The invention discloses a multifunctional medicine changing device for orthopedic nursing, and the device comprises a base; a control table is arranged on the base, a seat adjusting button and an illuminating lamp switch are arranged on the control table, a seat base is arranged on the rear portion of the control table, an inner cavity is formed in the seat base, two air cylinders are installed in the inner cavity side by side, and the air cylinders are connected with sliding blocks through air cylinder push rods; the sliding blocks are provided with two adjustable columns, the top ends of the adjustable columns are sleeved with rotating heads, the rotating heads are connected with fixed blocks through connecting rods, and the lower portions of the fixed blocks are connected with rubber pads through elastic bands on the two sides. Compared with the prior art, the medical dressing change device has the advantages that the overall structure is simple and practical, part selection, connection and overall working modes are reasonable, inconvenience in clinical dressing change is greatly reduced, the functions of illumination, storage, placement, observation, dressing change and the like are integrated, medical staff can use the medical dressing change device conveniently, dressing change efficiency is improved, applicability is good, and popularization is convenient.