The invention discloses a prawn luminous vibriosis pond treatment method. According to the method, based on the ecological characteristics of pond luminous vibriosis, the water salinity of the prawn luminous vibriosis pond is desalted at the initial death stage of prawns, meanwhile, the luminous vibriosis is restrained through disinfectant, dead prawns are discharged in time for reducing propagation in the pond, the water color and prawns are protected in time, finally, pond pathogenic bacteria are completely restrained, pond treatment is finished, and the healthy ingestion and growth of prawns are facilitated. The novel disinfectant is selected, and compared with traditional antibacterial agents, interference on growth of water physical and chemical factors, algae and prawns can be greatly lowered. The method has the advantages that the efficiency is high, toxicity is low, additive residence time is short, and influences on water algae are small. The pond treatment method can also be used for preventing and treating the pond with vibriosis caused by vibrios growing normally only with a certain salinity.