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38 results about "Anti-ulcer Agent" patented technology

Natural or synthetic Anti-ulcer Agents relieve and reduce the symptoms of ulcers in the stomach and upper small intestine, systemically and locally, by reducing gastric secretion (proton pump inhibitors), neutralizing hyperacidity (alkalinizing agents), or improving healing and protecting the mucosa (sucralfate). Recurrent gastric and duodenal ulcers caused by Helicobacter pylori infections are treated with antibiotic therapy.

Sulfoxide compounds and acetone complexes, and a process for producing the same

The present invention provides acetone complexes of sulfoxide compounds, useful as medicines such as inhibitors of gastric acid secretion and anti-ulcer agents or as intermediates for production of medicines, a process for producing the same and a purification method of using the same.Namely, it is the acetone complexes of sulfoxide compounds or of pharmaceutically acceptable salts thereof represented by the following formula:(wherein R1 represents a hydrogen atom, a methoxy group or a difluoromethoxy group, R2 represents a methyl group or a methoxy group, R3 represents a 3-methoxypropoxy group, a methoxy group or a 2,2,2-trifluoroethoxy group, R4 represents a hydrogen atom or a methyl group, n and m independently represent an integer of 1 to 4, and B represents a hydrogen atom, an alkali metal atom or ½ alkaline earth metal atom), which are obtained by treating the sulfoxide compounds or pharmaceutically acceptable salts thereof with acetone.
Owner:EISIA R&D MANAGEMENT CO LTD

Oral health-care agent capable of clearing away heat and toxic materials, and preparation method thereof

The invention belongs to the scientific and technical field of oral medicine and oral health, and particularly relates to an oral health-care agent capable of clearing away heat and toxic materials, and a preparation method thereof. The oral health-care agent contains a food-grade heat-clearing and detoxicating prescription, an anti-ulcer agent, a caries-prevention agent, a cell adhesion moisturizer, a natural antibacterial and anti-inflammatory agent and an oral health-care agent, preferably, the preparation further contains a preservative, more preferably, the preparation further contains apreparation-acceptable safety carrier or excipients; and all the ingredients are scientifically prepared and optimized to obtain a group of safety and multi-effect compositions which not only can clear away heat and toxic materials and is antibacterial and anti-inflammatory, but also can prevent tooth and periodontium and other oral diseases, and then a convenient and practical oral health-care agent is prepared by adopting a mild technological method. The oral health-care agent capable of clearing away heat and toxic materials not only has medicine efficacy, but also has the safety of health-care food, and is convenient to use, good in efficacy and fast in effect.
Owner:ZHENGZHOU LANCI BIOENG CO LTD

Effervescent compositions comprising bisphosphonates and methods related thereto

The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
Owner:ATENEUM AB REG NO 556521 4391

Effervescent compositions comprising bisphosphonates and methods related thereto

The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
Owner:EFFRX PHARMA SA

Method for preparing omeprazole

ActiveCN101070315AGood directional oxidationShort reaction timeOrganic chemistryKetoneAnti-ulcer Agent
This invention relates to preparation method of a antiulcer drug. The invention takes pyrmetazole that chemical name is 5 - methoxyl group - 2 - { [ ( 4 - methoxyl group - 3, 5 - dimethyl - 2 - pyridyl) methyl] sulfinyl} - 1 hydrogen - benzimidazole as raw material, takes IBX that chemical name is 1 - hydroxy - 1, 2 - benzene iodine acyl - 3 ( 1 hydrogen) - ketone - 1 - oxide as oxidizer, and takes quaternary ammonium salt compound tetraethyl ammonium bromide or tetrabutyl ammonium bromide as catalyzer, to synthesize antiulcer drug omeprazole. The invention also relates to the according reclaim measure of oxidizer.
Owner:ZHEJIANG MENOVO PHARMA

Toothpaste with functions of resisting helicobacter pylori in oral cavity, preventing caries and invigorating stomach and preparation method of toothpaste

The invention provides an oral toothpaste with anti-helicobacter pylori and anti-caries and stomach-enhancing functions. The toothpaste contains bismuth glycyrrhizinate at a concentration of 0.001% to 10% by weight. Bismuth Glycyrrhizinate combines the anti-inflammatory, analgesic, anti-ulcer, anti-oxidation effects of glycyrrhizic acid and the gastric mucosal protection function of bismuth. The bismuth glycyrrhizinate toothpaste of the present invention is a kind of daily oral hygiene article, practical and convenient, multi-effect of one product, can effectively kill HP and cariogenic bacteria, simultaneously bismuth glycyrrhizinate is dental plaque inhibitory and cleaning agent, thereby helps to inhibit and remove dental plaque, reduce the chance of bacterial adhesion and aggregation, and treat both symptoms and root causes; making it into toothpaste for external use can effectively, conveniently and durably kill Helicobacter pylori in the oral cavity, thereby effectively preventing gastrointestinal The purpose of treating tract infection and preventing the recurrence of gastritis, gastric and duodenal ulcers.
Owner:高勇

Sesquiterpenoid anti-ulcer drug, preparation method and application

The invention relates to a sesquiterpenoid anti-ulcer drug which is prepared from bisabolangelone and derivatives thereof. The invention further provides a preparation method of the bisabolangelone and the derivatives thereof, and the sesquiterpenoid anti-ulcer drug is applied to preparation of a drug for preventing and treating a gastric ulcer and a duodenal ulcer. Experimental results prove that the sesquiterpenoid anti-ulcer drug has the better inhibition ratio on an H<+> / K<+>-ATP enzyme.
Owner:CHINA THREE GORGES UNIV

Qi stagnation stomachache particle anti-ulcer quality control method based on dose-effect color card

ActiveCN105738519AQuality improvementControl the quality of traditional Chinese medicineComponent separationBiological testingAdditive ingredientAnti-ulcer Agent
The invention relates to a qi stagnation stomachache particle anti-ulcer quality control method based on a dose-effect color card. According to the quality control method, by means of establishment of a qi stagnation stomachache particle fingerprint spectrum and efficacy evaluation of the qi stagnation stomachache particle anti-ulcer effect, the quality and efficacy relevance of qi stagnation stomachache particles is evaluated, a dose-effect relation equation is established, the qi stagnation stomachache particle anti-ulcer action dose-effect color card is successfully established, and thus it is achieved that by detecting the relative peak area of specific ingredients in the qi stagnation stomachache particles, the anti-ulcer efficacy of the qi stagnation stomachache particles can be visually reflected in the color card mode, and the quality control method can be used for evaluating the degree of the anti-ulcer effect performed by the qi stagnation stomachache particles and the quality of the qi stagnation stomachache particle.
Owner:本溪国家中成药工程技术研究中心有限公司

Anti-gastritis and anti-ulcer agent containing momordicae semen extract and momordica saponin i isolated from the same

InactiveCN101340920AAvoid damagePreventing and Treating DamageAntipyreticDigestive systemGastritisMomordica
The present invention relates to a Momordicae semen extract effective in the prevention and treatment of gastritis or gastric ulcer and momordica saponin I isolated therefrom. The Momordicae semen extract and the momordica saponin I isolated therefrom is effective in the prevention and treatment of gastritis or gastric ulcer since they prevent the damage of the gastric mucosa caused by alcohols and inhibit the secretion of gastric acid.
Owner:SK CHEM CO LTD

Traditional Chinese medicine preparation for treating peptic ulcer, gastritis and reflux esophagitis and preparation method and application thereof

The invention provides a traditional Chinese medicine preparation for treating peptic ulcer, gastritis and reflux esophagitis as well as a preparation method and an application thereof. The traditional Chinese medicine preparation provided by the invention is prepared by the steps of: roasting and crushing coptis chinensis, rheum officinale, pseudo-ginseng and bletilla; mixing the optis chinensis, rheum officinale, pseudo-ginseng and bletilla with Yunnan Baiyao in a weight ratio; and adding medicinal auxiliary materials in a medicinal amount. Through scientific proportioning and clinic observation, the formula provided by the invention can effectively and safely treat peptic ulcer, gastritis and esophagitis of all kinds and reflux esophagitis, and is remarkable in curative effect, low in recurrence rate and free of toxic and side effects; the action and curative effect of the preparation can be comparable to those of an anti-ulcer agent, a gastric motor drug, a gastric mucosa protective agent and an anti-helicobacter pylori western medicine. The traditional Chinese medicine preparation provided by the invention has various functions of western medicine in clinical treatment and is the most effective traditional Chinese medicine formula for treating peptic ulcer, gastritis and esophagitis, improving the clinical symptoms and radically treating ulcer and preventing relapse in traditional Chinese medicine treatment at present. A purpose of treating both causes and symptoms is achieved.
Owner:HUBEI UNIV OF TECH

Salts Of Benzimidazole Derivative With Amines And Process For Manufacturing The Same

It is an object of the present invention to provide (1) a process for manufacturing alkali metal salts of 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole which are useful as gastric acid secretion inhibitors, anti-ulcer agents and other drugs and (2) salts of 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole with amines which are intermediates for the production of the alkali metal salts, and a process for manufacturing the same. According to the present invention, disclosed are salts represented by the following formula (I): (wherein A+ represents an isopropylammonium ion, sec-butylammonium ion or cyclopentylammonium ion).
Owner:EISIA R&D MANAGEMENT CO LTD

Effervescent compositions comprising phosphonates and methods related thereto

The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
Owner:EFFRX PHARMA SA

Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agent

InactiveUS20120172380A1Using treatment methodBiocideOrganic active ingredientsAnticarcinogenAnti-ulcer Agent
The invention relates to substituted 4-(tetrazol-5-yl)-quinazoline derivatives of the formula-I,or pharmaceutically acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted 4-(tetrazol-5-yl)-quinazoline derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man.
Owner:NATCO PHARMA LTD

Compounds for use as Anti-ulcer agent and/or Anti-helicobacter pylori agent and pharmaceutical compositions thereof

The present invention relates to a compound according to formula Iin particular as anti-ulcer agent and / or anti-Helicobacter pylori agent, wherein R1 is selected from linear or branched C1-C6 alkyl, H, thioether and benzyl, and R2 is selected from linear or branched C1-C10 alkanediyl and pharmaceutical compositions thereof
Owner:KING SAUD UNIVERSITY

Novel therapeutic agent derived from marine organism

There is provided a nerve repairing agent, anti-ulcer agent or the like comprising an extract from a marine organism selected from organisms belonging to the class Holothuroidea, the phylum Porifera and the order Actiniaria or a material removed from a viscus of the organism. The extract has the following properties (1) to (4): (1) it is a almost colorless, transparent and viscous liquid having a slight fishy smell, or a almost white powder having a slight fishy smell which, when dissolved in water, is almost colorless and viscous; (2) a solution prepared by dissolving the liquid or powder in water shows the maximum absorbance at a wavelength of 264±10 nm; (3) a solution prepared by dissolving the liquid or powder in water shows an acidic pH value; and (4) it has at least one effect selected from a cranial nerve repairing effect, a nerve-growing effect, an insulin-releasing effect, an immunopotentiating effect, a noxious pain preventive effect, a neurogenic pain preventive effect, a diabetic sensory neuropathy ameliorating effect and an ulcer preventive effect.
Owner:IMEX JAPAN

Application of coumpound baicalin-zinc in preparing medicament for resisting peptic ulcer

The invention relates to new application of compound baicalin-Zn in preparing drugs for resisting peptic ulcers. The baicalin-Zn is prepared into granules, or capsules, or tablets, or pills as drugs or health-care products for treating the peptic ulcers. Preferably, 0.05-0.5 milligram of the drug is orally taken each time and twice or three times each day. The invention shows that the baicalin-Zn has good protection functions to water irritability mouse gastric ulcers and reserpine induced rat gastric ulcers and has equivalent effect to the primary anti-ulcer drug omeprazole usually used in clinics while dosage thereof is only 1 / 80 of the omeprazole. As an orally taken drug and health-care product in the treatment of peptic ulcers, the compound baicalin-Zn has the characteristics of high effect, low toxicity and good development and application prospects as a drug prepared for treating the peptic ulcers.
Owner:KUNMING MEDICAL UNIVERSITY

Medicament for preventing and controlling stomach diseases

The present invention relates to a medicine used for curing and preventing gastrosis, which comprises lanthanum orthophosphate and auxiliary ingredient acceptable in medicine jointly, or serves as compound type medicine consisting of lanthanum orthophosphate taken as a first medicine ingredient, antacid and / or antimicrobial type ingredient taken as a second medicine ingredient and auxiliary ingredient acceptable in medicine. The lanthanum orthophosphate is simple in preparation process, low in price of raw material and manufacturing cost, low in toxicity, satisfactory in protective effect of stomach mucous membrane with good medicine economics characteristic. The lanthanum orthophosphate can be developed as the new-generation anti-ulcerative medicine.
Owner:成都厚发科技开发有限公司

Use of compounds produced from arrabidaea brachypoda extracts as Anti-ulcerogenic agents

Disclosed is the use of compounds obtained from roots, stem, bark and leaves extracts from plant species of genus Arrabidaea, in particular Arrabidaea brachypoda, also known in Brazil under the names “cipó-una” or “cervejinha do campo”, to treat ulcerogenic diseases.
Owner:UNIV EHSTADUAL PAULISTA KHULIO DE MESKITA FILO UNESP +2

Extracts and isolated flavonoids from euphorbia cuneata useful as Anti-ulcer agents

InactiveUS20130079294A1Easy and flexible purificationEasy to getBiocideSugar derivativesMedicineAnti-ulcer Agent
The present invention relates to flavonoids isolated from Euphorbia cuneata, a method for their isolation, extracts from Euphorbia cuneata and a pharmaceutical composition comprising the flavonoids or the extracts or both of them for a use as anti-ulcer agent.
Owner:KING SAUD UNIVERSITY
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