The present invention relates to compounds of Formula (I):or a pharmaceutically acceptable salt thereof, wherein: each of A, B, C, D, and E, independently, is C, N, N—H, O, S, or absent is a
single bond or a
double bond; each of X, Y, and Z, independently, is
aryl, heteroaryl, aralkyl, H, or absent; each of L1 and L2, independently, is a
moiety selected from O, CH2, C═O, C2-10
alkyl, C2-10 alkenyl, C2-10 alkynyl, —((CH2)n—W)—, wherein n=0, 1, 2, 3, 4, or 5, and W is O or S, or absent; and when L2 is absent, Z is
aryl or heteroaryl fused with BC. Also provided in the present invention is a method for inhibiting, treating and / or reducing the risk of a
neuropsychiatric disorder, comprising administering a subject in need a composition comprising a compound of Formula (I).