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113results about "Immunoglobulins against blood group antigens" patented technology

Production of proteins by cell culture

Methods for obtaining a protein by culture of hybridoma cells, wherein said protein is an immunoglobulin, are disclosed. The methods involve culturing animal hybridoma cells in continuous presence of an alkanoic acid or salt thereof, which enhances protein production, wherein said alkanoic acid or salt thereof is present at 2 concentration range of 0.1 mM to 200 mM.
Owner:LONZA LTD

Anti-platelet membrane glycoprotein vi monoclonal antibody

InactiveUS20090041783A1Decrease platelet aggregabilitySuppresses collagen-induced human platelet aggregationImmunoglobulins against blood group antigensAntibody mimetics/scaffoldsHuman plateletNormal platelet morphology
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof:a) It specifically binds to human platelet membrane glycoprotein VI (GPVI);b) The function to activate a platelet and / or the function to induce a thrombocytopenia in vivo are low; andc) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
Owner:MOCHIDA PHARM CO LTD

Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (GARP) and for providing effective immunotherapy alone or in combination

Isolated or recombinant monoclonal antibodies that bind to GARP are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and / or therapeutic treatment of human diseases, such as cancer. Further provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of an anti-platelet agent and a T cell therapy.
Owner:MUSC FOUND FOR RES DEV

RH blood group antigen compositions and methods of use

Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
Owner:RODKEY L SCOTT +2
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