The invention relates to a safe ultrasonic graphene peeling preparation device based on the Internet of Things, including a controller, a preparation box, a box door, a hinge mechanism, a fixing mechanism and a vacuum mechanism. The vacuum mechanism includes a vacuum box, an air inlet pipe, an air outlet pipe and A closed assembly, a vacuum assembly is provided in the vacuum box, the vacuum assembly includes a first motor, a first drive shaft and two vacuum units, the fixing mechanism includes two fixing units, and the fixing unit includes an insertion ring, an insertion rod, a fixing block, a first Spring and moving plate, the safe ultrasonic graphene peeling preparation device based on the Internet of Things facilitates the rotation of the door through the hinge mechanism, and uses the fixing mechanism to fix the door on the preparation box, so that the preparation box forms a closed environment and blocks the equipment The propagation of ultrasonic waves generated during operation, not only that, the air in the preparation box is extracted through the vacuum mechanism, so that the preparation box forms a vacuum environment, blocking the propagation of ultrasonic waves, thus ensuring the safety of operators.