The invention relates to the technical field of hot melt adhesives, in particular to hot melt adhesive powder, which is prepared from the following components in parts by weight: 20 to 55 parts of aliphatic seriesdihydric alcohol, 30 to 60 parts of binary acid, 15 to 30 parts of dimethyl terephthalate, 0.1 to 2 parts of titanium catalyst, 0.1 to 2 parts of stabilizer, 0.1 to 2 parts of antioxidant,and 0.1 to 2 parts of composite nucleating agent. Compared with the prior art, the hot melt adhesive powder provided by the invention adopts the aliphatic seriesdihydric alcohol, the binary acid and the dimethyl terephthalate as a synthesis system, a composite additive is added, and the polyester is modified, so that the hot melt adhesive powder has a good adhesion force; particularly, after the composite nucleating agent is added, the hot melt adhesive powder is fast in curing speed, has the shore hardness being 70, the softening point being 175 DEG C, the resistance to low temperature of minus 45 DEG C, the peeling strength being 6.8N / mm, and the elongation being 620 percent, has good low temperature flexibility and adhesion, is particularly suitable for various sizing machines for lasting, realizes automatic sizing, is good in processing performance and low in cost, and is beneficial to greatly reducing the processing cost of shoes.