58 results about "Macular oedema" patented technology

A compound of the formula (I): R<1>-NH-X-Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

A compound of the formula (I): R1—NH—X—Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

The invention discloses a composition for treating eye diseases by double-target / multi-target small nucleic acid and applications of the composition. The composition comprises two small nucleic acid molecules and a medicinal carrier, target genes of the two small nucleic acid molecules are selected from two of VEGF (vascular endothelial growth factor) gene, VEGFR2 (vascular endothelial growth factor receptor2) gene and TGF-b1 (transforming growth factor-beta1) gene; or the composition comprises three small nucleic acid molecules and a medicinal carrier, and target genes of the three small nucleic acid molecules are respectively VEGF gene, VEGFR2 gene and TGF-b1 gene. The composition can be used for effectively treating eye diseases by virtue of ribonucleic acid interference (RNAi) mediated inhibitor gene expression and biochemical pathway, and can be prepared to form a medicament for treating eye diseases, including proliferatived diabetic retinophathy, diabetic macular edema, herpes simplex interstitial keratitis, age-related macular degeneration, uveitis and the like.

The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.

The present invention relates to methods, devices, and compositions for treating ocular disorders such as uveitis, macular edema associated with uveitis, and diabetic macular edema. For example, the methods include treatment of subjects having macular edema associated with non-infectious uveitis, or diabetic macular edema, by administering to the subjects a triamcinolone composition via non-surgical administration to the suprachoroidal space (SCS) of the eye.

The invention discloses a composition for treating fundus macular oedema and application of the composition in treatment of eye diseases and belongs to the technical field of medicines. The composition for treating the fundus macular oedema comprises the following components in percentage by weight: 0.4-71% of (a) polyphenolic compounds, 0.6-93% of (b) lipoic acid, dihydrolipoic acid, lipoic acid salt or lipoamide, 0-97% of (c) ubiquinone or panthenol and 0-87% of (d) docosahexaenoic acid or ethyl ester thereof and / or timnodonic acid or ethyl ester thereof. The composition can be used for improving patient visual acuity, stabilizing intraocular pressure and reducing various ocular inflammations such as the fundus macular oedema. By means of the composition for treating the fundus macular oedema and a treatment method, the fundus macular oedema can be prevented, stabilized, controlled or treated and the fundus health can be enhanced; in the meantime, the intraocular pressure can be stabilized, the vision can be maintained or improved, various eye diseases or macular oedema and inflammation which are caused by eye operations can be reduced; the diabetic complication is also treated, the blood microcirculation is promoted and the liver function is improved.

This invention relates to CXCR4 inhibitors and their use in treating and / or preventing a variety of angiogenic, microvascular and ocular disorders including primary indications for diabetic retinopathy, macular degeneration (such as wet or neovascular age-related macular degeneration (AMD) and dry or atrophic AMD), macular edema, and secondary indications for inhibiting tumor vascularization, and corneal and iris neovascularization.

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), or a salt or an ester thereof, are provided for use in the treatment and / or prophylaxis of a condition selected from macular oedema, conditions causing damage to retinal photoreceptors and / or retinal pigment epithelial cells, and dry eyes in a mammal, wherein the combined dosage of eicosapentaenoic acid and docosahexaenoic acid is from 5 mmol to 25 mmol per day, and wherein the molar ratio of eicosapentaenoic acid to docosahexaenoic acid is in the range of from 1:1 to 5:1. Compositions comprising EPA and DHA and at least one pharmaceutically acceptable excipient, and kits containing EPA, DHA and further therapeutic agents are also provided. The EPA and DHA, or composition comprising the EPA and DHA may be administered orally.

This invention relates to the use of a heparanase inhibitor for treating, or inhibiting the progression or development of, an ocular inflammatory disorder, such as age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, retinal 5 vein occlusion, retinoblastoma, uveitis, macular edema, dry eye, ocular inflammation associated with an infection or keratoconus.

The invention relates to an application of secretory granulin III as a drug target in preparing drugs for treating vascular hyperplastic or exudative diseases. The Scg 3 function is inhibited by adopting drug therapy, and the Scg3 can treat diabetic retinopathy, diabetic macular edema, vascular proliferation type diabetic retinopathy, vascular proliferation type senile macular degeneration, diabetic foot diseases and various tumors. Scg3 is characterized by disease specificity. Therefore, the anti-Scg3 therapy is characterized by selectively inhibiting the proliferation or exudation of diseased blood vessels with minimal side effects on normal blood vessels.

The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1), a pharmaceutical composition comprising the compound or a salt, hydrate or solvate thereof as an active ingredient, a method for the prevention or the treatment of a SSAO / VAP-1 related disease, said diseases including acute or chronic inflammatory diseases, diseases related to carbohydrate metabolism, diabetes-associated complications, diabetic retinopathy and macular oedema, diseases related to adipocyte or smooth muscle dysfunctions, neurodegenerative diseases and vascular diseases.

The present disclosure relates to a novel use of a sesquiterpene derivative, more particularly to a composition for preventing, improving or treating macular degeneration or macular edema caused by vascular leakage in the eye, the composition containing a sesquiterpene derivative compound represented by Chemical Formula 1 of the present disclosure or a pharmaceutically acceptable salt thereof as an active ingredient. Whereas the intraocular disease-related treating agents available in the market should be injected directly into the vitreous cavity, thus causing pain and side effects, the sesquiterpene derivative compound of the present disclosure is delivered to the target tissue (eye) via different administration routes (oral, intraperitoneal, etc.) other than the intravitreal route. Accordingly, the sesquiterpene derivative compound provides excellent therapeutic effect without being restricted by the administration routes.

The invention provides application of total flavones of hippophae rhamnoides in preparation of treating diabetic retinopathy. The invention also provides a medicine composition for treating the diabetic retinopathy. The medicinal flavonoid compound can be used for resisting the oxidative damage of hydrogen peroxide, improving the activity of cells as well as the oxidation reduction function, and bringing protection to the retinal pigment epithelium (RPE), so that photoreceptor cells can be protected, the macular oedema is reduced, the vision is improved, and the total flavones of hippophae rhamnoides are expected to be developed into a new medicine for treating the diabetic retinopathy.

The invention provides application of a composition prepared from radix astragali, radix puerariae and herba erigerontis to preparation of drugs for treating or preventing macular oedema of individuals.

The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.