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38 results about "AutoAnalyzer" patented technology

The AutoAnalyzer is an automated analyzer using a flow technique called continuous flow analysis (CFA), or more correctly Segmented Flow Analysis (SFA) first made by the Technicon Corporation. The instrument was invented in 1957 by Leonard Skeggs, PhD and commercialized by Jack Whitehead's Technicon Corporation. The first applications were for clinical analysis, but methods for industrial and environmental analysis soon followed. The design is based on segmenting a continuously flowing stream with air bubbles.

Autoanalyzer

Dispensing failure occurs when air-sucking or clogging is caused at the time of sucking sample or reagent by using a dispensing probe. An automatic analyzer is equipped with a dispensing mechanism (15) for dispensing the sample into a reaction container (35) from a reagent container (10) and an analysis means (61) for analyzing contents within the reaction container (35), wherein the dispensing mechanism (15) includes a pressure generation mechanism (69) for changing the pressure within a nozzle and a dispensing flow path (24) for coupling between the nozzle and the pressure generation mechanism (69) and containing pressure transmission medium therein; and further includes an oscillator (27) for applying vibration of a particular frequency to the pressure transmission medium within the flow path, a pressure sensor (26) for detecting the pressure within the flow path, and a mechanism (76) for detecting whether or not the sample is sucked normally into the nozzle based on the amplitude or the phase difference of the component of the particular frequency extracted from the output of the pressure sensor (26).
Owner:HITACHI HIGH-TECH CORP

Autoanalyzer and pipetting nozzle for autoanalyzer

ActiveUS20110300035A1Superior in cutting off sample drippingLess liableMaterial analysis by optical meansBurettes/pipettesAutoAnalyzerContamination
There is provided a highly reliable autoanalyzer less liable to sample and reagent carry-over and capable of preventing contamination and precisely pipetting samples and reagents. Using a sample pipetting nozzle 27 having water-repellent surfaces, a sample is pipetted from a sample cell 25 to a reaction cell 4 having a hydrophilic bottom face.
Owner:HITACHI HIGH-TECH CORP

Method and kit for quantitatively determining small, dense ldl cholesterol

A method for fractional measurement of small, dense LDL, which is adaptable for an autoanalyzer, and a reagent for measurement, are provided, making it possible to conduct rapid and convenient analysis with good sensitivity without pretreatment of a specimen. The method for quantitatively determining small, dense LDL cholesterol in a sample comprises the steps of:(1) eliminating cholesterol in LDL other than small, dense LDL in the presence of phospholipase; and(2) quantitatively determining cholesterol in lipoproteins remaining in step (1) above.
Owner:DENKA CO LTD

Autoanalyzer

Provided is an autoanalyzer which is equipped with a reagent disc having a plurality of reagent containers mounted thereon and performs qualitative / quantitative analysis of a living body sample such as blood or urine, wherein measurement error of the liquid level of reagent caused by swinging of the liquid surface incident to rotary operation of the reagent disc is reduced. Assuming a predetermined cycle time is one unit, the reagent disc having the reagent containers mounted thereon is transported to a liquid level detection position using two units or more when the liquid level of the reagent is measured.
Owner:HITACHI HIGH-TECH CORP

Method and kit for quantitative determination for small, dense particle low density lipoproteins

A rapid and convenient method capable of performing fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable for an autoanalyzer, is provided. A method for quantitatively determining small, dense LDL cholesterol is provided, which comprises adding enzymes for cholesterol measurement to a test sample in the presence of a polyoxyethylene-polyoxypropylene copolymer or a derivative thereof, causing the polyoxyethylene-polyoxypropylene copolymer or the derivative thereof to selectively act on small, dense LDLs among lipoproteins, and then measuring the amount of cholesterol generated.
Owner:DENKA CO LTD

Autoanalyzer and probe elevating method

An autoanalyzer includes a measurement unit which measures a reaction liquid produced by an interaction between a reagent and an examined sample contained in a reaction container, a sample probe which sucks the examined sample from a sample container and discharges the examined sample to the reaction container, a probe elevating arm which elevates the sample probe with respect to the sample container, and a control unit which controls the probe elevating arm so that a speed at which the sample probe enters a liquid surface of the examined sample to perform an n-th suction operation (n≧2) of the examined sample is slower than a speed at which the sample probe enters the liquid surface of the examined sample to perform a first suction operation of the examined sample.
Owner:TOSHIBA MEDICAL SYST CORP

Apparatus for auto-pretreating sugar chain

To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample, which comprises the following steps: A) the sugar chain-releasing step of releasing the sugar chain in the sample; B) the detection sample-preparing step of preparing the released sugar chain for detection; and, in the case of conducting mass spectrometry using a plate, C) the step of forming a plate for the mass spectrometry having the captured sugar chain dotted thereon which comprises the step of providing the tagged sugar chain sample solution obtained in the step B) on a collection plate; and, if required, the step of conducting an operation in a solid phase support-enclosed plate to form the plate for mass spectrometry; and D) the step of analyzing the sugar chain to be assayed.
Owner:SUMITOMO BAKELITE CO LTD +1

Automatic analyzer and method for washing sample-pipetting probe

When the type is to be changed from serum (preceding sample) to urine (current sample), “serum” is set to a preceding type and “urine” is set to a measurement type at number 1 in a condition number. At condition number 1, the wash type is pattern 1, with washing performed once with detergent 1. Where the preceding sample is serum and the current sample is CSF, the condition number is 2 and the wash type is pattern 2, with washing performed twice using detergent 1 and once with detergent 2. Where the preceding sample is urine and the current sample is CSF, the condition number is 3 and the wash type is pattern 3, with washing performed once with detergent 1, once with detergent 2, and once with water. In the case of pattern 4, washing is performed three times with detergent 1.
Owner:HITACHI HIGH-TECH CORP

Liquid Exchange Method, Ingredient Extraction Method Using the Same, Composite Container and Autoanalyzer

A liquid exchange method of exchanging liquids present around a magnetic substance is provided. The method serves to prevent a remaining liquid from transferring to a next step and a loss of the magnetic substance. Even when the liquid exchange method is applied to an autoanalyzer, the device structure will not be complicated. A vessel 11 in which a liquid 16 containing a magnetic substance 15, a vessel 12 containing a liquid 17, a magnetic substance move-mediating member 13 and also a magnet 18 are prepared. The magnet 18 is disposed at the exterior of the vessel 11, and the magnet 18 is moved to move the magnetic substance 15 on the inner wall face of the vessel 11 in order to take out the magnetic substance 15 from the magnetic substance containing liquid 16, to move the magnetic substance 15 from the inner wall face of the vessel 11 to the surface of the magnetic substance move-mediating member 13, and to move to the inner wall face of the other vessel 12 via the magnetic substance move-mediating member 13 so as to introduce the magnetic substance 15 into the liquid 17 in the vessel 12, thereby exchanging the liquids present around the magnetic substance 15.
Owner:ARKRAY INC

Method of determining iron concentration

A method of determining the concentration of iron in a sample, characterized by bringing the iron contained in the sample into contact with an iron-chelating color former in the presence of lithium ions and determining the iron concentration based on the degree of the resultant coloring; and a reagent and kit for iron determination which are for use in the method. This method eliminates the conventional problem that found values obtained are low as compared with ones obtained by the international standard method. This method does not necessitate a complicated operation, e.g., protein removal, and enables the determination of an iron concentration with an autoanalyzer. Since found values obtained by the method are close to ones obtained by the standard addition method according to the international standard method, more accurate determination is possible.
Owner:WAKO PURE CHEMICAL INDUSTRIES

Connected Reagent Container

Provided is a composite multi-reagent vessel for an autoanalyzer, which prevents incorrectly combining a plurality of reagents including a standard or a control, and eliminates the work for combining reagents for analysis. A plurality of containers are each capable of standing on their own and are connected together each with an opening portion at the top and each being detachable and capable of standing as the connected reagent containers, thereby forming the composite multi-reagent vessel for the autoanalyzer to have reagents for analyzing the same analytical item therein, and a small container to have a reagent therein that is held on a step or a concave portion formed at a shoulder portion of any of the connected reagent containers.
Owner:WAKO PURE CHEMICAL INDUSTRIES

REAGENT FOR QUANTITATIVE DETERMINATION OF SMALL, DENSE LDLs

A reagent for fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable to a rapid and convenient autoanalyzer, is provided. A method for quantitatively determining cholesterol in small, dense LDLs in a sample is further provided, comprising: a first step of eliminating lipoproteins other than small, dense LDLs in a sample in the presence of cholesterol esterase and 0.05 g / L to 1.0 g / L of a surfactant that acts on the lipoproteins other than small, dense LDLs; and a second step of quantitatively determining cholesterol in small, dense LDLs that remain after the first step.
Owner:DENKA CO LTD

High-concentration glucose removal method and kit for determining serum 1,5 anhydro-D-glucitol based on pyranose oxidase method

The invention discloses a high-concentration glucose removal method for determining serum 1,5 anhydro-D-glucitol based on a pyranose oxidase method, which comprises the following steps: preparing a 2-morpholinoethanesulfonic acid (MES) buffer solution having a pH value of 6.0-9.0, wherein the MES buffer solution contains a certain amount of glucokinase (GK), glucose-6-phosphate dehydrogenase (G6PD), nicotinamide adenine dinucleotide phosphate (NADP), pyruvate kinase (PK), phosphoenolpyruvate (PEP) and adenosine triphosphate (ATP); and adding into a serum sample containing glucose (Glu), and reacting at 20-50 DEG C for 3-5 minutes, wherein the GK converts the Glu into glucose-6-phosphoric acid (G6P) in the presence of the ATP, and adenosine diphosphate (ADP) is generated at the same time; the G6P is further converted into glucose-6-phosphate lactone (G6PL) by the G6PD in the presence of the NADP+; and the ADP generated in the reaction is converted into ATP again under the action of thePK in the presence of the PEP. The glucose removal agent prepared by the method can be stably stored at 2-8 DEG C for 14 months, and can be used for a clinical biochemical autoanalyzer extensively used at present.
Owner:浙江夸克生物科技有限公司

Autoanalyzer

ActiveCN102378916AConsistent timingValid checkMaterial analysisEngineeringCycle time
Provided is an autoanalyzer which can perform inspection of a plurality of items efficiently while arranging the timing of dispensing a sample and simplifying the configuration. An intermediate disc (disc) sets to use n B cycles as the dispensing operation cycle time of a sample by combining the A cycle for carrying out pretreatment operation, and the B cycle for carrying out dispensing operation of the sample to a reaction disc as an inspection mechanism and a flow system analysis mechanism. In other words, the operation cycle time for re-dispensing (dispensing operation cycle time for the inspection mechanism of a plurality of items) is set equal to n times (n is an integer or an intermediate value between integers) of the minimum operation cycle time. Consequently, the timing of sampling can be arranged efficiently so that the inspection of items with a short analysis cycle is carried out during the inspection of items with a long analysis cycle, or the inspection of items with a large number of requests can be carried out between the inspections of items with a small number of requests.
Owner:HITACHI HIGH-TECH CORP

Dispensing Nozzle for Autoanalyzer, Autoanalyzer Equipped with the Nozzle, and Method for Producing Dispensing Nozzle for Autoanalyzer

In an autoanalyzer for analyzing a specimen such as urine and blood, protecting a measurement value of analysis from influence of a dispensing nozzle repeatedly used. For this purpose, a phosphonic acid derivative or a phosphoric acid derivative is chemically adsorbed on the surface of the dispensing nozzle. In this manner, a molecular layer for suppressing adsorption of biopolymers or adhesion of a specimen per se is formed on the nozzle surface to prevent accuracy of analysis from being influenced.
Owner:HITACHI HIGH-TECH CORP

System for intelligently controlling dosing amount in heavy metal wastewater treatment

The invention relates to the technical field of wastewater treatment and particularly relates to a system for intelligently controlling dosing amount in heavy metal wastewater treatment. The system includes, in a successively connected manner, a first water quality auto-analysis device, a first flow sensor, a reaction tank, a second water quality auto-analysis device, a first electric valve and asecond flow sensor, and also includes a backflow bypass connected between the second water quality auto-analysis device and the first electric valve. The backflow bypass is successively provided witha second electric valve and a third flow sensor. The system further includes a reagent metering pump connected to the reaction tank, and an intelligent control system respectively connected to the first water quality auto-analysis device, the second water quality auto-analysis device, the flow sensor and the reagent metering pump through signals. During control of dosing amount, the system can change the dose by fluctuation of heavy metal content in the wastewater, so that on the basis of guaranteeing the effluent quality, waste of the reagent is reduced, and quantity of sludge is reduced, misjudgment rate by manual work is reduced, and high efficiency and manpower saving are achieved.
Owner:GUANGREEN ENVIRONMENTAL PROTECTION ENG

Automatic analyzer

An automatic analyzer and an automatic analyzing system to identify samples and reagents used in the analyzer and members used in measurement of at least two objects in common: system reagents or buffer solution; sensor parts; probes; nozzles; chips; dispensing cups; tubes; ISE electrodes; detectors; deionized water; and waste, and to unify management of identification information thereof and a measurement result.
Owner:HITACHI HIGH-TECH CORP

Pipetting nozzle for autoanalyzer, method for producing same and autoanalyzer using same

In an autoanalyzer for analyzing samples, such as urine and blood, analytical and measured values are prevented from being affected by carry-over caused by the repeated use of a pipetting nozzle. A molecular layer for inhibiting the adsorption of biological polymers is formed by coating surfaces of the pipetting nozzle with a polyethylene glycol derivative chemisorbed thereto, thereby reducing carry-over caused by the pipetting nozzle.
Owner:HITACHI HIGH-TECH CORP

Methods for determining the concentration of gamma-hydroxy butyric acid (GHB) in a sample

Methods to determine the concentration of gamma-hydroxy butyric acid (GHB) in a sample as well as compositions and a kit suitable for carrying out said methods. Also, the use of the methods for application on a microtiter plate or an auto-analyzer.
Owner:BUHLMANN LAB AG

Reagent for quantitative determination of small, dense LDLs

A reagent for fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable to a rapid and convenient autoanalyzer, is provided. A method for quantitatively determining cholesterol in small, dense LDLs in a sample is further provided. The method includes first step of eliminating lipoproteins other than small, dense LDLs in a sample in the presence of cholesterol esterase and 0.05 g / L to 1.0 g / L of a surfactant that acts on the lipoproteins other than small, dense LDLs, and a second step of quantitatively determining cholesterol in small dense LDLs that remain after the first step.
Owner:DENKA CO LTD

Automatic analyzer and the analyzing method using the same

An automatic analyzer which assures uniformity in mixing effects regardless of sample quantity and test item and thus produces analysis results with high repeatability. The automatic analyzer includes a device for adding a conditioning liquid into a reaction chamber so that the quantity of liquid in the reaction chamber becomes a predetermined quantity prior to being mixed. The conditioning liquid may be a diluent or physiological saline as used for dilution of a sample or any other special liquid that adjusts the properties such as viscosity, surface tension, etc. of liquid to be mixed.
Owner:HITACHI HIGH-TECH CORP

Autoanalyzer and probe elevating method

An autoanalyzer includes a measurement unit which measures a reaction liquid produced by an interaction between a reagent and an examined sample contained in a reaction container, a sample probe which sucks the examined sample from a sample container and discharges the examined sample to the reaction container, a probe elevating arm which elevates the sample probe with respect to the sample container, and a control unit which controls the probe elevating arm so that a speed at which the sample probe enters a liquid surface of the examined sample to perform an n-th suction operation (n≧2) of the examined sample is slower than a speed at which the sample probe enters the liquid surface of the examined sample to perform a first suction operation of the examined sample.
Owner:TOSHIBA MEDICAL SYST CORP

Method and kit for quantitatively determining small, dense LDL cholesterol

A method for fractional measurement of small, dense LDL, which is adaptable for an autoanalyzer, and a reagent for measurement, are provided, making it possible to conduct rapid and convenient analysis with good sensitivity without pretreatment of a specimen. The method for quantitatively determining small, dense LDL cholesterol in a sample comprises the steps of:(1) eliminating cholesterol in LDL other than small, dense LDL in the presence of phospholipase; and(2) quantitatively determining cholesterol in lipoproteins remaining in step (1) above.
Owner:DENKA CO LTD
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