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Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues

InactiveUS20040058415A1High yieldRapid and predictable approachFungiBacteriaDihydrofolic acidAminoacid analog
Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallyglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.
Owner:CALIFORNIA INST OF TECH

System and method for adaptively accommodating a high amplitude downstream signal in a DSL modem

A system and method are disclosed for adaptively accommodating a high amplitude downstream signal in a DSL modem. High amplitude downstream signals are common with local loop lengths of less than about 6,000 feet and can saturate DSL modem components and impair DSL service if not effectively accommodated.In general, a DSL system detects a high amplitude downstream DSL signal and adjusts a DSL modem analog front end in response to the detected high amplitude downstream DSL signal so that analog front end components of a DSL modem are not saturated by the high amplitude downstream DSL signal. Pursuant to one embodiment, a digital signal processor detects the high amplitude DSL signal and, in response, decreases a gain of a first stage receiver to accommodate the high amplitude downstream DSL signal. Another embodiment introduces additional attenuation of the downstream DSL signal to attenuate high amplitude downstream DSL signals before they enter first stage receiver amplifier circuits.
Owner:AVAGO TECH INT SALES PTE LTD

Method for enhanced trans-tissue delivery of therapeutic substances

A method of enhanced trans-tissue delivery of therapeutic substances including; placing an electrode in proximity to human or animal tissue covered with material of sufficient concentration of such substances; applying a voltage signal to generate plasma, preferably Dielectric Barrier Discharge in Air, between the tissue and the electrode.
Owner:DBD INNOVATIONS
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