The invention relates to an automatic production line of a fuel cell stack. The automatic production line comprises a material taking and placing region, a stack lamination fastening region, a primaryperformance test region, an artificial assembly region, an artificial rework region, a part installation region, a secondary performance test region, a product off-line region, a manipulator and a control server, wherein the manipulator comprises a first manipulator, a second manipulator, a third manipulator, a fourth manipulator and a fifth manipulator, and the manipulators can slide along respective rails in a reciprocating way to take and place materials. In the automatic production line, a large part of production operation is completed by a mechanical program, high automation is achieved, modular and large-scale production of a fuel cell is easy to achieve, the continuity of production links is maintained, the production efficiency is substantially improved, the production cost is reduced, the automatic production line is suitable for producing different specifications of cell panels, is wide in application range and is flexible and simple to adjust, each production equipment isindependent, the production line is compact in layout, high in design flexibility, and compatibility, upgrading and transformation are easily achieved.