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33results about How to "Improve escape ability" patented technology
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Gene vector system, its preparation and application
ActiveCN102899343ADoes not affect compounding abilityImprove binding efficiencyGenetic material ingredientsRespiratory disorderIntracellularGenetic Materials
The invention discloses a gene vector system of a redox sensitive shielding system having targeting function, its preparation and application in the field of gene therapy. The gene vector system disclosed herein comprises a redox sensitive shielding system having targeting function, a cationic high-molecular material and plasmid DNA; wherein the cationic high-molecular material and plasmid DNA form compound particles, the redox sensitive shielding system having targeting function shields the compound surface by electrostatic action, thus the toxicity of the vector can be reduced, the loaded genetic material is transferred into the cell successfully, the expression of the genetic material is realized, the transfection process is completed, the targeting of gene transfection can be raised, and simultaneously the gene transfection efficiency is raised.
Owner:SICHUAN UNIV
Smart teaching management method applied to campus
The invention relates to the field of campus management and provides a smart teaching management method applied to a campus to solve the technical problem that it is difficult for students to view information disclosed in a school server when the students are at school. The method comprises the steps that S1, a school inputs student management information and teaching information into the school server, the school server stores the student management information and the teaching information, and the school server is in signal connection with a cloud control center; S2, a teacher terminal acquires the student management information and the teaching information in the school server, and a parent terminal acquires the corresponding student management information and teaching information in the school server; and S3, a class terminal accesses the school server, wherein the class terminal sends self-identity information when accessing the school server, the school server determines the identity of the class terminal according to the identity information, and the school server sends the teaching information relevant to the class terminal according to the identity of the class terminal.
Owner:重庆大争科技有限公司
Engineered immune effector cells and use thereof
PendingCN111954715AIncrease resistanceImprove permeabilityAntibody mimetics/scaffoldsStable introduction of DNAAntiendomysial antibodiesGenome editing
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
Owner:FATE THERAPEUTICS
Star-shaped multi-targeting functional gene vector based on POSS and application
ActiveCN108531513AEnhanced ability to load genesSmall particle sizePolypeptide with localisation/targeting motifOther foreign material introduction processesGene deliveryMethacrylate
The invention discloses a star-shaped multi-targeting functional gene vector based on POSS and application. A preparation method of the vector includes: allowing octaamino POSS and 2-bromoisobutyryl bromide to have reaction to generate macroinitiator POSS-(Br)n, performing two-step atom transfer polymerization reaction to graft hydrophilic dimethylaminoethyl methacrylate and poly(ethylene glycol)methacrylate to the POSS, introducing double bonds to the tail end of polymer, and modifying targeting functional polypeptide to the polymer to obtain the star-shaped multi-targeting functional gene vector based on POSS. A gene delivery system can be prepared by using the star-shaped multi-targeting functional gene vector based on POSS. The star-shaped multi-targeting functional gene vector based on POSS has the advantages that the star-shaped gene vector allows positive charges to be concentrated, so that the gene carrying ability of the polymer is enhanced; stable micelles small in particle size can be formed easily, and cell uptake is benefited; the PDMAEMA chain segment is used as the main chain segment for carrying the compressed gene, so that endosome escaping ability can be enhanced.
Owner:TIANJIN UNIV
Multi-targeted modified gene-loaded compound, preparation method and application
InactiveCN106086079AIncrease intakeImprove escape abilityGenetic material ingredientsOther foreign material introduction processesChemistryNucleic acid
The invention discloses a multi-targeted modified gene-loaded compound, a preparation method and application. The method comprises the following steps: preparing a membrane targeted peptide modified polycation gene vector (I); evenly mixing a TAT-NLS polypeptide aqueous solution and a nucleic acid aqueous solution to obtain mixed liquor, and preparing the gene vector (I) into suspension liquid; and (4) evenly mixing the suspension liquid and the mixed liquor, and standing to obtain the multi-targeted modified gene-loaded compound. The multi-targeted modified gene-loaded compound is specifically recognized by REDV peptide in membrane targeted peptide and an integrin receptor on the surface of an endothelial cell, and uptake of the cell to the compound is improved. The compound which enters the cell is positioned in a lysosome / endosome structure, polyethyleneimine and TAT jointly act, the escaping capacity of the endosome of the compound is improved, and a target gene is promoted to enter cytoplasm. Through interaction of a nuclear localization signal NLS and a nuclear membrane, nuclear internalization of the target gene is promoted. Transfection efficiency of the target gene in the endothelial cells is high.
Owner:TIANJIN UNIV
Automobile inflowing escaping system and method
InactiveCN105346493APrevent water ingressProtection securityPedestrian/occupant safety arrangementElectronic controllerWater level
The invention discloses an automobile inflowing escaping system. The automobile inflowing escaping system comprises a water level sensor, an electronic controller and an air bag assembly. The electronic controller is connected with the water level sensor. The electronic controller is connected with and controls the air bag assembly. The air bag assembly comprises air bags, gas generators and an igniter. The igniter is connected with the gas generators. The gas generators are connected with the air bags. The air bags comprise the first air bags arranged at the front end, the rear end and the two sides of an automobile chassis. The water level sensor is arranged on the chassis, the inflowing water level detection of an automobile can be carried out at any time, and water level information is sent to the electronic controller. When the water level exceeds the automobile body safety depth, the electronic controller initiatively triggers the igniter and the gas generators to inflate the air bags, the function of preventing inflowing of the automobile is achieved, the automobile can float on the water surface accordingly for escaping, trouble and labor are saved, losses are reduced, and personal safety is protected.
Owner:FJ MOTOR GRP YUDO NEW ENERGY AUTOMOBILE CO LTD
Multi-type harvester cooperative scheduling optimization method based on improved whale algorithm
PendingCN110070212AImprove escape abilityIncrease diversityForecastingArtificial lifeLocal optimumSelf adaptive
The invention discloses a multi-type harvester cooperative scheduling optimization method based on an improved whale algorithm, and belongs to the technical field of agricultural mechanical equipmentresource optimization configuration. The key points of the technical scheme are as follows: a convergence factor adaptive change strategy is introduced, and non-elite individual historical informationcompletely participates in the variation strategy; that is to say, through self-adaptive change of the convergence factor, the algorithm can keep a relatively strong global exploration capability anda relatively fast convergence speed at a relatively large step length in the early evolution stage, and perform deep development at a relatively small step length in the later evolution stage, so that the quality of a solution is improved; all historical parent individual information of continuous 10 generations of non-evolved individuals participates in a mutation strategy, and the historical information of the individuals participates in mutation, so that the diversity of populations can be quickly improved, and the algorithm jumps out of local optimum. The working efficiency of the harvester is effectively improved, a good reference is provided for intelligent dispatching of the harvester, and meanwhile further development of agricultural intelligent equipment is promoted.
Owner:HENAN INST OF SCI & TECH
Backpack type personal high-rise escape device
The invention provides a backpack type personal high-rise escape device. The backpack type personal high-rise escape device is characterized in that the personal high-rise escape device is arranged in a backpack; two waistband earrings are arranged on the left side and the right side of a rear shell of the personal high-rise escape device correspondingly, each waistband earring is connected with the rear shell, and a waistband is fixed to or penetrates the waistband earrings; two waistband holes are formed in the left side and the right side of the backpack correspondingly, and the left end portion and the right end portion of the waistband penetrate the waistband hole in the same side; and a steel wire rope hole is further formed in the upper portion of the backpack, and the outer end of the steel wire rope of the personal high-rise escape device is tied to a hook after penetrating the steel wire rope hole, in other words, the hook is arranged outside the backpack. The backpack type personnel high-rise escape device has the beneficial effects that a transmission mechanism of the personal high-rise escape device is in an airtight state, other impurities can be prevented from entering the transmission mechanism, and the escape reliability is obviously improved; and in addition, an auxiliary device of the escape device can be assembled on the escape device, and the escape effect is improved.
Owner:中裹安全应急科技集团有限公司
Improved multistage dual cyclone dust and mist eliminator
ActiveCN105396409AContinuous and uniform liquid filmReduce droplet escapeCombination devicesWater pipeFlue gas
Belonging to the technical field of flue gas purification, the invention in particular relates to an improved multistage dual cyclone dust and mist eliminator, which includes a plurality of dual cyclone devices. Each dual cyclone device comprises an inner cyclone cylinder, the inner cyclone cylinder is internally provided with a blind cylinder, the blind cylinder is internally provided with a flushing water pipe, the inner cyclone cylinder is externally provided with outer cyclone blades, the blind cylinder is externally provided with inner cyclone blades, the plurality of dual cyclone devices are multistage dual cyclone devices connected in series vertically, the inner surface of the outer cyclone cylinder is provided with first mist drop escape proof devices over each dual cyclone device, and the upper part of the inner cyclone cylinder inner surface is equipped with a second mist drop escape proof device. The first mist drop escape proof devices and the second mist drop escape proof device are all in the shape of a conical ring with big top and small bottom. The conical ring shaped mist drop escape proof devices are convenient for formation of liquid films in the cyclone cylinders, thus reducing mist drop escape and improving the dust removal effect.
Owner:BEIJING ZHONGNENG NUOTAI ENERGY SAVING & ENVIRONMENTAL PROTECTION CO LTD
Glass lifer and vehicle with same
ActiveCN105909113AImprove escape abilityMeet the needs of different passengersPower-operated mechanismPeep-holesGear wheelEngineering
The invention discloses a glass lifer and a vehicle with the same. The glass lifter comprises an electric motor, a hand-cranking device, a planetary gear mechanism, a lifting driving assembly and a switching device; a planet gear is arranged on a planet carrier and meshes between a sun gear and a gear ring; two of the sun gear, the planet carrier and the gear ring respectively serve as a first input end and a second input end and the remaining one serves as an output end; the first input end is connected with the electric motor; the second input end is connected with the hand -cranking device; the lifting driving assembly is connected with the output end and glass so as to drive glass to rise and fall; and the switching device is arranged for unlocking or locking the hand-cranking device so as to realize power input switching between the electric motor and the hand-cranking device. Therefore, vehicle door glass can be provided with two driving modes of electric driving and hand cranking; and in a dangerous state, a driver and passengers can open vehicle windows by the hand-cranking device to escape, thereby improving the escaping capabilities of the driver and the passengers.
Owner:BAIC MOTOR CORP LTD
Folding high-rise escape ladder
InactiveCN102305019AImprove escape abilityThe role of the high-rise escape ladder is the greater effect of escapeLaddersEngineeringHigh rise
The invention relates to a folding high-rise escape ladder comprising a hook (1), steps (2), a hinge (3), a protective casing (4) and subsections (5), wherein heads and tails of the subsections are fixedly connected through the hinge (3); the hook (1) is fixed at the upper end of one subsection (5) at the uppermost part; the steps (2) are arranged on each subsection (5); the protective casing (4) is sleeved on the pipe wall above the hinge (3). The folding high-rise escape ladder provided by the invention can be used for rapid escape in first time at the early period of a fire; especially under the circumstance that elevators cannot be used, firefighting accesses and fire ladders are full of smoke, whole building passageways is full of people everywhere and the fire ladders cannot be normally used, the effect of the high-rise escape ladder provided by the invention can be better shown.
Owner:DONGHUA UNIV
CAGW polypeptide and TAT-NLS polypeptide-modified gene-loaded composite, preparation method and application thereof
ActiveCN109701034AGood compatibilityImprove escape abilityGenetic material ingredientsGene therapyOrganic chemistryPolyethylenimine
The invention relates to a CAGW polypeptide and TAT-NLS polypeptide-modified gene-loaded composite, a preparation method and an application thereof. The preparation method comprises the following steps: preparing polyethylene glycol-PGLA copolymer mPEG-b-PLGA; preparing a PGLA-g-polyethyleneimine copolymer PLGA-g-PEI; using PLGA-g-PEI as a raw material for preparation of a PLGA-g-PEI-g-CAGW copolymer; performing self-assembly preparing on the targeted copolymer micelles by of PLGA-g-PEI-g-CAGW and mPEG-b-PLGA; adding pDNA and TAT-NLS to the targeted copolymer micelles to prepare the gene-loaded composite. The gene-loaded composite prepared by the invention has specific selectivity to cells, has good penetrating ability and nuclear importing ability, and has high transfection efficiency.
Owner:QINGHAI UNIV FOR NATITIES +1
Genetic vector system of nanoparticle with multiple oxidation-reduction stimulus response as well as preparation method and application of genetic vector system
ActiveCN103305549BExcellent gene transfection efficiencyEscape clearanceGenetic material ingredientsRespiratory disorderTernary complexVector system
The invention discloses a genetic vector system of a nanoparticle with multiple oxidation-reduction stimulus response as well as a preparation method and application of the genetic vector system. The genetic vector system is composed of a shielding system, a cation material and foreign plasmid DNA (deoxyribonucleic acid); and the shielding system and the cation material both have oxidation-reduction stimulus response, so that a ternary complex nanoparticle with multiple oxidation-reduction stimulus response is formed. The genetic vector of the ternary complex nanoparticle is low in cytotoxicity, and capable of well compressing and compounding the plasmid DNA under physiological conditions, successfully transferring a supported genetic substance into a cell and entering the cell; and the reduction environment in the cell can be more rapidly broken to release the supported gene, so that the expression of gene substances is realized, the transfection process is finished, and the gene transfection efficiency can be remarkably increased.
Owner:SICHUAN UNIV
Ocean platform with escape device
ActiveCN112896459AImprove sealingImprove the escape effectLife-savingFloating buildingsElectric machineryEngineering
Owner:于丽萍
Poss-based star-shaped multiple targeting functional gene carrier and its application
ActiveCN108531513BEnhanced ability to load genesSmall particle sizePolypeptide with localisation/targeting motifOther foreign material introduction processesMethacrylateGene delivery
The invention discloses a star-shaped multi-targeting functional gene carrier based on POSS and its application. The carrier is made by the following method: octaamino POSS reacts with 2-bromoisobutyryl bromide to generate a macromolecular initiator POSS-(Br )n, through two-step atom transfer polymerization, the hydrophilic dimethylaminoethyl methacrylate and poly(ethylene glycol) methacrylate are grafted on POSS, and double bonds are introduced at the end of the polymer, and finally , modify the targeting functional polypeptide to the polymer to obtain a star-shaped multi-targeting functional gene carrier based on POSS, which can be used to prepare a gene delivery system. The star-shaped structure of the gene carrier of the present invention can make the positive charge more Concentration, thereby enhancing the ability of the polymer to load genes; it is easier to form stable micelles with smaller particle sizes, which is more conducive to cell uptake. Using the PDMAEMA chain segment as the main chain segment to load the compression gene can enhance the endosome escape ability.
Owner:TIANJIN UNIV
Augmented reality stereoscopic display method and system for fire drills
ActiveCN111105660BImprove COPImprove escape abilityCosmonautic condition simulationsSteroscopic systemsEngineeringEnvironmental simulation
The present invention proposes an augmented reality three-dimensional display method for fire drills, comprising the following steps: S1, obtaining character feature information of personnel; S2, encapsulating the character feature information into character feature quantities; S3, converting the character feature quantities Input to the fire simulation server to obtain the environment simulation information; S4, input the character feature quantity and the environment simulation information to the fire simulation server to obtain the person state simulation information; S5, the photographer visually observes the scene picture; S6, the environment simulation information and the personnel The state simulation information is combined with the visual scene picture to obtain a display picture superimposed with the dynamic picture of the environment simulation and the dynamic picture of the personnel status. Let the personnel conducting the fire drill be personally on the scene, and make corresponding treatment according to the displayed fire picture and the prompted physical state, which can ensure more effective and full play of the effect of the fire drill, and improve the face of the personnel participating in the fire drill. Ability to deal with fire and escape ability.
Owner:重庆特斯联智慧科技股份有限公司
Intelligent sound and light guide evacuation system
PendingCN108022387AImprove escape abilityShort escape timeSignalling system detailsElectric transmission signalling systemsLight guideLoudspeaker
The invention relates to an intelligent sound and light guide evacuation system, which comprises a main controller. The main controller is connected with at least one group of regional broadcast controller and at least one group of light guide controller. The regional broadcast controller is at least connected with one group of independent loudspeaker. The light guide controller is at least connected with one group of light band. The main controller is used for receiving a disaster source alarm linkage signal and sending the disaster source alarm linkage signal to the regional broadcast controller and the light guide controller. The independent loudspeaker is used for playing broadcast content transmitted by the regional broadcast controller. The light band is used for displaying light guide evacuation mode transmitted by the light guide controller. The intelligent sound and light guide evacuation system can provide a correct evacuation scheme for people according to the disaster occurrence place, achieves an effect of combination of sound guidance and light guide vision, allows escape personnel to clearly hear the escape mode from the broadcast, effectively enables the escape personnel to escape away from the dangerous area based on continuity of light guide vision, reduces disaster rescue time and can effectively prevent casualty of people due to wrong escape.
Owner:上海浩毅安防科技有限公司
Gene-carrying compound for multiple targeting modification, preparation method and application
InactiveCN106086079BIncrease intakeImprove escape abilityGenetic material ingredientsOther foreign material introduction processesNuclear membraneLysosome
The invention discloses a multi-targeted modified gene-loaded compound, a preparation method and application. The method comprises the following steps: preparing a membrane targeted peptide modified polycation gene vector (I); evenly mixing a TAT-NLS polypeptide aqueous solution and a nucleic acid aqueous solution to obtain mixed liquor, and preparing the gene vector (I) into suspension liquid; and (4) evenly mixing the suspension liquid and the mixed liquor, and standing to obtain the multi-targeted modified gene-loaded compound. The multi-targeted modified gene-loaded compound is specifically recognized by REDV peptide in membrane targeted peptide and an integrin receptor on the surface of an endothelial cell, and uptake of the cell to the compound is improved. The compound which enters the cell is positioned in a lysosome / endosome structure, polyethyleneimine and TAT jointly act, the escaping capacity of the endosome of the compound is improved, and a target gene is promoted to enter cytoplasm. Through interaction of a nuclear localization signal NLS and a nuclear membrane, nuclear internalization of the target gene is promoted. Transfection efficiency of the target gene in the endothelial cells is high.
Owner:TIANJIN UNIV
Amino lipid as well as preparation method and application thereof
ActiveCN114874107AAtom economy is highIncrease carrying capacityOrganic active ingredientsOrganic compound preparationLysosomeCytotoxicity
The invention belongs to the technical field of medical chemistry, and particularly relates to amino lipid as well as a preparation method and application thereof, the ionizable amino lipid as shown in a formula (I) or pharmaceutically available salt thereof disclosed by the invention is mild in reaction condition, free of protection and deprotection and high in atom economy in the process of constructing the amino lipid. In in vitro and in vivo delivery studies, excellent ability to deliver nucleic acids into cells is shown. The amino lipid compound has a plurality of degradable groups, the introduction of the groups not only improves the entrapment capacity of nucleic acid, but also significantly enhances the escape capacity of nucleic acid in endosome / lysosome, and can also contribute to release of delivery targets such as target drugs or genes while greatly reducing the cytotoxicity, thereby improving the delivery efficiency. The preparation method of the amino lipid compound has the advantages of easily available raw materials, mild reaction conditions, good reaction selectivity, high reaction yield, low requirements on instruments and equipment and simplicity in operation.
Owner:SHENZHEN MAGICRNA BIOTECHNOLOGY CO LTD
A degradable miRNAs-loaded nanocomposite coating and its preparation method and application
ActiveCN110237312BImprove securityImprove effectivenessSurgeryPharmaceutical delivery mechanismSmooth muscleControlled release
The invention relates to a degradable nanocomposite coating loaded with miRNAs, a preparation method and application thereof. The construction method includes the following steps: S1: construction of miRNAs-loaded nanoparticles; S2: modification of miRNAs-loaded nanoparticles; S3: deposition and thiolation of polydopamine coating; S4: miRNAs-loaded nanoparticles / hyaluronic acid hydrogel Preparation of adhesive composite coatings. Through the construction of the coating, the invention can realize the controlled release and intracellular delivery of miRNAs-loaded nanoparticles, selectively inhibit blood coagulation reaction and excessive proliferation of smooth muscle, promote the growth of endothelial cells, and effectively improve the biocompatibility of materials.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
Gene vector system, its preparation and application
ActiveCN102899343BDoes not affect compounding abilityImprove binding efficiencyGenetic material ingredientsRespiratory disorderIntracellularGenetic Materials
Owner:SICHUAN UNIV
Targeted chitosan cross-linked gel and its preparation method and application
ActiveCN112006979BGood pH buffering capacityHas CD44 targeting functionAerosol deliveryOintment deliveryCombinatorial chemistryPharmaceutical Aids
The invention provides a kind of chitosan cross-linked gel and its preparation method and application, the method utilizes chitosan and imidazole-4,5-dicarboxylate dimethyl to prepare imidazole cross-linked chitosan, and adopts Coated with hyaluronic acid, the gel has strong proton buffering capacity and drug loading function, and has CD44 targeting, which can be used as drug excipients and has broad application prospects.
Owner:DALIAN NATIONALITIES UNIVERSITY
Lipid nanoparticles and use thereof in nucleic acid delivery
ActiveCN114539083ALow membrane fusionImprove securityEsterified saccharide compoundsSugar derivativesViral vectorTumor cells
The invention discloses lipid nanoparticles and application thereof in nucleic acid delivery. The functional lipid provided by the invention takes tertiary amine or a PEG fragment as a hydrophilic part, amino acid as a skeleton, an ester bond as a connecting bond and an alkane chain as a hydrophobic part, and has the advantages of good biocompatibility, high safety, simple and rapid synthesis method and the like. The lipid nanoparticles prepared based on the functional lipid designed by the invention can stably load nucleic acid drugs, and the transfection effect on primary cells and tumor cells is remarkable. The invention provides a novel lipid material capable of effectively transfecting cells, and provides a safe and effective non-viral vector platform for cell transfection.
Owner:CHINA PHARM UNIV
Window regulator and vehicle having same
ActiveCN105909113BPromote escapeImprove escape abilityPower-operated mechanismPeep-holesGear wheelEngineering
Owner:BAIC MOTOR CORP LTD
Backpack-style personal high-rise escape device
Owner:中裹安全应急科技集团有限公司
A vehicle door opening assist device and its control method
ActiveCN104533209BImprove securityEasy to leavePower-operated mechanismElectrical locking circuitsVehicle frameComputer module
The invention relates to the technical field of safety of vehicles, and provides a door opening assisting device for a vehicle and a control method of the device. The device comprises a pressure sensor, a door switching determining module, a control module and at least one pair of magnetic elements; two magnetic elements in each pair of magnetic elements are respectively oppositely arranged on a door and a vehicle frame; the door switching detecting module is used for detecting the state of the handle on the door and sends an opening signal to the control module when detecting that the door handle is pulled; the pressure sensor is used for detecting the water pressure value borne by the door and sends the water pressure value to the control module; when determining that the water pressure value is more than the preset value and the opening signal is received synchronously, the control module controls the two magnetic elements of each pair of magnetic elements to generate interaction repulsive to assist to open the door. According to the device, the control module controls the magnetic elements to produce a magnetic field which assists to open the door, and therefore, a user can easily pull and open the door in case of falling into deep water, and as a result, the escape capacity of the user is improved, and the safety performance of the vehicle is improved.
Owner:SHENZHEN HUABAO ELECTRONICS TECH
Tunnel safety warning lifting system based on coating mode and coating method of mark coating of tunnel safety warning lifting system
ActiveCN113356103AWide adaptabilityEasy to implementTraffic signalsRoads maintainenceStructural engineeringMechanical engineering
The invention provides a tunnel safety warning lifting system based on a coating mode and a coating method of the mark coating of the tunnel safety warning lifting system. Safety warning marks are designed in the coating mode, the tunnel safety warning lifting system can be suitable for wall face marks of different types, and the tunnel safety warning lifting system has the advantages of being wide in adaptability, easy to implement and maintain and low in cost; the size of the mark coating is determined according to the designed vehicle speed, the remote identification requirement can be met, the warning effect is safely improved, and the safe evacuation and escape effect can be obviously improved.
Owner:CHINA MERCHANTS CHONGQING COMM RES & DESIGN INST +2
Offshore platform with escape device
ActiveCN112896459BImprove sealingImprove escape abilityLife-savingFloating buildingsMarine engineeringElectric machinery
Owner:于丽萍
Ternary complex nano-medicine and its preparation method and its application in the preparation of light-controllable release nano-delivery system
ActiveCN108524946BPromote endocytosisEnhanced nuclear intakeEnergy modified materialsGenetic material ingredientsThioketalLysosome
The invention discloses a ternary complex nanodrug, a preparation method and application thereof in preparation of a light controlled release nano-delivery system. The ternary complex nanodrug comprises a thioketal bond crosslinked low molecular weight PEI-based polymer, a hyaluronic acid polymer attached with a photosensitizer, and a nucleic acid drug. The photosensitizer contained in the complexcan generate reactive oxygen species (ROS) under the control of exogenous red light, realize photochemical internalization (PCI) mediated lysosome escape and photopromoted polymer degradation, thus finally realizing the purposes of reducing the toxic and side effects of materials, improving the transfection efficiency, and enhancing the tumor gene therapeutic effect.
Owner:SUZHOU UNIV
Vehicle wading safety experience method and experience device
PendingCN113192380AImprove self-rescue abilityLearning securityCosmonautic condition simulationsSimulatorsMarine engineeringSafety education
The invention relates to the field of vehicle wading safety experience and particularly relates to a vehicle wading safety experience method and a experience device. The method comprises the following steps that S1, an experiencer enters an experiencing vehicle, external force F is applied to a vehicle door of the experiencing vehicle through external force to enable the vehicle door to be in a closed state, and the external force F is matched with pressure applied to the vehicle by water when the actual vehicle wades into water; S2, an experiencer is prompted to push a vehicle door from the interior of the experiencing vehicle, if the vehicle door is opened, a step S3 is carried out, and otherwise, the experiencer is prompted to enter a window breaking escape link; and S3, the force F is increased, and steps S1 to S2 are repeated till the increased external force F is greater than a threshold value. According to the method, a platform and an environment are provided for traffic wading safety education, and based on the pressure applied to the automobile by water when the automobile wades in a real environment, a practice blank of driving wading education is perfected, and a problem of automobile wading safety education is solved.
Owner:辰安云服技术有限公司 +1
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