The invention provides a vehicle-mounted electronic tag issuing method and system based on ESAM. According to the invention, the problems of the old-fashioned issuing technology are optimized; and after a factory receives an order, assembling is not performed firstly and ESAM is sent to the issuing unit, the issuing unit directly sends the ESAM once, and after successful issuing, the ESAM is returned to the factory for assembling and packaging and is directly sent to a sales unit according to the demand of the proprietor unit. The proprietor unit issues through a new process, supports a multi-channel multi-pin issuing mode, improves the issuing efficiency, increases the issuing speed by 5-7 times, greatly reduces the labor burden, reduces the transfer link, avoids the damage of packaging,and can also be directly sold on the Internet.