37results about How to "Safety profile" patented technology

Systems and methods for separating an object such as a pacing lead from a patient tissue involve a flexible and torqueable shaft having an internal lumen sized to receive the object, and a hard separating mechanism for separating the object from the tissue. Typically the shaft and separating mechanism are advanced along or toward the object, and the separating mechanism is contacted with the tissue. The shaft is rotated to effect separation between the object and the tissue. The systems and methods are well suited for use in cardiac pacing or defibrillator lead explant procedures.

Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.

Systems and methods for separating an object such as a pacing lead from a patient tissue involve a flexible and torqueable shaft having an internal lumen sized to receive the object, and a hard separating mechanism for separating the object from the tissue. Typically the shaft and separating mechanism are advanced along or toward the object, and the separating mechanism is contacted with the tissue. The shaft is rotated to effect separation between the object and the tissue. The systems and methods are well suited for use in cardiac pacing or defibrillator lead explant procedures.

The invention relates to methods of treating diseases related to vasodilation, generally comprising administering to an individual an effective amount of a pharmaceutically active relaxin. Relaxin functions to increase both vasodilation and angiogenesis in males as well as females, and is therefore useful in treating a wide variety of diseases relating to vasoconstriction.

The present disclosure describes methods for treating or preventing Type 1 diabetes mellitus in juveniles, particularly in juveniles newly diagnosed with Type 1 diabetes. This prevention or treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin, thereby decreasing the destruction of islet cells, or maintaining endogenous insulin production, in the juvenile.

The invention belongs to a climbing prevention and antitheft device for a balcony and a window of a building and particularly relates to a window warning flower groove and a manufacture method of the window warning flower groove. The window warning flower groove mainly consists of a flower groove and a warning device and is characterized in that a plurality of baffle rods outwards extend from the front side of the long groove-shaped flower groove, and a hinge is arranged at the lower part of the flower groove. The window warning flower groove is arranged outside a window and is blocked on the only way of a thief, the antitheft protection functions of climbing prevention, hanging prevention and the like can be realized, the preventative measures are taken, the window warning flower groove can also be used for culturing flowers, drying objects and preventing unexpected falling of people and objects from high altitude, in addition, the life escape and the disaster cannot be influenced, and the window warning flower groove can be widely used for antitheft protection of various building floors.

The invention relates to the field of medicine, in particular to the field of veterinary medicine. The invention relates to glucocorticoids, especially ciclesonide or a pharmaceutically acceptable derivative or salt thereof, for the treatment of airway disease in horses, such as pulmonary disease, preferably recurrent airway obstruction (RAO), Summer Pasture Associated Obstructive Pulmonary disease (SPAOPD), and inflammatory airway disease (IAD).

Effective and safe pharmaceutical composition and method for treating atrial fibrillation are described. The combined use of dofetilide and mexiletine resulted in an enhanced efficacy in the prevention and treatment of atrial fibrillation with markedly reduced risk of the life-threatening ventricular arrhythmia TdP.

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and / or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated amino acid and (ii) a D-amino acid substitution in position 2. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects.

It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and / or treatment of trans-thyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and / or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and / or treatment of transthyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and / or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

The aim of the invention is to provide a rubber profiled safety strip or an elastic profiled safety strip which can carry out a signaling function. To this end a profiled safety strip (10) is provided for a door (15) of a transport means, wherein the profiled safety strip (10) contains an opaque elastic main part (11) in which at least one receiving region (17, 18) is formed, and in the at least one receiving region (17, 18) an insert strip (12, 31) is disposed, which contains at least one light source (13, 32) and is made of an elastic material that is at least partly transparent.

The invention belongs to an anti-creeping and anti-theft device for balconies and windows of buildings, and particularly relates to a manufacturing method for a window alarm planter. The window alarm planter mainly consists of a planter body and alarm equipment, and is characterized in that a plurality of stop levers extend upwards at the front side of the elongated slot-shaped planter body; the lower part of the planter body is provided with hinges; the window alarm planter is arranged on the outside of a window to block the only way that a thief necessarily passes; the window alarm planter has anti-theft protection functions of creeping prevention, hanging prevention and the like, can take preventive measures, and can also be used for growing flowers, drying objects, and preventing people and objects from falling by accident from high altitude, and moreover, escape or disaster relief is not influenced; the window alarm planter can be widely used for the anti-theft protection of floors of various buildings.

The present invention refers to the strain CECT8538 of Pseudomonas putida and mutants thereof, and the use of said strain as a pesticide in controlling plant diseases caused by fungi and bacteria. Further aspects of the invention relate to methods for preparing pesticidal compositions comprising said strain. Finally, the invention relates to a method for controlling various plant diseases caused by fungi and bacteria in a plant, comprising treating the plant and / or seed thereof or substrate used for growing said plant with the strain CECT8538 of P. putida or a composition including it.

It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and / or treatment of transthyretin-associated amyloidosis. It is also provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and / or treatment of transthyretin-associated amyloidosis in combination therapy with another COMT inhibitor, a benzoxazole derivative, iododiflunisal, diflunisal, resveratrol, tauroursodeoxycholic acid, doxocycline, or epigallocatechin-3-gallate.

Effective and safe pharmaceutical composition and method for treating atrial fibrillation are described. The combined use of dofetilide and mexiletine resulted in an enhanced efficacy in the prevention and treatment of atrial fibrillation with markedly reduced risk of the life-threatening ventricular arrhythmia TdP.

Disclosed is a fabricating method of a cobweb-shaped alarm net. The cobweb-shaped alarm net is mainly composed of warps, wefts and an alarm device and is characterized in that the wefts are distributed spirally around the central point of a plurality of the warps to form the net body and connected with the alarm device. The cobweb-shaped alarm net is a bionic design, is mounted outside a window, has the functions of shearing-resistance, anti-creeping, burglar prevention and protective alarming, avoids accidental high-altitude falling of people or objects, has no influence on escaping and disaster relief and can be widely applied to various building storeys.

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and / or chronic pain. Embodiments of the invention are directed to cyclic analogs of endomorphin. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects.

The present disclosure relates, in general, to methods of treating or preventing post-prandial hypoglycemia after gastric bypass surgery using a negative modulator antibody that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.

The present disclosure describes methods for treating Type 1 diabetes mellitus in juveniles. This treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin.

The invention provides an adjuster for adjusting the roof of a sail house, which comprises a fixed part which is fixedly arranged relative to the sail house and a movable part, wherein the movable part is provided with an adjusting part to form into a first motion direction and a second motion direction which can be self locked and adjusted relative to the fixed part and a lug boss or U cup-shaped tightening part which is contacted with a pull rod of the flexible roof; the fixed part is a fixed block with inner screw thread; the movable part is a rod with external screw thread; and the inner or external adjusting part arranged at the movable part realizes the screw thread motion connection between the fixed part and the movable part, thereby tensioning and loosening the flexible roof. Theadjuster has simple structure, low cost, simple and reliable operation and small use amount, only can be installed at the corner or the middle of the sail house, and can smoothly tension and loose the sail house with the flexible roof, thereby leading the sail house to have technical effects of beautiful appearance, safety and durability, etc.

The present invention refers to the strain CECT8538 of Pseudomonas putida and mutants thereof, and the use of said strain as a pesticide in controlling plant diseases caused by fungi and bacteria. Further aspects of the invention relate to methods for preparing pesticidal compositions comprising said strain. Finally, the invention relates to a method for controlling various plant diseases caused by fungi and bacteria in a plant, comprising treating the plant and / or seed thereof or substrate used for growing said plant with the strain CECT8538 of P. putida or a composition including it.

The invention belongs to a climbing prevention and antitheft device for a balcony and a window of a building and particularly relates to a window warning flower groove and a manufacture method of the window warning flower groove. The window warning flower groove mainly consists of a flower groove and a warning device and is characterized in that a plurality of baffle rods outwards extend from the front side of the long groove-shaped flower groove, and a hinge is arranged at the lower part of the flower groove. The window warning flower groove is arranged outside a window and is blocked on the only way of a thief, the antitheft protection functions of climbing prevention, hanging prevention and the like can be realized, the preventative measures are taken, the window warning flower groove can also be used for culturing flowers, drying objects and preventing unexpected falling of people and objects from high altitude, in addition, the life escape and the disaster cannot be influenced, and the window warning flower groove can be widely used for antitheft protection of various building floors.

A method of treating inflammation includes administering an anti-inflammatory agent to a patient in need thereof. The anti-inflammatory agent is selected from Compound 1 ([(2-{[3-(4-methyl-1H-benzimidazol-2-yl)piperidin-1-yl]carbonyl}phenyl) amino] acetic acid) and Compound 2 (Ethyl-1-(5-cyano-2-hydroxyphenyl)-4-oxo-5-phenoxy-1,4-dihydropyridine-3-carboxylate). Compound 1 and Compound 2 selectively inhibit COX-2 enzyme, without substantially inhibiting COX-1 enzyme, in contrast to many other NSAIDs.

The invention provides a unit common-rail pump assembly for a single cylinder diesel. The unit common-rail pump assembly for the single cylinder diesel comprises a pump body, a main valve seat detachably connected with the pump body, and an oil inlet structure arranged on the main valve seat, wherein a low-pressure oil cavity communicating with the oil inlet structure is arranged in the main valveseat; a proportional electromagnetic valve for controlling the oil inlet amount of the oil inlet structure is arranged in the low-pressure oil cavity; a pump head part communicating with the low-pressure oil cavity and used for oil inlet conveying control is arranged on the pump body; a plunger sleeve connected with the pump head part is arranged on the pump body and is provided with a high-pressure oil cavity communicating with an oil inlet cavity and an oil outlet cavity of the pump head part so as to push oil into the oil outlet cavity; a plunger movably connected with the inner wall of the plunger sleeve and used for providing a pushing force is arranged in the high-pressure oil cavity, and is connected with a drive shaft; and the pump head part is connected with an external oil pipe.Through the unit common-rail pump assembly for the single cylinder diesel provided by the invention, the production cost can be effectively reduced, and the reliability and the service life are improved.

The present disclosure relates, in general, to methods of treating or preventing post-prandial hypoglycemia after gastric bypass surgery using a negative modulator antibody that binds to the insulin receptor and modulates the action of insulin at the insulin receptor.