A mobile cooling system comprises a refrigeration system, a heat exchange system, a pipeline system, a pipe diameter transition system, a power system, a conveying system, an auxiliary system and a command system; all the systems adopt modular design, different systems can be integrated into one module or divided into a plurality of modules, and all or part of the systems can be selected to be integrated into a heat exchange vehicle, a pipeline vehicle, a powered vehicle, a pump vehicle, an auxiliary tool vehicle, a command vehicle and the like or integrated into some vehicles of the heat exchange vehicle, the pipeline vehicle, the powered vehicle, the pump vehicle, the auxiliary tool vehicle, the command vehicle and the like. After a combustible liquid storage tank fire happens, the mobile cooling system is connected into an original conveying pipeline, heated combustible liquid in the fired storage tank is subjected to heat exchanged and cooling and then safely guided out, the practical effect of a valve opening flow guiding method for fire fighting is improved, and economic looses, environmental pollution, secondary accident damage and the social influence which are caused by the fire are reduced.