A compound of formula I, or a pharmaceutically acceptable salt or ester thereof,wherein R1 is selected from:
aryl; heteroaryl; —NHR3; fused
aryl-C4-7-heterocycloalkyl; —CONR4R5; —NHCOR6; —C3-7-cycloalkyl; —O—C3-7-cycloalkyl; —NR3R6; and optionally substituted —C1-6
alkyl; wherein said
aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted;R2 is selected from
hydrogen, aryl, C1-6-
alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, C4-7 heterocycloalkyl and
halogen, wherein said C1-6-
alkyl, C2-6-alkenyl, aryl, heteroaryl and C4-7-heterocycloalkyl are each optionally substituted;R3 is selected from aryl, heteroaryl, C4-7-heterocycloalkyl, C3-7-cycloalkyl, fused aryl-C4-7-heterocycloalkyl and C1-6-alkyl, each of which is optionally substituted;R4 and R5 are each independently
hydrogen, or optionally substituted C3-7-cycloalkyl, aryl, heteroaryl, C1-6-alkyl or C3-6-heterocycloalkyl; or R4 and R5 together with the N to which they are attached form a C3-6-heterocycloalkyl ring;each R6 is independently selected from C1-6-alkyl, C3-7 cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substitutedeach R7 is selected from
hydrogen, optionally substituted C1-6-alkyl and C3-7-cycloalkyl;each of R8 and R9 is independently hydrogen or optionally substituted C1-6-alkyl; orR8 and R9 together with the N to which they are attached form a C4-6-heterocycloalkyl;each R10 is selected from C3-7-cycloalkyl and optionally substituted C1-6-alkyl;each R11 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C1-6 alkyl-C3-7-cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted;A is selected from
halogen, —NR4SO2R5, —CN, —OR6, —NR4R5, —NR7R11, hydroxyl, —CF3, —CONR4R5, —NR4COR5, —NR7(CO)NR4R5, —NO2, —CO2H, —CO2R6, —SO2R6, —SO2NR4R5, —NR4COR5, —NR4COOR5, C1-6-alkyl and —COR6.Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula I.