The invention provides an OTP-SD electronic publication encryption method; a logic unit of an OTP-SD main control chip is pre-programmed, a storage unit in an OTP-SD card is divided into two parts, i.e. a file system and a non-public storage area, an agreed authentication string is burned in a register of the main control chip, and the access to the non-public storage area is controlled and authenticated; and the data of an electronic publication and a special reader are stored in the file system, and a key is stored in the non-public storage area. Based on the use of a universal SD card interface, a traditional SD card and an encryption method are improved, thereby enhancing the copyright protection function and enabling users and reading terminals to identify; and semi-conductor storageis used for replacing a traditional storage medium so as to publish the electronic publication.