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Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

The present invention provides for diagnostic kits for identifying cancer patients who are more susceptible to cancer therapies employing endostatin and other angiogenesis inhibitors, based upon the discovery that Nucleolin is a specific receptor for Endostatin. In particular, the diagnostic kits include antibody molecules against Nucleolin, DNA or RNA molecules that specifically bind to nucleic acid molecules encoding Nucleolin. The present invention also discloses methods of screening for angiogenesis inhibitors which specifically interact with Nucleolin, and act as angiogenesis inhibitors in an analogous manner as Endostatin. In addition, the present invention discloses methods of inhibiting the proliferation of endothelial cells or angiogenesis of tumor by administering an anti-nucleolin antibody linked to a cytotoxic agent such as tumor necrosis factor alpha to the endothelial cells.

The present invention relates to a method for connecting a metal workpiece and a plastic workpiece by means of a joining tool, including positioning the metal workpiece and the plastic workpiece, bringing the front end of the pin, the sleeve and the clamping ring in contact with an outer surface of the metal workpiece, rotating the sleeve and the pin so as to generate friction between the front ends of the sleeve and the pin and the outer surface of the metal workpiece, and moving the pin and the sleeve in the axial direction while both are rotated, one of the sleeve and the pin penetrating into the metal workpiece and the other of the sleeve and the pin being retracted from the outer surface thereof. The axial movement into the metal workpiece is stopped before the one of the sleeve and the pin reaches the contact surface and after stopping the axial movement the one of the sleeve and the pin is retracted from the metal workpiece and the other is moved towards the outer surface of the metal surface until the front ends of the pin and the sleeve are on the same level.

The present invention generally relates to imaging and selective retention of phospholipid ether analogs in various neoplastic tissues. Specifically, the present invention relates to imaging and methods for selective retention of analogs, for example, NM404, in cancers such as Colorectal Cancer.

A system for positioning a vehicle over a wireless charging station. The system includes a plurality of ultra wideband transceivers (UWBX) installed on the vehicle and the wireless charging station, and a controller configured to determine various distances between the various UWBXs.

A metallic glass-coated wire is formed by drawing a hollow glass fiber from a container in which molten alloy is entrained and solidified. Interference stresses extant between the glass coating and the alloy core of the wire are produced by systematically controlling thickness and mechanical elastic properties of the glass. The interference stress is tailored by selection of glass thickness and chemistry to optimize wire drawing process conditions, such as drawing temperature and strain rate. In addition, the interference stress is especially tailored to assure physical integrity of the glass-alloy composite wire product. Local property variations along the wire length are minimized, facilitating production of discrete wire segments especially suited for use in EAS applications.

The present invention relates to a method for connecting a metal workpiece and a plastic workpiece by means of a joining tool, including positioning the metal workpiece and the plastic workpiece, bringing the front end of the pin, the sleeve and the clamping ring in contact with an outer surface of the metal workpiece, rotating the sleeve and the pin so as to generate friction between the front ends of the sleeve and the pin and the outer surface of the metal workpiece, and moving the pin and the sleeve in the axial direction while both are rotated, one of the sleeve and the pin penetrating into the metal workpiece and the other of the sleeve and the pin being retracted from the outer surface thereof. The axial movement into the metal workpiece is stopped before the one of the sleeve and the pin reaches the contact surface and after stopping the axial movement the one of the sleeve and the pin is retracted from the metal workpiece and the other is moved towards the outer surface of the metal surface until the front ends of the pin and the sleeve are on the same level.

The present invention relates to an isolated antibody or antigen-binding fragment thereof that specifically binds with high affinity to at least a portion of a segment of human prostate-derived Ets transcription factor (PDEF). The anti-PDEF antibody of the present invention is effective in prognostic and diagnostic assays for detecting PDEF with immunohistochemistry. The present invention also relates to methods of making the anti-PDEF antibody disclosed herein. The present invention further relates to vaccines against cancers associated with positive expression of PDEF, as well as methods for treating those cancers. Vectors, diagnostic kits, and hybridomas are also disclosed.

A pentacyclic anion salt is provided for use thereof in electrolyte compositions. The compound has an inorganic, organic or organometallic cation M of valency m (1≦m≦3) and m anions corresponding to the formula (I) in which Rf is a —CFZ′Z″ group in which Z′ is F or a perflouroalkyl group having from 1 to 3 carbon atoms, and Z″ is an H, F or Cl group, an optionally fluorinated or perfluorinated alkoxy group having from 1 to 5 carbon atoms, an optionally fluorinated or perfluorinated oxaalkoxy group having 1 to 5 carbon atoms or an optionally fluorinated or perfluorinated alkyl group having from 1 to 5 carbon atoms; Z″ being other than F when Z′ is F. An electrolyte composition comprises said salt in solution in a liquid solvent or a polymer solvent.

Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

A radio frequency power amplifier (RF PA) apparatus includes a first RF PA, a second RF PA, and a controller. The first RF PA is configured to deliver RF power to a load over a first range of RF power levels. The second RF PA is configured to deliver RF power to the load over a second range of RF power levels greater than the first range of RF power levels. The controller controls whether the first RF PA is delivering RF power to the load or the second RF PA is delivering RF power to the load, and is further configured to coordinate and control handoffs between the first and second RF PAs by varying magnitudes of input RF voltages applied to the RF input ports of the first and second RF PAs or by varying magnitudes of input bias voltages applied to the RF input ports of the first and second RF PAs.

The present invention provides for diagnostic kits for identifying cancer patients who are more susceptible to cancer therapies employing endostatin and other angiogenesis inhibitors, based upon the discovery that Nucleolin is a specific receptor for Endostatin. In particular, the diagnostic kits include antibody molecules against Nucleolin, DNA or RNA molecules that specifically bind to nucleic acid molecules encoding Nucleolin. The present invention also discloses methods of screening for angiogenesis inhibitors which specifically interact with Nucleolin, and act as angiogenesis inhibitors in an analogous manner as Endostatin. In addition, the present invention discloses methods of inhibiting the proliferation of endothelial cells or angiogenesis of tumor by administering an anti-nucleolin antibody linked to a cytotoxic agent such as tumor necrosis factor alpha to the endothelial cells.

The present invention relates to a flexible polymer-based microtube having an inner diameter of about 4 μm to about 1000 μm and a variable outer diameter, wherein the cross-sectional shape of the microtube can be, for instance, circular, rectangular, square, triangular, elliptical, star or irregular. The present invention also relates to a method of making the flexible microtube and devices incorporating the flexible microtube.

The present invention relates to a flexible polymer-based microtube having an inner diameter of about 4 μm to about 1000 μm and a variable outer diameter, wherein the cross-sectional shape of the microtube can be, for instance, circular, rectangular, square, triangular, elliptical, star or irregular. The present invention also relates to a method of making the flexible microtube and devices incorporating the flexible microtube.

A method for selectively removing a resist material from the polycationic surface of a polyelectrolyte multilayer (PEM) film, without disturbing adhering interactions between the cationic film surface and bound biomaterials such as cells, proteins, and nucleic acids. The resist material is one that that inhibits or prevents the further deposition of cells or other biomaterial; it thus masks the cationic surface from application of biomaterials. In one embodiment the resist material is a carboxy functional oxyalkylene oligomer. It is removed by exposing the film containing the bound biomaterial and the bound resist material to a pH below 4.5, and / or to a salt concentration of higher than 0.01 M.