45results about How to "Low compliance" patented technology

Systems and methods according to the present invention relate to a novel peripheral nerve stimulation system for the treatment of pain, such as pain that exists after amputation.

A method and apparatus for providing low-cost, realistic force feedback including an improved actuator. The invention provides force sensations to a user and includes an interface device coupled to a host computer and allowing a user to interact with a host application program. A user object, such as a joystick, is moveable by a user in at least one rotary degree of freedom. A sensor reports a locative signal to the host computer to indicate a position of the user object. An actuator outputs forces on the user object in response to signals from the host computer and program. The actuator includes a housing, a set of grounded magnets provided on opposing surfaces of the housing and creating a magnetic field, and a rotor coupled to the user object positioned between the magnets. The rotor rotates about an axis of rotation and includes a shaft and teeth spaced around the shaft. An electric current flows through one or more coils on the teeth to cause the rotor to rotate. The teeth and the magnets are provided in a skewed, helical arrangement relative to each other so that, as the rotor rotates, a first tooth gradually exits the magnetic field as the next consecutive tooth gradually enters the magnetic field, thereby significantly reducing a cogging effect of the rotor when the user object is moved by the user and increasing the fidelity of forces experienced by the user.

A balloon catheter having a multi-layered balloon which has a first layer and at least a second layer, and which has noncompliant limited radial expansion beyond the nominal diameter of the balloon. By selecting the polymeric materials forming the balloon layers, and arranging and radially expanding the multiple layers of the balloon in accordance with the invention, a balloon is provided having an improved low compliance, preferably in combination with high flexibility and softness.

An expandable medical device or component thereof including a tubular body formed of a wrapped sheet of porous polymeric material fused together, the tubular body having a fused seam at an angle relative to the longitudinal axis of the tubular body which changes along the length of the tubular body from a first angle to a second angle greater than the first angle. The sheet of porous polymeric material is wound and then fused together such that the winding angle is less in a first longitudinal section of the tubular body compared with the winding angle in a second longitudinal section of the tubular body, in order to provide the second section with greater resistance to expansion (i.e., lower compliance) than the first section.

A balloon catheter having a balloon formed at least in part of a blend of a first polymeric material having a first Shore durometer hardness, and at least a second polymeric material having a second Shore durometer hardness less than the Shore durometer hardness of the first polymeric material. The balloon of the invention has enhanced softness and flexibility due to the presence of the second polymeric material, and a lower than expected compliance. In a presently preferred embodiment, the balloon is formed of a blend of polymeric materials comprising polyether block amides.

Systems and methods according to the present invention relate to a novel peripheral nerve stimulation system for the treatment of pain, such as pain that exists after amputation.

The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.

The problem of the invention is to provide a drug-containing patch which is very favorable in percutaneous absorbability and is excellent in sustainability of the drug efficacy, that is, the drug-containing patch having a sufficient percutaneous absorbability and effect sustainability in a degree to be actually used for therapy of patients. The problem is solved by a patch comprising a drug, a melting point lowering agent and an adhesive base.

Balloon catheter comprises a shaft having a proximal end, a distal end, and an inflation lumen extending therein, and a balloon on the shaft which has an interior in fluid communication with the inflation lumen. The balloon is formed of a blend of polymeric materials comprising a transparent amorphous nylon having a Shore D duromcter hardness of not less than 77D and being not more than about 40% by weight of the blend, and a polyamide or a polyether block amide having a Shore D duromcter hardness of no more than 73D. An increase in radial diameter of the balloon above nominal pressure for one atmosphere of pressure is no greater than 0.025 mm / atm. A guidewire catheter is also provided.

The present invention relates to a device, system and method for monitoring of peripheral arterial perfusion of a subject. To enable distinguishing between low pulsatility caused by centralization or low cardiac output, the proposed device comprises an input (30) for receiving first detection data of a tissue region of a subject, said first detection data being acquired over time by detecting radiation reflected from and / or transmitted through tissue of the subject, and for receiving second detection data of a skin region of subject, said second detection data being acquired over time by detecting radiation received from said tissue region in response to coherent light being emitted towards said skin region, a PPG unit (32) for deriving a photoplethysmography, PPG, signal from said first detection data, a flow unit (34) for deriving, from said second detection data, a flow signal indicative of a flow of light scattering particles within the skin region, and an evaluation unit (36) for evaluating said PPG signal and said flow signal to obtain information on the peripheral arterial perfusion, wherein the evaluation unit is adapted to determine a state of low vascular compliance and / or a state of low cardiac output based on a combined evaluation of said PPG signal and said flow signal.

In various embodiments, aspiration tubing connecting a handpiece to a surgical console may include a high compliant section, a transition section, and a low compliant section. In some embodiments, the high compliant section may have a lower durometer and / or different geometry than the low compliant section. The transition section may take a number of forms, including a connector or a continuous section of tubing that gradually increases in durometer and / or changes geometry through the length of the tubing. In the various embodiments, the high compliant section may provide flexibility near the handpiece to make the handpiece easier to hold and maneuver while the low compliant section may reduce the effects of occlusion break surge. In some embodiments, the high compliant section may include, for example, ribs, stiffening rings, a stiffening sleeve, or a stiffening sock to increase the stiffness of the high compliant section.

The present invention refers to medical devices. Particularly it relates to stent devices and balloon catheter devices. In the most particular aspect of the invention it relates to balloon catheter devices carrying stents (2) with the medical balloon (3) comprising an inner layer (4) having a lower compliance rate and / or burst pressure than the outer layer (5) and an outer layer (5) having on the outer surface (6a) a higher adhesion strength than the inner layer (4), and its use in a variety of medical procedures to treat medical conditions in animal and human patients.

The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.

A method of treating cholesterol imbalance, high LDLs, and other metabolic syndrome problems and symptoms of osteoarthritis. The regimen preferred embodiment includes lipids as 60% or more of daily caloric content, protein up to 10%-15% of daily caloric content; and carbohydrates up to 25% or less of daily caloric content, primarily in the form of non-starchy, low-glycemic fresh fruit and vegetables, and nuts, along with a daily intake of 35 grams of dietary fiber, with a significant percentage of this as soluble fiber; average daily cholesterol intake of less than 10 mg, and 30 grams of cocoa solids.

A balloon catheter assembly includes a catheter shaft, and a balloon mounted on the catheter shaft. The balloon includes a distal neck portion, a proximal neck portion, and an inflatable body portion in between the distal and proximal neck portions. The distal and proximal neck portions are connected to the catheter shaft. The balloon also includes a fiber provided on the body portion. The fiber is oriented relative to the longitudinal axis of the body portion at an angle between about 45° and about 135°, and has a diameter of less than about 10 μm.

In various embodiments, aspiration tubing connecting a handpiece to a surgical console may include a high compliant section, a transition section, and a low compliant section. In some embodiments, the high compliant section may have a lower durometer and / or different geometry than the low compliant section. The transition section may take a number of forms, including a connector or a continuous section of tubing that gradually increases in durometer and / or changes geometry through the length of the tubing. In the various embodiments, the high compliant section may provide flexibility near the handpiece to make the handpiece easier to hold and maneuver while the low compliant section may reduce the effects of occlusion break surge. In some embodiments, the high compliant section may include, for example, ribs, stiffening rings, a stiffening sleeve, or a stiffening sock to increase the stiffness of the high compliant section.

Twin bore ophthalmologic tubing includes first and second tubes. The second tube has portions of differing hardness with one of the portions being at an end of that tube. The second tube has a portion at its other end with about the same hardness. Portions of the first and the second tubes may have about the same hardness. In some embodiments, portions of the first and second tubes with the same hardness can correspond to each other along the tubing. One of the portions can have a hardness of 80 to 90 shore A while the other portion can be 60 to 70 shore A. In some embodiments, portions with 60 to 70 shore A hardness can be about six to twelve inches long.

A combination of urethane polymeric components provides desired characteristics in forming medical instruments such as catheters and balloons for dilatation catheters. For example, a balloon material is formed form a blend of urethane polymeric components, including a first polymeric component having a first glass transition temperature and a second polymeric component having a second glass transition temperature. The first polymeric component can be branched or straight chain of thermoplastic polyurethane compound having a glass transition temperature polyurethane compound having a glass transition temperature higher than normal human body temperature. The second polymeric component can be a second thermoplastic polyurethane having a glass transition temperature equal to or lower than normal human body temperature. The polymeric blend can be heat treated to further enhance the properties or stability of the balloon material, including significantly increasing burst pressure.

The systems and methods described herein relate to an improved stretchable hose apparatus which enables the transmission of high-throughput signals along several conductors within a conductor cable. In particular, the stretchable hose enables consistent high speed communications and high power transmission between a buoyant object and an optional underwater device in all weather conditions by permitting compression of the conductor cable in a first range of hose extensions and limiting elastic elongation of the conductor cable in a second greater range up to full hose extension.

An expandable medical device or component thereof including a tubular body formed of a wrapped sheet of porous polymeric material fused together, the tubular body having a fused seam at an angle relative to the longitudinal axis of the tubular body which changes along the length of the tubular body from a first angle to a second angle greater than the first angle. The sheet of porous polymeric material is wound and then fused together such that the winding angle is less in a first longitudinal section of the tubular body compared with the winding angle in a second longitudinal section of the tubular body, in order to provide the second section with greater resistance to expansion (i.e., lower compliance) than the first section.

combination of at least two polyamides. The catheter component can be made from a blend of the two polyamides, or a co-extrusion of the two polyamides with an inner layer and an outer layer. The first polyamide has a Shore D durometer hardness of more than seventy seven (77), and can be selected from various transparent amorphous nylons having an amorphous segment such as an aliphatic segment, an aromatic segment, or a cycloaliphatic segment. The second polyamide has a lower durometer hardness than the first polyamide, and preferably less than 73, and can be a block copolymer of nylon and polytetramethylene glycol. Both polyamides have the same amide block or segment, e.g. nylon 12. Adding small amounts of the high hardness polyamide can reinforce the low polyamide at the amorphous segments, thereby increasing the overall strength of the material.

The present invention is directed to an injection molding valve configured to prevent the leaking or stringing of injected thermoplastic from the valve. The valve includes a housing having a first bore along a length thereof and a second bore intersecting the first bore. A rotatable member is inserted through the second bore and is in communication with a lever for the actuation thereof. The rotatable member includes a hole therethrough such that when the hole is aligned with the first bore, thermoplastic may travel freely through the first bore. The second bore further includes at least one groove in communication with a port for receiving injected thermoplastic. The injected thermoplastic is hardened to form an seal therein and configured to prevent thermoplastic from leaking out of the valve housing.

The invention discloses an orally taken granule for treating malaria and a preparation method thereof. The orally taken granule contains artesunate, coating material, stabilizer, filler, preservative and corrigent. 1000mg of oral liquid contains 60g of artesunate, 5g of coating material, 0.35g of stabilizer, 550g of filler, 1.2g of preservative and 5g of corrigent. The orally taken granule can overcome the shortage of infant medicines and can meet the requirement of infant for taste; plenty of documents and practices prove that the medicinal saccharose is taken as main filler, and meanwhile, the covering function of different coating materials for the bitter and the guiding functions of acesulfame and natural plant essence for gustation are surveyed, and the optimal tasty formula is screened through plenty of blinding data model researches.

In accordance with the invention, a low impedance surface-mount connector comprises a length of cylindrical rod having an I-shaped cross section. The device permits interconnection by pick-and-place techniques, and the interconnection has advantageous qualities of low resistance, low inductance, mechanical compliance and ease of manufacture. A first circuit device having one or more circuit components is interconnected with a second circuit device by surface mounting such connectors on the first circuit device, providing corresponding solder pads on the second circuit device, and mounting the connectors of the first circuit device onto the pads of the second.

Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.