Disclosed in the present invention are an anti-packet loss method, device and system for use in real-time communication, and the method comprising: sending network packets to a receiving end, the network packet including encoded video frame data and FEC redundancy data, wherein corresponding FEC redundancy levels are determined for the FEC redundancy data; receiving feedback data sent by the receiving end after the network packet is resolved and restored; when the feedback data is packet loss feedback data, according to a current packet loss model, selecting an item of FEC redundancy data having an appropriate level from among the FEC redundancy data of a plurality of preset redundancy levels, and sending the same to the receiving end; in addition, when the feedback data is decoding error feedback data, according to the current decoding error model, obtaining an independently decodable frame corresponding to a decoding error frame, and sending the same to the receiving end. The present invention solves the problems in existing technology wherein the processing of the packet loss cannot meet the demands of high quality and low bandwidth at the same time, and the anti-packet loss capability is poor. The present invention enhances anti-packet loss capability in a real-time communication.