The invention provides a chain drive mechanism for a bottom-positioned venetian blind, which consists of a left metal chain, a right metal chain, a left upper sprocket wheel, a right upper sprocket wheel, a left lower friction wheel, a right lower friction wheel, a drive shaft, a trip shaft, a support, a moving groove and a chain chute, wherein one end of the left metal chain is fixed on the leftupper part of a window frame, while the other end is a free end; after the left metal chain rounds the left lower friction wheel and the left upper sprocket wheel, the left metal chain is freely suspended in the chain chute; one end of the right metal chain is fixed on the right upper part of the window frame, while the other end is a free end; after the right metal chain rounds the right lower friction wheel and the right upper sprocket wheel, the right metal chain is freely suspended in the chain chute; the left lower friction wheel and the right lower friction wheel are arranged on two ends of the trip shaft; the trip shaft passes through the support and is supported by the support; the support is connected with the moving groove; the left upper sprocket wheel and the right upper sprocket wheel are arranged on two ends of the drive shaft; and when a power system of the venetian blind starts to run, the whole drive mechanism of the venetian blind starts to work. The chain drive mechanism has the advantages of simple and easy operation and convenient use.