The invention provides a medical device and a fixing mechanism of medical equipment. The medical equipment can be conveniently located at a target position in the body through the fixing mechanism toachieve corresponding implantation or interventional treatment of the medical equipment, and accordingly, the medical effect is improved. The medical equipment can be a lead-free pacemaker, and physiological pace-making on the heart by the pacemaker is conveniently realized. The fixing mechanism comprises a base and fixing member, the extension direction of the base is parallel to that of a presetobject, and the fixing member is arranged on the outer wall of the base and extends around the base; one end of the fixing member is connected with the outer wall of the base, and a gap is formed between the other end of the fixing member and the outer wall of the base. During actual use, the base is stressed to rotate along the extension direction of the fixing member, and drives the fixing member to rotate together; during rotation, the fixing member is directly inserted into a tissue or a blood vessel wall parallel to the base, so that the medical equipment can be fixed into the atrium, the ventricle, the precava or other blood vessels, or fixed onto the interventricular septum or the interatrial septum.