The invention provides a configuration-based twinning synchronization method, which comprises the following steps of S1, defining a configuration twinning processing framework, and setting the configuration twinning processing framework in the Internet of Things; S2, defining a configuration twinning range, and setting the configuration twinning range in the Internet of Things; S3, when side end server equipment is in communication connection with a cloud server for the first time through the Internet of Things, synchronizing, by the side end server equipment, all data of the cloud server within the configuration twinning range according to the configuration twinning processing framework; and S4, enabling the side end server equipment to be in communication connection with the cloud server, and when data of the side end server equipment or the cloud server is changed, enabling the side end server equipment or the cloud server to trigger a configuration twinning section, and synchronizing the changed data to the cloud server or the side end server equipment. By using the technical scheme of the invention, the synchronous framework program is low in writing workload, short in construction period and high in system stability.