The present invention discloses a multi-sensing information fusion-based power transformer on-line monitoring system and method. With the system and method adopted, online and real-time monitoring of a power transformer can be realized reliably, and vibration, current, voltage and switching quantity information can be acquired, processed, transmitted and analyzed reliably. The multi-sensing information fusion-based power transformer on-line monitoring system of the invention comprises a multi-sensor acquisition assembly; the multi-sensor acquisition assembly includes an acceleration sensor, a voltage sensor, a current sensor, a temperature sensor and a switching quantity acquisition sensor which are respectively used for acquiring the vibration information, voltage information, current information, temperature information and switching quantity information of the power transformer; an embedded master controller is an ARM embedded system-based master controller; a remote controller is a host computer; and the host computer uses SQL Server database software to carry out open database management.