70results about How to "Achieving Security Guarantees" patented technology

A system and method for ameliorating spinal column anomalies, such as scoliosis, includes bone screws which are to be implanted in the pedicle region(s) of individual to-be-derotated vertebrae and in vertebrae to which balancing forces must be applied as the spinal column is manipulated en mass to achieve an over-all correction of the condition. A pedicle screw cluster derotation tool simultaneously engages multiple pedicle screws and transmits manipulative forces to multiple vertebrae to effect a whole-spine correction. Pre-contoured spinal rods are engaged post-derotation to secure the correction.

An airbag device with an improved airbag configuration to protect a vehicle occupant more efficiently. The airbag device is stored in the upper portion of an instrument panel of a vehicle under normal situations. The airbag device has an airbag that is deployable into a space in front of a vehicle occupant in the event of a vehicle emergency, such as a collision. The airbag viewed from the top when fully deployed and inflated has a right side portion, a left side portion, and a recess between the right and left side portions. When pressure is applied to the right and left side portions, the recess maintains a recessed shape.

Methods of treating MDS, or ameliorating a symptom thereof, are disclosed. Specific methods encompass the administration of one or more vitamin D compounds, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with one or more additional active agents. Other methods include intermittent administration of a high dose of one or more vitamin D compounds, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with one or more additional active agents. Such intermittent administration allows high doses of the vitamin D compounds to be administered while minimizing or eliminating hypercalcemia.

The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition.

The invention is a wearable computer system comprised of a transferable core computer module and an enclosure which has been constructed to be instrinsically safe according to Class 1, Divisions 1, 2 or both of the U.S. Electrical Code. According to the system of the present invention, workers may make use of this system in environments in which typical electrical devices may not be used due to the presence of ambient ignitable gases and vapors. The enclosure may also be designed to have the properties of water tightness, air tightness and shock absorbtion.

It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

To provide an antitumor drug having excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. Provided is an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER3 antibody via a linker having a structure represented by the formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— or -L1-L2-LP- (the anti-HER3 antibody is connected to the terminal of L1, the antitumor compound is connected to the carbonyl group of —(CH2)n2-C(═O)— moiety or the C terminal of LP, with the nitrogen atom of the amino group at position 1 as a connecting position).

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

An electric vehicle includes a motor unit to drive a wheel. The electric vehicle also includes a control system that controls the motor unit. The control system includes an inverter. The electric vehicle also includes a temperature sensor to sense temperature Tmc of the motor coils of the motor unit or a temperature sensor to sense temperature Tic of the inverter. The electric vehicle also includes a limiter to, if the temperature Tmc sensed by the sensor exceeds a motor coils temperature threshold, reduce a motor current of the unit until a derivative dTmc / dt of the sensed temperature Tmc with time t drops to zero or below, or to, if the temperature Tic sensed by the sensor exceeds an inverter temperature threshold, limit a current command to the inverter until a derivative dTic / dt of the sensed temperature Tic with time t drops to zero or below.

An elevator arrangement includes a plurality of elevators in a building, which plurality includes a plurality of zoned elevators moving in an elevator hoistway, which have different ranges of movement of the elevator car in the building to each other, and which zoned elevators each have a top limit and a bottom limit of the range of movement of the elevator car, to above the top limit and to below the bottom limit of which range of movement travel of the elevator car of the zoned elevator in question is prevented. The vertical location, in relation to the building, of the top limit and / or bottom limit of the range of movement of the elevator car of each aforementioned zoned elevator can be changed. The arrangement also comprises a lobby elevator, the range of movement of the elevator car of which differs from the ranges of movement of the elevator cars of the aforementioned zoned elevators, and the stopping floors of the lobby elevator comprise a plurality of lobby floors, each of which is a stopping floor of one or more zoned elevators belonging to the aforementioned zoned elevator plurality. A method is provided for re-adjusting the elevator arrangement, wherein the range of movement of the elevator car of the zoned elevator in question is changed to reach to a different height in the elevator hoistway by changing the vertical location in relation to the building of the top limit and / or the bottom limit of the range of movement of the elevator car of the zoned elevator in question.

This application relates to radiation detection, and more particularly, to a method and device for the remote detection and localization of nuclear materials in an unknown background. A method and apparatus for long range neutron and gamma ray detection and imaging is disclosed wherein a panel of thin walled tube detectors are rotated to enhance detection performance. The method and apparatus have particular applicability to portable monitoring and homeland security.

A costume suit modeled after a large size animal having a head and mouth section, a neck section, a torso section, a foot section, a tail section, a skeletal part as a whole, and an outer skin part covering the whole is provided. The torso section is communicated with the foot section forming an internal hollow, just enough for an adult to fit at standing position. The hollow includes a frame pack fixed and installed to the skeletal part of the costume suit, in a position of an approximate equilibrium point of the costume suit. In the hollow, a means for manipulating a movement of the head and mouth section and the neck section, and a means for manipulating opening and closing of a mouth of the head and mouth section are equipped. Moreover, the skeletal part of the tail section is composed of a flexible tabular member placed in an internal hollow of the tail section, imitating a skeleton of a tail, and a plurality of foam blocks fixed and placed on the tabular member at certain intervals.

A battery electrode or separator surface protective agent composition having fluidity and being capable of being solidified by hot melt, and comprising at least two types of organic particles comprising organic materials, wherein the organic particles of types different from each other are substantially incompatible with each other, wherein when the composition is solidified by hot melt, the organic particles of the same type thermally fuse with one another to form a continuous phase.

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

A safer safety door, provided at low cost and imposing little burden on an operator. A primary safety door with a top and a secondary safety door are provided on a clamping unit. The primary safety door and the secondary safety door abut each other at abutting portions provided on each safety door. The secondary safety door has an engaging member that swings along a guide member. The engaging member has a hinge bent in one direction. When both safety doors are closed, the primary safety door can be freely opened and closed independently. When the secondary safety door is opened, both safety doors are linked together and move as a single body. In the state where the primary and secondary safety doors are opened separately, when the primary safety door is moved to be closed, the hinge member bends and both safety doors are linked together as a unit.