The present disclosure provides devices for processing, such as staining, a tissue sample on a microscope slide. In some embodiments, the tissue staining device described herein is capable of, e.g., automating, in whole or in part, a tissue staining protocol (including a chemical staining protocol and / or an immuno-based staining protocol) or a tissue dehydration protocol. Also provided in other aspects of the disclosure are components, methods of use, systems, and kits associated with the devices described herein.