33results about How to "Particular utility" patented technology

An improved lithographic alignment method, system, and template. The method includes creating, within a lithographic subfield, subsequent-layer features which are intentionally offset from their respective previous-layer features, where the intentional offset may vary in magnitude and direction from one subfield to the next. The system includes an imprint lithographic machine and first and second lithography templates where the templates are adapted to enable the machine to form first and second features, respectively, and where a second feature is configured to be deliberately offset from a corresponding first feature. The template set includes at least two templates, one having features which are deliberately offset from corresponding features of another template. Also, a method of manufacturing such a template set.

The present invention provides a method of preparing content with design in a presentation that is suitable for printing and / or electronic publishing. The method utilises content data including alphanumeric and / or graphical elements, and design data including a rule or rules associated with a particular alphanumeric element or graphical element. This can be used to define a scoring system which defines a score dependent on a degree of conformance of layouts to the rules, with the layout being selected in accordance with the resulting score.

Disclosed are methods and compositions useful in the treatment, augmentation and / or repair of soft and / or hard tissues of animals, and in particular, vertebrates such as humans. The invention provides hydrogel compositions for use in the preparation of medicaments for wound healing, cartilage and meniscus repair, dermal augmentation, and bone fusion, as well as methods for the treatment of intervertebral disc impairment. In particular embodiments, the invention provides compositions useful in restoring hydrodynamic function, increasing intervertebral disc height, and improving proliferation and survival of chondrocytes and other cells in intervertebral discs that have been compromised by injury, degenerative disease, congenital abnormalities, and / or the aging process.

The present invention provides tools and methods designed to aid in the placement of artificial facet joints at virtually all spinal levels. One aspect of the present invention is a measurement tool for installing an artificial cephalad facet joint, the tool including a trial marker having a portion configured to be placed in a hole; and a trial body comprising a bore therethrough for slidaby receiving a portion of the trial marker. In some embodiments, the trial body further comprises an arm extending generally radially outward from the bore and configured to contact an opposing spinal prosthesis component. The trial body may further comprise a lower portion configured to be placed in the hole. The trial marker and the trial body are configured to cooperate to indicate a relative positioning between them. This measurement tool assists in the selection and / or configuration of an artificial cephalad facet joint for implantation in a patient. Another aspect is a method of using a spinal prosthesis component selection tool comprising accessing a target anatomy, creating a hole within a portion of the target anatomy, inserting a marker rod of a component selection tool in the hole, slidably adjusting a trial stem body along the marker rod until the trial body contacts an opposing spinal prosthesis component, determining the relative position between the trial body and marker rod, and selecting a component for implantation into the target anatomy based on the determined relative position.

A plant watering system particularly suited for use in watering indoor, potted plants, includes a plurality of plant watering devices and a main controller. Each plant watering device including a fluid reservoir, a fluid outlet from which fluid may be dispensed to an adjacent plant, and an electronically controlled flow controller controlling the flow of fluid from the reservoir to the outlet. The main controller includes a user input and a control unit configured to generate watering device control signals. Control signals are transmitted from the main controller to each watering device wirelessly.

The invention provides a bleaching composition of pH 8-14 which comprises an oxygen transfer agent and hypochlorite or a source thereof and a method for bleaching a stained substrate which comprises the step of treating the substrate with a bleaching composition of pH 8-14 which bleaching composition comprises an oxygen transfer agent and hypochlorite or a source thereof. Particularly preferred oxygen transfer agents are imine quaternary ammonium salts such as N-methyl-3,4-dihydroisoquinolinium salts. Where these salts are used, suitable counter-ions include halides, sulphate, methosulphate, sulphonate, p-toluene sulphonate and phosphate. Oxygen transfer agents which comprise a quaternary nitrogen atom are preferred. In the alternative, the oxygen transfer agent can be a sulphonimine.

A method of producing a geopolymer product, which comprises: preparing an activated geopolymer premix by addition to a geopolymer premix of an activator compound that initiates a condensation reaction in the geopolymer premix; forming the activated geopolymer premix into a desired configuration to form a geopolymer structure; and curing the geopolymer structure to produce the geopolymer product, wherein the characteristics of the activated premix are controlled and the condensation reaction allowed to proceed for a period of time prior to forming such that when formed the activated premix forms a self-supporting geopolymer structure.

A method for classifying cancer patients as eligible to receive cancer therapy comprising determination of the presence or absence in a patient tissue sample of chromosomal copy number gain at chromosomal locus 18q21-q22. The classification of cancer patients based upon the presence or absence of 18q21-q22 gain allows selection of patients to receive chemotherapy, such as therapy with a Bcl-2 family inhibitor, and for monitoring patient response to therapy.

A method of and system for rapidly locating all passive underground electronic marker types in an area under survey may locate various marker types simultaneously. In accordance with one aspect of the present invention, a marker locator may sequentially transmit and receive multiple frequencies very quickly; alternatively, the transmitter may transmit a broadband signal on multiple frequencies.

A multi-function wire stripping hand tool generally for electricians that has a wire stripping system for a controlled cut and strip of the insulation from a wire. The tool includes an elongated body member having a longitudinal cavity and a transverse opening therein which communicates with the longitudinal cavity and one end of the body member. A stationary cutting blade is disposed in the inner end of the longitudinal cavity, and a movable cutting blade is movably mounted within an upper end of the longitudinal cavity. A spring is disposed between and engaged with a push button actuator so as to urge the movable blade to an open and retracted position. The wire stripping system is engaged with a handle region of the hand tool, and permits stripping in a direction that is perpendicular a longitudinal axis of the multi-function hand tool. The wire stripping system may be used from either side of the hand tool, and may be provided with a plurality of first and second operably engaged housings for securing a number of tool bit members.

An exercise device for strengthening and enlargement of the penis includes a substantially helical spring including a first lever arm, a central spring section having one end integral with one end of the lever arm, and a second lever arm integral with a second end of the spring section, each lever arm having one free end including a retainer element. The device also includes a selectable weight attachable to the spring section and a first flexible elongate pad having a width and length proportioned for engagement about the penis. The device also includes a flexible cord, having opposing ends attached to respective opposite ends of the first pad, passing through the retainer means of the first lever arm. The device also includes a flexible elongate pad having a width and a length proportioned for engagement about the penis, and a flexible cord having opposing ends attached from respective opposite ends of the second pad, the cord passing through the retainer elements of the second lever arm.

The subject invention pertains to novel compounds (and salts thereof), and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns methods of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. This results in an improved safety profile. The new compounds have particular utility for treating life-threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The compounds also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.

A mass spectrometer comprised of a mass analyzer, ion source and detector has the capability of analyzing samples in both positive and negative ionization modes. The mass spectrometer used in conjunction with a liquid chromatograph, fluid splitters and a plurality fluid pathways so that a large volume of analyses may be performed quickly and with high precision and accuracy. The apparatus is also capable of analyzing complex mixtures such as coeluting samples.

A multi-function wire stripping hand tool generally for electricians that has a wire stripping system for a controlled cut and strip of the insulation from a wire. The tool includes an elongated body member having a longitudinal cavity and a transverse opening therein which communicates with the longitudinal cavity and one end of the body member. A stationary cutting blade is disposed in the inner end of the longitudinal cavity, and a movable cutting blade is movably mounted within an upper end of the longitudinal cavity. A spring is disposed between and engaged with a push button actuator so as to urge the movable blade to an open and retracted position. The wire stripping system is engaged with a handle region of the hand tool, and permits stripping in a direction that is perpendicular a longitudinal axis of the multi-function hand tool. The wire stripping system may be used from either side of the hand tool, and may be provided with a plurality of first and second operably engaged housings for securing a number of tool bit members.

The subject invention provides novel compounds for treatment of cardiac arrhythmia and methods of use.

A construction apparatus having a frame adapted to be mounted on a support; at least one work object, having a predetermined upper portion and a lower portion; and an assembly mounting the work object in supported relation on the frame by the upper portion or the lower portion of the work object for substantially lateral movement relative to the support in the performance of a work operation.

A cooling system for use in an engine having an element to be cooled includes at least one cooling channel on a first side of the element, at least one cooling channel on a second side of the element, and the at least one cooling channel on the first side communicating with the at least one channel on the second side in a nose region of the element so as to form a cooling circuit. The cooling system has particular utility in cooling interior and exterior surfaces of a movable cowl inlet flap used in a scramjet engine.

Described herein are stem cells derived from the meninges; specifically, the dura mater, pia mater or arachnoid mater. Methods for isolating, differentiating and explanting these cells are described, as well. In particular embodiments, the stem cells of the present invention are differentiated into nerve cells, bone cells, cartilage cells and Schwann cells. The stem cells of the invention can be taken from a small biopsy, and rapidly expanded to large populations of cells using specially defined media that maintain their undifferentiated state. Use of the stem cells of the present invention in biomedical applications is also described.

A mass spectrometer comprised of a mass analyzer, ion source and detector has the capability of analyzing samples in both positive and negative ionization modes. The mass spectrometer used in conjunction with a liquid chromatograph, fluid splitters and a plurality fluid pathways so that a large volume of analysis may be performed quickly and with high precision and accuracy. The apparatus is also capable of analyzing complex mixtures such as coeluting samples.

Acyclic nucleoside analogs such as acyclovir, ganciclovir, penciclovir and the corresponding pro-drugs, i.e., valacyclovir, valganciclovir and famciclovir, respectively have been identified as inhibitors or antagonists of both telomerase (encoded by TERT) and reverse transcriptase encoded by L-1 (LINE-1) RT, and as useful for treating or preventing cancers induced or mediated by the two enzymes. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase positive and telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing TERT and L1RT are also disclosed.

Provided is a deoxyribonuclease comprising: (a) an amino acid sequence having at least 85% sequence identity with the sequence of a eukaryotic DNase I; and (b) an amino acid sequence capable of binding nucleic acid non-specifically comprising at least one helix-hairpin-helix motif.

The subject invention provides novel compounds for treatment of cardiac arrhythmia and methods of use.

16α,17α-Epoxy-10β-hydroxyestr-4-en-3-one is useful in the treatment of migraine by nasal administration.