The invention discloses a multi-mode medical image registration method based on edge features and CS (Cauchy-Schwarz) information. Based on the principle of a generalized morphological filter, the method disclosed by invention improves the morphological gradient operator and performs image edge detection by use of a new gradient filtering operator so as to improve the computing speed and anti-noise performance of the image edge detection and quickly realize rough detection of the image edge, and determines the coordinates and direction of the image edge point to lay a foundation for the subsequent image registration; the method constructs a new CS geometrical information measure according to a CS inequality, wherein the measuring method does not involve division and logarithm arithmetic in the mathematical computation process, and can effectively reduce the computing complexity in image registration and improve the computing efficiency; and moreover, the method adopts a Powell method to optimize registration parameters, does not need to derivate a target function, has quadratic convergence and high convergence speed, and is conveniently realized by programming. Compared with the prior art, the method disclosed by the invention has better performance in computing standard deviation, information amount, average computing time and the like, and has better robustness.