An integrated optimized unlocking device of a drawer panel comprises an adjusting seat and an adjusting box body which are arranged in a drawer side plate, and the drawer panel is connected with the adjusting seat or the adjusting box body through a connecting piece; the adjusting box body is arranged on the adjusting seat and made of sheet metal, at least one relatively independent locking mechanism is arranged on the adjusting box body, an unlocking piece and a slider are arranged corresponding to the locking mechanism, and the connecting piece can be detached and separated from the locking mechanism through the match of the unlocking piece and the slider. The adjusting box body is made of metal, so that the strength of the product is effectively enhanced; while the production technology is simplified, the slider is arranged on the adjusting box body in a sliding mode through a metal sliding column, so that the friction between the slider and the adjusting box body is reduced; moreover, the unlocking piece, the slider and the locking mechanism are matched in a friction mode through plastic pieces and provided with at least one curved surface connection, so that the friction and the abrasion of the contact portions among all the components are greatly reduced, the service life of the product is prolonged, and the purpose of smooth and reliable assembly and disassembly of the panel can be achieved.