The invention discloses a protection device based on sandblast spray coating of casing installation edge spigots. The protection device based on the sandblast spray coating of the casing installationedge spigots comprises a protection mechanism and a loading and unloading mechanism, wherein the protection mechanism is composed of a fixed bottom seat, a first rotation cavity, a rotation motor, a first belt pulley, a first rotation shaft, a second belt pulley, a rotation plate, a bottom baffle, a first support pillar, a fixed installing seat, an electric telescopic rod, a second support pillar,fixed clamp grooves, a protection barrel, a clamping air cylinder, resetting clamp grooves, fixed clamp plates, a first electromagnet, a driving case, a switching motor, a driving worm, a driving worm wheel and a switching shaft. The protection device based on the sandblast spray coating of the casing installation edge spigots avoids manual clamping, is convenient and quick, saves trouble and labor, can enable a casing to rotate through the rotation motor so as to perform spray coating on the casing in work due to the fact that the rotation motor and the switching motor are arranged, improvesprocessing efficiency of the spray coating, and cannot influence normal use of a non-spraying face of the casing and achieves an adequate protection function for the casing in the sandblast spray coating process.