part of an internal carotid artery; putting the common carotid artery into a groove of a blood vessel electric shock clip of a thrombus generator, and carrying out electrical stimulation to form a thrombus; taking off the electric shock clip and clipping thedistal end of the common carotid artery; crushing the thrombus by using a pair of microscope forceps, enabling the artery to pulsate again, and impacting and crushing the thrombus; releasing an arteryclip; after expelling the thrombus to enter the internal carotid artery by using the forceps, immediately closing the proximal end of the common carotid artery; and opening all artery clips after pre-set time, so as to form a target thrombus model. The mouse thrombotic stroke model provided by the invention can be applied to researches of treatment medicines and methods for stroke, and pathogenesis.

The invention is suitable for the technical field of image processing, and particularly relates to a cerebral artery wave intensity and wave power measuring method, terminal equipment and a computer readable storage medium. The measuring method comprises the following steps: acquiring a nuclear magnetic resonance image containing brain information and neck information, and constructing a cerebral hemodynamic model according to the nuclear magnetic resonance image; and obtaining target ultrasonic flow velocity frequency spectrum waveforms of the left internal carotid artery, the right internal carotid artery, the left vertebral artery and the right vertebral artery respectively, and determining the wave intensity and the wave power of each cerebral artery according to the cerebral hemodynamic model and each target ultrasonic flow velocity frequency spectrum waveform. According to the embodiment of the invention, the measurement of the WI and WP of the whole cerebral artery is realized in a mode of combining non-invasive measurement and numerical simulation, so that the accuracy of the measurement of the WI and WP of the cerebral artery is greatly improved, and the method has relatively high usability and practicability.

The invention relates to an embedded type intelligent controllable blood vessel locking device. The embedded type intelligent controllable blood vessel locking device comprises a shell, an actuator and a control module, wherein the shell accommodates the blood vessel and carries the actuator and the control module; the control module provides electric energy and a control signal for the actuator;the actuator comprises a fixed part, an electrical activity polymer material and a movable part, after electrifying, the electrical activity polymer material deforms and drives the movable part to move, the blood vessel accommodated in the shell is squeezed, so that the blood vessel is gradually locked. The embedded type intelligent controllable blood vessel locking device is designed aiming at the demand of treating intracranial aneurysm, basicranial tumor or other brain diseases, and the defects in the existing methods that lesion blood-supply internal carotid is blocked in advance before treatment. The embedded type intelligent controllable blood vessel locking device can be completely implanted in the body, wrap the blood vessel, and slowly lock the internal carotid in a controlled manner, so that the blood-supply brain tissue of internal carotid can obtain compensatory blood supply of other blood vessels, the dependence on the artery is eliminated, then the internal carotid is cutoff, so that cerebral infarction can not be caused, and conditions are created for disease treatment.

The invention provides a construction method of a mouse ischemic stroke model. According to the construction method, current stimulation is given to a Common carotid artery (CCA) of a mouse to form a thrombus embolus, the thrombus embolus is activated, the thrombus embolus is made to spontaneously enter the cranium through an Internal carotid artery (ICA), the intracranial Middle artery (MCA) is blocked, and then acute brain blood supply blocking and brain dysfunction are caused. The invention also provides an evaluation method of the mouse ischemic stroke model. The evaluation method comprises the following steps: marking the thrombus embolus formed on the CCA by using a near-infrared fluorescent molecular probe, tracking the position of the thrombus embolus in the mouse cranium by using a small animal living imaging instrument, and evaluating the ICA clogging degree by using fluorescence intensity.

The invention relates to an embedded controllable blood vessel shutting device. The device comprises a shell, an actuator and a control module, the shell can be freely opened or closed, and the bloodvessel can be partly contained or moved out of the shutting device when the shell is opened; the control module is used for providing electric energy and control signals for the actuator; the actuatoris located between an inner tube and the shell, and the actuator is powered on and can expand, deform and compress the blood vessel, so that the tube wall of the inner tube is deformed and then the blood vessel which is contained in the inner tube is compressed. The embedded controllable blood vessel shutting device is designed aiming at the requirements for treating intracranial aneurysm, skullbase neoplasms or other brain diseases and the defects of an existing method that the lesion blood supply internal carotid is cut off in advance. The device can be completely implanted into the humanbody and can wrap the blood vessel, and the internal carotid can be controllably and slowly shut. In the gradual shutting process, the brain tissue for blood supply of the internal carotid can obtaincompensatory blood supply of other blood vessels and get rid of the dependence of the internal carotid, cerebral infarction cannot be caused when the internal carotid is cut off, and conditions are created for disease treatment.

The invention relates to an implantable controllable blood vessel locking device. The implantable controllable blood vessel locking device comprises a shell, an actuator and a control module, whereinthe shell accommodates the blood vessel and carries the actuator and the control module; the control module provides electric energy and a control signal for the actuator; the actuator comprises sliderails, a roll shaft and an electrical activity polymer material, after electrifying, the electrical activity polymer material deforms and stretches along the slide rails, so that the roll shaft is compressed to move along the slide rails, and the roll shaft extrudes the blood vessel, so that the blood vessel is gradually locked. The implantable controllable blood vessel locking device is designedaiming at the demand of treating intracranial aneurysm, basicranial tumor or other brain diseases, and the defects in the existing methods that lesion blood-supply internal carotid is blocked in advance before treatment. The device can be completely implanted in the body, wrap the blood vessel, and slowly lock the internal carotid in a controlled manner, so that the blood-supply brain tissue of internal carotid can obtain compensatory blood supply of other blood vessels, the dependence on the artery is eliminated, then the internal carotid is cut off, so that cerebral infarction can not be caused, and conditions are created for disease treatment.

The invention discloses a novel construction method of a cerebral metastatic tumor animal model through carotid artery injection, and relates to the field of animal model construction methods. Comprising the following steps: 1) permanent ligation of the external carotid artery; (2) temporarily blocking the proximal end of the common carotid artery; 3) injecting tumor cells into the common carotid artery; 4) temporarily blocking the telecentric end of the common carotid artery to prevent blood backflow; 5) repairing an injection puncture point with hydrogel; and 6) sequentially loosening the blocking of the telecentric end and the proximal end of the common carotid artery. According to the modeling method, the needed time is short, the technical means difficulty is low, the internal carotid artery is kept unobstructed in the mode of ligating the external carotid artery, intracranial hemodynamics is not obviously changed, the death rate and the postoperative cerebral infarction rate caused by the traditional modeling process are greatly reduced, and the modeling method is suitable for large-scale popularization and application. The process is closer to the process that peripheral tumors enter the encephalic through the internal carotid artery and are colonized in the natural state.

The invention relates to the technical field of animal model construction, and discloses a construction method of a novel brain metastatic tumor animal model. The construction method disclosed by the invention comprises the following steps: separating a left common carotid artery and a left common carotid artery branch of the neck of a mouse; rotating the head of the mouse, lifting up a common carotid artery traction silk suture, and then temporarily blocking the common carotid artery; lifting up the telecentric end of the external carotid artery, and leading tumor cell suspension into an internal carotid artery towards the proximal end; and after completing leading in the tumor cell suspension, closing an external carotid artery, and opening the common carotid artery. According to the construction method, the pathophysiological process of human tumor brain metastasis is well simulated, the bleeding amount and the probability of tumor cell leakage in the modeling operation are reduced, the modeling success rate is increased, and the death rate of a model is reduced; and the prepared brain metastasis tumor animal model avoids metastasis of multiple organs, the whole-body tumor load of the mouse is reduced, and the mouse model prepared by the construction method can be used for researching the metastasis mechanism and tumor microenvironment of the brain metastasis tumor.

The invention belongs to the technical field of medical instruments, and particularly relates to a covered stent. The covered stent comprises a stent body and a filter membrane; the stent body is provided with a near end and a far end, and the near end is used for being arranged on the upstream of a blood vessel relative to the far end. The filter membrane is provided with a mounting part and a dissociation part, the mounting part is connected to the stent body, and the dissociation part is connected with the mounting part and dissociates from the stent body. After the stent body is installedat a Y-shaped bifurcation of a carotid artery, the stent body is opened, the filter membrane is opened along with the stent body, and the filter membrane covers plaques in blood vessels, so that the plaques can be prevented from being broken and falling off due to extrusion of the stent body. Besides, after the stent body is installed on the common carotid artery and the internal carotid artery, blood flow entering the external carotid artery from the common carotid artery easily rushes through the filter membrane located at the entrance of the external carotid artery, and therefore it is guaranteed that the blood normally enters the external carotid artery. Compared with the prior art, the covered stent is better in use safety.

The invention discloses a construction method of a brain metastatic cancer animal model and a medical application of the brain metastatic cancer animal model, and the internal carotid artery injection brain metastasis cancer mouse model better conforming to the normal physiological characteristics of the human body is constructed for the first time, and compared with a brain metastasis cancer animal model reported in the field at present, the brain metastasis cancer animal model constructed by the method better conforms to the normal physiological characteristics of the human body; the invention provides a brand-new brain metastasis animal model of a non-human mammal for the field, and the model can be used for researching pathogenesis of brain metastasis and can be used for screening of new drugs and effectiveness testing.

The integrated thrombectomy stent comprises an integrally-formed stent body, the two ends of the stent body are the near end and the far end respectively, the diameter of the stent body is evenly and gradually reduced from the near end to the far end, and at least one far-end marker is arranged at the far end; the stent is respectively provided with a far-end part, a gradual change part and a near-end part which are connected from the far end to the near end, the diameter of the far-end part is 2-4mm, the diameter of the near-end part is 5-7mm, and the taper included angle of the gradual change part is 3-34 degrees; the pushing rod is connected with the near end of the support through the near-end marker, and the pushing rod is pushed to drive the support to move along the microcatheter. According to the thrombus extraction stent, thrombus can be rapidly extracted, the thrombus extraction stent completely conforms to an anatomy structure from the internal carotid artery to the middle cerebral artery M1 section of a Chinese person, when the thrombus extraction stent enters a target position, deformation of blood vessels is reduced, and operation safety is improved.

The invention relates to an intravascular stent applied to carotid artery. The intravascular stent comprises a tubular stent body formed by butt joint of a common carotid artery stent section and an internal carotid artery stent section. The intravascular stent is characterized in that the internal carotid artery stent section is arranged to be of a first conical structure which is matched with aninternal carotid artery blood vessel of a human body in shape and extends upwards in an axial conical mode, and the area of the upper-end cross section of the first conical structure is smaller thanthat of the lower-end cross section of the first conical structure; the common carotid artery stent section is arranged to be of a second conical structure or a straight-barrel-shaped structure whichis matched with the common carotid artery blood vessel of the human body in shape and extends upwards in an axial conical mode, the upper end of the second conical structure and the lower end of the first conical structure are consistent in size and inclination, and the upper end of the straight-barrel-shaped structure and the lower end of the first conical structure are consistent in size; the tubular stent body comprises an inner-layer stent and / or an outer-layer stent; and a first mesh structure and a second mesh structure are arranged on the surface of the inner-layer stent and the surfaceof the outer-layer stent respectively, and an overlapping area exists between the first mesh structure and the second mesh structure.

The invention discloses an extravascular protection support which comprises a roll booster, a hollow protection tube and a hollow separator. The roll booster, the hollow protection tube and the hollow separator are sequentially arranged, a protection gap which is parallel to the central axis of the protection tube and penetrates through the two ends of the protection tube is formed in the side wall of the protection tube, a separation gap penetrating through the two ends of the separator is formed in the side wall of the separator, and the protection gap and the separation gap are centrally and linearly arranged. The separator and the protection tube are arranged, when the support is used, after the arteria carotis communis bifureation is separated through the submandibular incision, the internal carotid is exposed out, the internal carotid is sequentially wrapped by the separator and the protection tube, the separation gap and the protection gap are towards the outer side, the closed walls are towards the inner side, and exactly face the surgical operation direction, surgeons can fully and boldly remove diseased tissue in the operation, the accident that the internal carotid is accidentally injured, and the massive haemorrhage happens can be avoided, and the surgical treatment is improved.

The invention discloses an endoscopic para-pharyngeal space tumor excision method. The method comprises the following steps of dividing a conical structure of a para-pharyngeal space into two parts, namely an upper para-pharyngeal space and a lower para-pharyngeal space by taking a hard palate level as a boundary, and dividing the upper para-pharyngeal space into a front inner sub-region, a frontouter sub-region, a rear inner sub-region and a rear outer sub-region along a sagittal plane and a coronal plane by an axis of the internal carotid artery, and before an operation, selecting a properoperation approach according to the sub-region where the tumor body is located. The method has the beneficial effects that different endoscopic surgery approaches are selected according to the sub-region where the tumor body is located before the operation, the endoscopic surgery mode is adopted, the surgery view is fully exposed, intraoperative bleeding and surgical injuries are reduced, the occurrence and recurrence rate of postoperative complications is reduced, and the prognosis of a patient is improved.

The disclosure includes a balloon guiding sheath including an elongated sheath having a proximal end, a distal end, an inner tube and an outer tube both extending between the proximal end and the distal end, an access port located adjacent the proximal end, a distal port located adjacent the distal end, and a working lumen extending through the elongated sheath between the access port and the distal port. The balloon guiding sheath may include an inflatable balloon located on an outer surface of the elongated sheath adjacent the distal end, and at least one vent hole located between an outer surface of the elongated sheath and an inner surface of the inflatable balloon. The at least one vent hole may be configured to allow media to flow from the inflatable balloon to an external portion outside the balloon guiding sheath.

A method of extracting a thrombus from a thrombus site in a cerebral artery of a patient by advancing a first catheter into an internal carotid artery of the patient; advancing a funnel catheter within the first catheter; moving the funnel catheter and the first catheter with respect to each other to place the funnel outside of the first catheter; expanding the funnel into contact with an inner wall of the internal carotid artery at or proximal to a distal end of a carotid siphon, thereby reducing blood flow past the funnel; advancing a clot-mobilizer distally through the first catheter toward the thrombus and beyond the carotid siphon; engaging thrombus material from the thrombus with the clot-mobilizer; moving the clot-mobilizer and thrombus material proximally at least partially into the funnel; applying suction to aspirate thrombus material; and moving the funnel, the clot-mobilizer and the thrombus material proximally within the vasculature.

The disclosure includes a balloon guiding sheath including an elongated sheath having a proximal end, a distal end, an inner tube and an outer tube both extending between the proximal end and the distal end, an access port located adjacent the proximal end, a distal port located adjacent the distal end, and a working lumen extending through the elongated sheath between the access port and the distal port. The balloon guiding sheath may include an inflatable balloon located on an outer surface of the elongated sheath adjacent the distal end, and at least one vent hole located between an outer surface of the elongated sheath and an inner surface of the inflatable balloon. The at least one vent hole may be configured to allow media to flow from the inflatable balloon to an external portion outside the balloon guiding sheath.

The invention belongs to the technical field of medical instruments, and particularly relates to a variable-aperture covered stent. The variable-aperture covered stent comprises a stent body and a filter membrane, wherein the stent body comprises a near end part, a far end part and a middle part located between the near end part and the far end part in the blood flow direction, the near end part is used for being installed on a common carotid artery, the middle part is used for being opposite to an inlet of an external carotid artery, and the far end part is used for being installed on an internal carotid artery; the filter membrane is connected with the stent body and comprises a near-aperture section, a far-aperture section and a middle-aperture section located between the near-aperturesection and the far-aperture section; and the near-end part is covered with the near-aperture section, the far-end part is covered with the far-aperture section, the middle part is covered with the middle-aperture section, the hole area of the middle-aperture section is larger than that of the near-aperture section and the far-aperture section, and therefore, plaques on the common carotid artery and plaques on the internal carotid artery can be prevented from falling off and flowing to the downstream of blood vessels, and the blood can normally enter the external carotid artery. The variable-aperture covered stent is higher in safety.

The invention provides a Y-shaped carotid artery stent with absorbable branches from the stenosis, which is used for the treatment of carotid artery stenosis. On the outer wall; the membrane tube is installed between the inner network tube and the outer network tube and sleeved on the outer wall of the inner network tube, wherein the inner network tube, the outer network tube and the membrane tube all have a main body, a first branch and a For the second branch on the opposite side, one end of the main body is connected to the end of the corresponding first branch and the corresponding second branch respectively, forming an integral Y shape that matches the shape of the bifurcation structure. For placement in the common carotid artery, the corresponding first branch is used for placement in the internal carotid artery, and the corresponding second branch is for placement in the external carotid artery. Both the inner and outer mesh tubes are made of memory metal wires In the manufactured pipe with a network structure, the pore size of the inner network pipe is smaller than the pore size of the outer network pipe.

An interventional system that utilizes a carotid chemoreceptor(s) and optionally baroreceptor(s) for inducing vasodilatation in blood vessels of the brain is provided for treating ischemic conditions of the CNS, such as ischemic stroke and cerebral vasospasm. The system includes an electrical signal generator and an endovascular module with electrode units for transiently being disposed in the internal and external carotid arteries, adjacent a carotid body.

The invention belongs to the technical field of medical instruments, and particularly relates to a covered stent. The covered stent includes a stent body and a thin film, wherein the stent body comprises a near end and a far end, and the near end is arranged in the upstream position of a blood vessel relative to the far end. The thin film is installed on and covers the stent body, and a pluralityof openings are formed in the surface of the thin film and face the near end or the far end of the stent body. After the stent body is mounted at a Y-shaped bifurcation of a carotid artery, the stentbody is opened, and the film is opened along with the stent body and covers plaques in the blood vessel, so that the plaques can be prevented from being broken and falling off due to extrusion of thestent body. Besides, after the stent body is installed on the common carotid artery and the internal carotid artery, blood flow entering the external carotid artery from the common carotid artery easily rushes through the thin film located at the entrance of the external carotid artery, and therefore the blood is ensured to normally enter the external carotid artery. In conclusion, the use safetyof the covered stent is better.

The invention discloses a human visual conduction path, a blood supply integrated display sample and a manufacturing method thereof. A sample is used for integrally and stereoscopically displaying a visual organ, the visual conduction path and blood supply of the visual conduction path. The manufacturing method includes the steps of obtaining an adult neck sample, injecting anticoagulant water solution into a blood vessel by an internal carotid cannula, discharging blood in the blood vessel through veins, injecting a filler into the blood vessel, removing a skull base after the solidification of the filler, removing meninges, boiling the sample in medicinal water, and then sequentially dissecting each structure and the blood vessel of the visual conduction path from front to back. The advantages of the invention are as follows: a medicinal water boiling method is adopted matching with the blood vessel injection technology and the retina transparent technology, so as to display the three-dimensional space and shape of the visual conduction path from the skull base to the upper part, thereby providing visualized morphological basis for clinical teaching and scientific research.

The series balloon catheter comprises a first balloon structure, an adjusting rod is installed on the right side of the first balloon structure, a communicating pipe is installed on the side, away from the first balloon structure, of the adjusting rod, meanwhile, a second balloon structure is installed on the right side of the communicating pipe, and an air inlet end is installed on the side, away from the communicating pipe, of the second balloon structure; a handle structure is mounted at the bottom of the air inlet end; the working mode of the second balloon structure is consistent with that of the first balloon structure, and a rear balloon of the second balloon structure wraps the outer side of the rear air spraying pipe. The series balloon catheter is provided with two balloons, namely the front balloon and the rear balloon, one balloon is used for expanding a narrow blood vessel during slow closure and recanalization or severe stenosis, the other balloon is arranged at the far end of the C1 section of the internal carotid artery and can block blood flow, opening and closing of the two balloons can be switched back and forth by pressing the stress strip, and the series balloon catheter has the advantages of being easy to operate, convenient to use and high in practicability. And the operation process is simplified.

The invention discloses a human visual conduction path, a blood supply integrated display sample and a manufacturing method thereof. A sample is used for integrally and stereoscopically displaying a visual organ, the visual conduction path and blood supply of the visual conduction path. The manufacturing method includes the steps of obtaining an adult neck sample, injecting anticoagulant water solution into a blood vessel by an internal carotid cannula, discharging blood in the blood vessel through veins, injecting a filler into the blood vessel, removing a skull base after the solidificationof the filler, removing meninges, boiling the sample in medicinal water, and then sequentially dissecting each structure and the blood vessel of the visual conduction path from front to back. The advantages of the invention are as follows: a medicinal water boiling method is adopted matching with the blood vessel injection technology and the retina transparent technology, so as to display the three-dimensional space and shape of the visual conduction path from the skull base to the upper part, thereby providing visualized morphological basis for clinical teaching and scientific research.

The invention discloses a blood flow simulation model of cerebral vessels under the simulated weightlessness condition, and belongs to the technical field of physiologic signal simulation. The model comprises an aorta canal, an brachiocephalic artery canal, a carotid canal, a subclavian artery canal, a vertebrarterial canal, an internal carotid canal, an external carotid artery canal, a basilar artery canal, an arteria cerebri media canal, an arteria cerebri anterior canal, a posterior cerebral artery canal, an anterior communicating artery canal and a posterior communicating artery canal, wherein the aorta canal, the brachiocephalic artery canal and the subclavian artery canal form a systemic circulation arterial rete; blood flows from the systemic circulation arterial rete to the carotidcanal and the vertebrarterial canal, then flows into a cerebral circulation arterial rete formed by the internal carotid canal, the external carotid artery canal, the basilar artery canal, the arteria cerebri media canal, the arteria cerebri anterior canal, the posterior cerebral artery canal, the anterior communicating artery canal and the posterior communicating artery canal; and the tail end of the cerebral circulation arterial rete is the downstream of the arteria cerebri media canal, the downstream of the arteria cerebri anterior canal, and the downstream of the posterior cerebral arterycanal. Through the adoption of the blood flow simulation model disclosed by the invention, the analysis of the interaction of the arterial blood flow of the systemic circulation and the cerebral circulation is deeper.

The invention discloses an umbrella-shaped protective stent for internal carotid artery integrated release, which includes a guide wire, a protective umbrella sleeve, a protective umbrella, an elastic ring, a drawstring, a fixing block, a stent clamping tube, a placement groove, an elastic stent, and a stent sleeve. The internal artery integrated release umbrella-shaped protective stent has ingenious structure and powerful functions. Through the integrated design of umbrella-shaped storage and stent release, it can effectively avoid the problem that after the traditional stent is released, it is necessary to exit the stent release mechanism first and then go deep into the umbrella recovery mechanism. , which avoids repeated operations twice, and also prevents the risk that the umbrella recovery catheter cannot pass through the release stent, greatly improves the safety of the operation, saves operation time, and finally achieves a good clinical application purpose.

The invention relates to a plaque measurement method and device for removing carotid artery systole and diastole influence, and the method comprises the steps: obtaining carotid artery adventitia data and carotid artery plaque data at a preset segment in a carotid artery ultrasonic image, and the preset segment comprises at least one of a common carotid artery, an external carotid artery and an internal carotid artery; for each preset segment, according to the carotid adventitia data of the preset segment, obtaining amplified carotid adventitia data in the preset segment in a maximum adventitia diastole state; and according to the amplified carotid adventitia data of each preset segment, obtaining actual plaque data of the corresponding segment. According to the invention, when each section of carotid artery is amplified to the maximum diastole state, the plaque data is obtained, so that the influence of carotid artery systole and diastole on plaque measurement is eliminated, and the data accuracy of plaque data measurement is improved.