The invention discloses a frame synchronous detection method based on a zero correlation zone (ZCZ) sequence, which is used in a wireless communication system. The frame synchronous detection method comprises the following steps of: firstly, receiving the sequence, and carrying out cross-correlation operation with a local ZCZ sequence; secondly, carrying out conjugate point operation between a front symbol block and a rear symbol block on a cross-correlation operation result; and finally, carrying out a real-part maximum value of each symbol block with a threshold value, and judging whether a frame is coming or not. In order to make the maximum value more apparent, the conjugate point operation between the front symbol block and the rear symbol block on the cross-correlation operation is carried out; and if peak detection is required to be more apparent, the conjugate point operation between the front symbol block and the rear symbol block can be carried out for more times. Compared with the traditional frame detection method, the method is easy to operate and implement, and whether the frame is coming or not can be accurately judged. The method can be applicable to time synchronization, and an initial point of a signal is determined by finding the position of a negative pulse.