The invention discloses a separator for bone and meat separation, which comprises a base box, a separation cylinder is fixedly arranged above the base box, and a transmission shaft extends into a feeding trough on which a plurality of first separating cylinders are fixedly arranged. Knives; a section of the rotating shaft close to the feed tank is fixedly provided with a plurality of second separating knives, and other sections of the rotating shaft are fixedly provided with screw auger blades; the separating cylinder is provided with a plurality of inner leakage holes, A plurality of leak holes and grooves are opened on the outer drum, guide rails are arranged in the grooves, slide plates are movable between the guide rails, and the slide plates are connected with the bottom wall of the groove. There is a spring, and a brush is fixedly arranged on the side of the slide plate away from the spring. The invention provides a separator for bone and meat separation, which can regulate and limit the size of the separated meat particles, and can also clean the internal leakage hole after use, clean and odorless, simple in operation, and simple in structure. Well worth promoting.