The invention relates to an electric control pneumatic gear shifting handle mechanism, which comprises a gear shifting handle, a position selecting swing arm, a gear seat, a gear shifting handle seat, a position selecting shaft, a shifting block, a gear shifting swing arm, a gear shifting shaft, a position selecting sensor, a gear shifting sensor, a gear warning device, a voice prompt system, a gear shifting swing arm strong magnet and a gear shifting swing arm seat strong magnet, wherein the position selecting sensor is fixed on one side of the gear shifting handle seat and is connected with one end of the position selecting shaft; the gear shifting sensor is fixed on one side of the gear shifting handle seat and is connected with one end of the gear shifting shaft; and the gear warning device and the voice prompt system are arranged on a gear panel. In the gear shifting handle mechanism, the gear shifting operation habit of the conventional commercial automobile mechanical transmission is not changed; superior comfort can be achieved during operation of the gear shifting handle; gear shifting operation can be easily and conveniently realized; and the mechanism has a prompt effect on the gear, and also has the advantages of compact structure, short gear shifting distance, high safety and the like.