78 results about "Muscle regeneration" patented technology

The invention discloses a skeletal muscle total-organ acellular matrix and derivative medical products thereof as well as a preparation method and a using method of the skeletal muscle total-organ acellular matrix and the derivative medical products thereof. The skeletal muscle total-organ acellular matrix completely preserves a three-dimensional and parallel-arrangement skeletal muscle basement membrane ultramicro structure of the skeletal muscle, a blood vessel matrix network, a muscle-muscle tendon junction, bioactive constituents such as a number of growth factors, hyaluronic acid, glycosaminoglycans, laminin and the like and high-affinity muscle-derived stem cells, and has certain mechanical strength and toughness; thorough decellularization effect is achieved, no obvious immunological rejection is caused, and no ethical and moral issues are caused, therefore, the skeletal muscle total-organ acellular matrix is a skeletal muscle regeneration bracket and platform with the most advantages reported till now. The prepared skeletal muscle total-organ acellular matrix and various derivative medical products thereof can be used for constructing and regenerating skeletal muscles in vitro and in vivo, are suitable for repairing various scoped skeletal muscle defects of all parts, and can be used for hopefully solving the large-scope skeletal muscle defect repairing and muscle generation problem which is still complicated clinically at present.

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration andmethods of increasing muscle mass are also provided herein.

An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.