The invention relates to a logistics management method utilizing real-time configuration of a storage space and a distribution route. The logistics management method is characterized in that a range defined in the storage space is used for temporary storage of the express packages to be sent, and the express packages to be sent are collected for the logistics vehicle in the current storage space through the distribution destination or the transfer place according to the driving route and the unloading and loading process, and the express packages to be transferred are unloaded to replace sorting, so that, a large amount of inbound and sorting time can be saved; and meanwhile, the storage space can be arranged nearby a parcel collecting place of the express parcel, and then the fragmentaryidle space distributed in the whole city is fully utilized, and global overall management is conducted through artificial intelligence, and precise loading and unloading and space management are conducted through the logistics robot, and logistics enterprises can save a large amount of storage space manpower cost and management cost. According to the embodiment of the invention, a traditional logistics mode can be improved, and the efficiency of the logistics process is greatly improved, and the storage cost can be greatly saved.