The invention provides a network information diffusion source inference method based on a differential pre-solution set and belongs to information technology processing field. The method comprises steps of using G = (V, E) to represent a connection relationship between the network nodes, wherein V represents a network node set, e represents a set of network edges; selecting a difference pre-solution set S from the difference pre-solution sets; establishing diffusion source characteristics, collecting cascading information, judging the module | Ic | of an index set, if the module | Ic | is greater than a preset value, extracting a characteristic vector of cascading C, adjusting the diffusion source characteristics of each node v belonging to V, calculating norms of all nodes v belonging toV one by one, and finding out the node with the minimum norm as a source. According to the method, the data source can be actively optimized and selected, the quality of input data is improved, and the source inference precision is greatly improved.