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Zinc oxide coating modified in vivo implanted artificial organ and preparation method thereof

An artificial organ, zinc oxide film technology, applied in the direction of metal material coating process, coating, prosthesis, etc., can solve the problems of poor blood compatibility, limited application scope, poor biocompatibility, etc., and achieve good compactness. , good repeatability, low cost effect

Inactive Publication Date: 2010-06-23
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, most of the artificial organs implanted in the body are made of titanium alloy or stainless steel, which have good mechanical properties, but poor biocompatibility, especially the artificial organs in contact with blood, which show poor blood compatibility. Easy to form blood clots, which limits its scope of application

Method used

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  • Zinc oxide coating modified in vivo implanted artificial organ and preparation method thereof
  • Zinc oxide coating modified in vivo implanted artificial organ and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Preparation of zinc oxide film coating by radio frequency magnetron sputtering

[0044] Using RF magnetron sputtering method, the background vacuum is 3.0×10 -3 Pa, high-purity argon (99.99%) is used as the sputtering gas, the working pressure is between 4 Pa, titanium alloy is selected as the base, and the deposition substrate temperature (the surface temperature of the base that carries the artificial organ substrate during sputtering) is room temperature To 300℃, adjust the power of RF sputtering to 50~190W, the RF voltage is 500~1000V, for 99.99% zinc oxide ceramic target and different doping concentration (molar content of light rare earth element) zinc oxide ceramic target (see below Table 1) Sputtering was performed to prepare a series of zinc oxide thin film coatings.

[0045] Table 1

[0046] Doping element

Embodiment 2

[0048] Zinc oxide film coating deposited by magnetic filtered arc ion plating in pure oxygen atmosphere

[0049] Using the method of magnetic filtered arc ion plating, the background vacuum is 6.0×10 -3 Pa, select titanium alloy as the substrate, clean with argon ion for 10 minutes, magnetic filter solenoid current 7.15A, central magnetic field is 12.0mT, high purity oxygen (99.99%) is used as reaction gas, and oxygen flow is changed to control working pressure. 99.9% metallic zinc was used as the cathode target to prepare a series of zinc oxide thin film coatings (see Table 2 below).

[0050] Table 2

[0051] Oxygen flow

Embodiment 3

[0053] Deposition of zinc oxide film coating in mixed gas atmosphere by magnetic filtered arc ion plating

[0054] Using the method of magnetic filtered arc ion plating, the background vacuum is 6.0×10 -3 Pa, select titanium alloy as the substrate, clean with argon ions for 10 minutes, magnetic filter solenoid current 7.15A, and center magnetic field 12.0mT. Pass in mixed gas, use argon and nitrogen as protective gas, control the flow ratio of argon and nitrogen, and then pass in reactive gas oxygen to change the working pressure to control the working pressure, the arc current is 30-40A, and the arc voltage is 30-40V Using 99.9% metallic zinc as the cathode target, a series of zinc oxide thin film coatings were prepared (see Table 3 below).

[0055] table 3

[0056] Argon nitrogen flow ratio

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Abstract

The invention discloses an artificial organ used for in vivo implantation, which comprises an artificial organ matrix and an artificial organ surface modified layer, wherein the surface modified layer is a zinc oxide thin film the thickness of which is 10nm to 700nm, preferably a zinc oxide thin film the thickness of which is 200nm to 400nm. The zinc oxide thin film is doped preferably by light rare earth elements. The invention also discloses two methods for preparing the artificial organ the surface of which is modified by the zinc oxide coating, wherein in one method, a layer of pure or light rare earth-doped transparent zinc oxide thin film is prepared on the surface of the in vivo implanted artificial organ by adopting a radio frequency magnetic control sputtering technology to serve as a biological coating for improving an implant anticoagulant property; in the other method, the transparent zinc oxide thin film is deposited by adopting a method of magnetic filtration arc ion plating. The anticoagulant property and the mechanical property of the in vivo implanted artificial organ are improved.

Description

Technical field [0001] The present invention relates to a method for surface modification of inorganic materials, especially a method for preparing and surface modification of zinc oxide film. Background technique [0002] Biological materials are in direct contact with human tissues, so higher requirements are placed on the surface of the materials. As a biomedical material for human implants, it must meet the following conditions: (1) Blood compatibility and tissue compatibility to ensure that the implant will not cause thrombus formation and will not damage the surrounding tissues; 2) Chemical stability, the implant will not produce degradation; (3) Good mechanical properties, with low friction coefficient, high hardness, good toughness, fatigue resistance, corrosion resistance and other properties. [0003] The currently extensively studied blood compatibility materials can be summarized into three categories, one is medical polymer materials, the other is metal and metal oxid...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L27/04A61L31/08A61L31/02C23C14/35C23C14/08C23C14/06C23C14/32
Inventor 陈弟虎何振辉黄展云潘仕荣
Owner SUN YAT SEN UNIV
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