The invention discloses a protection device for transportation and conveying of precise electronic products. The device comprises a protection box body and a protection sealing cover, the protection sealing cover is located above the protection box body, the four corners of the top of the protection box body are correspondingly provided with vertically-arranged fixing grooves, the four corners ofthe bottom of the protection sealing cover are connected with fixing pins which are vertically arranged through bolts, the bottom ends of the fixing pins are inserted into the fixing grooves, and handles are hinged to the two sides of the top of the protection sealing cover. According to the protection device, transportation and conveying workers can push the protection device to move, so that thetransportation and conveying of the precise electronic products are facilitated, the labor force is saved, meanwhile, the working efficiency is improved, first springs and second springs are used forfixing the protection box body and the protection sealing cover, first memory sponge cushion, second memory sponge cushion, buffer blocks, the first springs and the second springs can eliminate the vibration and shaking of the precise electronic products in the transportation and conveying process, so that a good protection effect is achieved, and unnecessary economic loss is avoided.