The invention discloses an express separation and self-fetching terminal system and method based on a three-axis mobile platform, and belongs to the technical field of intelligent logistics terminals.The system includes an article inputting platform, the three-axis mobile platform, express storage cabinets, a pickup terminal, a camera recognition module and a system information management module;the method comprises the following steps that step 1, a package enters a system device through an article inlet port and is temporarily stored on a loading platform, and a mechanical arm is pushed topick up a single package; step 2, according to bar code information and package size information collected by the camera recognition module, the express storage cabinets are automatically allocated for current packages, and the three-axis mobile platform intelligently separates and stores articles; step 3, the system notifies that there is a self-fetching article by means of short messages, the system automatically finds and compares a pick-up code when the article is picked up, the three-axis mobile platform takes the article out of the storage cabinet, and a pickup result is fed back to thesystem information management module for next-step processing. The method is convenient, fast and reliable, greatly improves the speed rate of an express logistics terminal, and has strong practicability.